AKT1S1 - AKT1 substrate 1 Gene

中文名称：AKT1 底物 1

种属: Homo sapiens

同用名: Lobe; PRAS40

基因 ID: 84335 | 基因类型: protein coding

关于 AKT1S1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,869,033-49,878,356 (from NCBI)

This gene has 9 transcripts (splice variants) and 174 orthologues. Ubiquitous expression in fat (RPKM 12.1), kidney (RPKM 8.8) and 25 other tissues.

功能概要

AKT1S1 是 Akt (MIM 164730) 的富含脯氨酸的底物，在磷酸化时结合 14-3-3 蛋白 (参见 YWHAH、MIM 113508) (Kovacina 等人，2003 [PubMed 12524439]) 。[OMIM 提供，2008 年 3 月] ]

AKT1S1 is a proline-rich substrate of Akt (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008]

AKT1S1 基因产物(5)

mRNA	Protein	Name
NM_001098632.2	NP_001092102.1	proline-rich AKT1 substrate 1 isoform b
NM_001098633.4	NP_001092103.1	proline-rich AKT1 substrate 1 isoform b
NM_001278159.2	NP_001265088.1	proline-rich AKT1 substrate 1 isoform b
NM_001278160.2	NP_001265089.1	proline-rich AKT1 substrate 1 isoform b
NM_032375.5	NP_115751.3	proline-rich AKT1 substrate 1 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	12524439	GOA
enables protein kinase inhibitor activity	IDA IDA: 通过直接分析推断	18372248	GOA
enables protein serine/threonine kinase inhibitor activity	IDA IDA: 通过直接分析推断	17386266	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of TOR signaling	IDA IDA: 通过直接分析推断	17386266	GOA
involved in negative regulation of TORC1 signaling	IDA IDA: 通过直接分析推断	17386266	GOA
involved in negative regulation of cell size	IDA IDA: 通过直接分析推断	17386266	GOA
involved in negative regulation of protein kinase activity	IDA IDA: 通过直接分析推断	17386266	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of TORC1 complex	IDA IDA: 通过直接分析推断	17386266	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

proline-rich AKT1 substrate 1

40 kDa proline-rich AKT substrate

AKT1S1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	AKT1S1	Q96B36	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	35271311
种属内	AKT1S1	Q96B36	YWHAH	Homo sapiens	Q04917	Pull Down	12524439
种属内	AKT1S1	Q96B36	YWHAZ	Homo sapiens	P63104	Pull Down	15161933

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Breast Intraductal Papillomatosis

Breast Papillomatosis

Intraductal Papillomatosis Of The Breast

Subependymal Glioma

Mixed Subependymoma-Ependymoma	Subependymal Astrocytoma
Who Grade I Ependymal Tumor	Glioma, Subependymal

Cowden Syndrome 1

Bannayan-Riley-Ruvalcaba Syndrome	Pten Hamartoma Tumor Syndrome
Lhermitte-Duclos Disease	Bannayan-Zonana Syndrome
Phts	Riley-Smith Syndrome
Bzs	Ruvalcaba-Myhre-Smith Syndrome
Multiple Hamartoma Syndrome	Rmss
Brrs	Dysplastic Gangliocytoma Of The Cerebellum
CWS1	Cs
Cd	Mham
Pten Hamartoma Tumor Syndrome With Granular Cell Tumor	Macrocephaly Multiple Lipomas And Hemangiomata
Bannayan-Ruvalcaba-Riley Syndrome	Myhre-Riley-Smith Syndrome
LDD	Cerebelloparenchymal Disorder Vi
Hamartoma Syndrome, Multiple	Bbrs
Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata	Macrocephaly, Multiple Lipomas, And Hemangiomata
Macrocephaly Pseudopapilledema And Multiple Hemangiomas	Ruvalcaba -Myhre-Smith Syndrome
Ruvalcaba-Myhre Syndrome	Cowden Disease
Macrocephaly Pseudopapilledema And Multiple Hemangiomata	Cerebellar Granule Cell Hypertrophy And Megalencephaly
Cpd6	Pten Hamartoma Tumor Syndromes
Cowden Syndrome, Type 1

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Proteus Syndrome

Proteus Syndrome, Somatic	Partial Gigantism-Nevi-Hemihypertrophy-Macrocephaly Syndrome
Gigantism, Partial, Of Hands And Feet, Nevi, Hemihypertrophy, And Macrocephaly	Wiedemann'S Syndrome
Hemihypertrophy And Macrocephaly	Partial Gigantism Of Hands And Feet, Nevi, Hemihypertrophy, Macrocephaly
Ps	PROTEUSS
Partial Gigantism Of Hands And Feet Nevi Hemihypertrophy And Macrocephaly

Cowden Syndrome

Cowden Disease	Multiple Hamartoma Syndrome
Cowden'S Disease	Lhermitte-Duclos Disease
Cd	Cs
Mham	Dysplastic Gangliocytoma Of Cerebellum
Cowden'S Syndrome	Hamartoma Syndrome, Multiple

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00545	AKT1S1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	AKT1S1	VGNC	VGNC:37771
Rattus norvegicus	AKT1S1	RGD	RGD:1312049
Mus musculus	AKT1S1	MGD	MGI:1914855
Macaca mulatta	AKT1S1	VGNC	VGNC:108461
Bos taurus	AKT1S1	VGNC	VGNC:25798

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

AKT1S1 - AKT1 substrate 1 Gene

关于 AKT1S1

功能概要

AKT1S1 基因产物(5)

AKT1S1 蛋白互作信息

关联疾病

直系同源

热门区域

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AKT1S1 - AKT1 substrate 1 Gene

关于 AKT1S1

功能概要

AKT1S1 基因产物(5)

AKT1S1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z