PFKFB2 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Gene

中文名称：6-磷酸果糖-2-激酶/果糖-2,6-双磷酸酶 2

种属: Homo sapiens

同用名: PFK-2/FBPase-2

关于 PFKFB2

功能概要

该基因编码的蛋白质参与果糖-2,6-二磷酸的合成和降解，果糖是一种控制真核生物糖酵解的调节分子。编码的蛋白质具有催化 2,6-二磷酸果糖合成的 6-磷酸果糖-2-激酶活性和催化 2,6-二磷酸果糖降解的 2,6-二磷酸果糖酶活性。这种蛋白质调节心脏中的果糖 2,6-二磷酸水平，而由不同基因编码的相关酶调节肝脏和肌肉中的果糖 2,6-二磷酸水平。这种酶作为同型二聚体发挥作用。已发现该基因的两个转录变体编码两种不同的亚型。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related Enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This Enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]