ARHGEF16 - Rho guanine nucleotide exchange factor 16 Gene

中文名称：Rho 鸟嘌呤核苷酸交换因子 16

种属: Homo sapiens

同用名: NBR; GEF16

基因 ID: 27237 | 基因类型: protein coding

关于 ARHGEF16

Cytogenetic location: 1p36.32 Genomic coordinates (GRCh38): 1:3,454,665-3,481,113 (from NCBI)

This gene has 7 transcripts (splice variants), 193 orthologues and 6 paralogues. Broad expression in duodenum (RPKM 15.0), small intestine (RPKM 12.9) and 17 other tissues.

功能概要

虽然这种蛋白质的具体功能尚不清楚，但它被认为参与了蛋白质-蛋白质和蛋白质-脂质相互作用。[RefSeq 提供，2008 年 7 月]

Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions. [provided by RefSeq, Jul 2008]

ARHGEF16 基因产物(1)

mRNA	Protein	Name
NM_014448.4	NP_055263.2	rho guanine nucleotide exchange factor 16

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables PDZ domain binding	IPI IPI: 通过物理相互作用推断	21139582	GOA
enables guanyl-nucleotide exchange factor activity	IDA IDA: 通过直接分析推断	20679435	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15161933	GOA
enables receptor tyrosine kinase binding	IPI IPI: 通过物理相互作用推断	20679435	GOA
enables small GTPase binding	IPI IPI: 通过物理相互作用推断	20679435	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in activation of GTPase activity	IDA IDA: 通过直接分析推断	21139582	GOA
involved in activation of GTPase activity	IMP IMP: 通过突变表型推断	20679435	GOA
involved in cell chemotaxis	IMP IMP: 通过突变表型推断	20679435	GOA
involved in positive regulation of protein localization to plasma membrane	IMP IMP: 通过突变表型推断	20679435	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARHGEF16 蛋白结构

RhoGEF

SH3_9

0
200
400
600
709 a.a.

蛋白主名

其他名称

rho guanine nucleotide exchange factor 16

Rho guanine exchange factor (GEF) 16

ARHGEF16 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ARHGEF16	Q5VV41	BOLL	Homo sapiens	Q8N9W6-4	Y2H Prey Pooling	32296183
种属内	ARHGEF16	Q5VV41	BOLL	Homo sapiens	Q8N9W6-4	Validated Y2H	32296183
种属内	ARHGEF16	Q5VV41	BOLL	Homo sapiens	Q8N9W6-4	Y2H Array	32296183
种属内	ARHGEF16	Q5VV41	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	33961781
种属内	ARHGEF16	Q5VV41	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
种属内	ARHGEF16	Q5VV41	HNRNPH1	Homo sapiens	P31943	Y2H Array	32296183
种属内	ARHGEF16	Q5VV41	HNRNPH1	Homo sapiens	P31943	Y2H Prey Pooling	32296183
种属内	ARHGEF16	Q5VV41	YWHAE	Homo sapiens	P62258	Crosslink	36931259
种属内	ARHGEF16	Q5VV41	TFG	Homo sapiens	Q92734	Y2H Array	25416956
种属内	ARHGEF16	Q5VV41	TFG	Homo sapiens	Q92734	Validated Y2H	25416956
种属内	ARHGEF16	Q5VV41	SCRIB	Homo sapiens	Q14160	Anti Tag CoIP	32203420
种属内	ARHGEF16	Q5VV41	DLG1	Homo sapiens	Q12959	Anti Tag CoIP	32203420
种属内	ARHGEF16	Q5VV41	MAGED1	Homo sapiens	Q9Y5V3	Y2H Prey Pooling	32296183
种属内	ARHGEF16	Q5VV41	MAGED1	Homo sapiens	Q9Y5V3	Validated Y2H	32296183
种属内	ARHGEF16	Q5VV41	MAGED1	Homo sapiens	Q9Y5V3	Y2H Array	32296183
种属内	ARHGEF16	Q5VV41	MAPK1IP1L	Homo sapiens	Q8NDC0	Validated Y2H	25416956
种属内	ARHGEF16	Q5VV41	LASP1	Homo sapiens	Q14847-2	Y2H Prey Pooling	32296183
种属内	ARHGEF16	Q5VV41	LASP1	Homo sapiens	Q14847-2	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Epilepsy, Idiopathic Generalized 2

EIG2	Epilepsy, Idiopathic Generalized, Susceptibility To, 2
Idiopathic Generalized Epilepsy 2	Epilepsy, Idiopathic Generalized Locus On Chromosome 14
Epilepsy, Idiopathic Generalized, Susceptibility To, Locus On Chromosome 14

Frontal Sinusitis

Facial Neuralgia

Gastrojejunal Ulcer

Acute Gastrojejunal Ulcer With Hemorrhage	Acute Gastrojejunal Ulcer With Hemorrhage And Obstruction
Acute Gastrojejunal Ulcer With Hemorrhage And Perforation	Acute Gastrojejunal Ulcer With Hemorrhage And Perforation, With Obstruction
Acute Gastrojejunal Ulcer With Hemorrhage, With Perforation And With Obstruction	Acute Gastrojejunal Ulcer With Perforation
Acute Gastrojejunal Ulcer With Perforation And Obstruction	Acute Gastrojejunal Ulcer With Perforation, With Obstruction
Acute Gastrojejunal Ulcer Without Hemorrhage And Without Perforation	Acute Gastrojejunal Ulcer Without Hemorrhage, Without Perforation And Without Obstruction
Acute Gastrojejunal Ulcer Without Mention Of Hemorrhage Or Perforation, Without Mention Of Obstruction	Acute Gastrojejunal Ulcer, With Hemorrhage, With Obstruction
Chronic Gastrojejunal Ulcer Without Hemorrhage And Without Perforation	Chronic Gastrojejunal Ulcer Without Hemorrhage, Without Perforation And Without Obstruction
Chronic Gastrojejunal Ulcer Without Mention Of Hemorrhage Or Perforation, Without Mention Of Obstruction	Marginal Ulcer

Locked-In Syndrome

Locked In Syndrome	Cerebromedullospinal Disconnection
Locked-In State	Quadriplegia

Osteogenesis Imperfecta, Type I

Osteogenesis Imperfecta Type I	OI1
Oi, Type I	Osteogenesis Imperfecta Tarda
Osteogenesis Imperfecta With Blue Sclerae	Osteogenesis Imperfecta Type 1
Adair-Dighton Syndrome	Mild Osteogenesis Imperfecta
Non-Deforming Osteogenesis Imperfecta	Oi Type 1
Van Der Hoeve Syndrome	Classic Non-Deforming Oi With Blue Sclerae
Osteogenesis Imperfecta 1	Oi-I
Osteopenic Non-Fracture Syndrome	Osteogenesis Imperfecta, Mild
Osteogenesis Imperfecta	Lobstein'S Disease

Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome	Deletion 1p36
Monosomy 1p36	Subtelomeric 1p36 Deletion
Monosomy 1p36 Syndrome	Distal Monosomy 1p36
Del(1)(P36)	Deletion 1pter
Monosomy 1pter

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00951	ARHGEF16 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	ARHGEF16	RGD	RGD:1588981
Mus musculus	ARHGEF16	MGD	MGI:2446219
Bos taurus	ARHGEF16	VGNC	VGNC:26108
Felis catus	ARHGEF16	VGNC	VGNC:59901
Canis familiaris	ARHGEF16	VGNC	VGNC:38077
Macaca mulatta	ARHGEF16	VGNC	VGNC:69830

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