2. Gene
  3. Bad - BCL2-associated agonist of cell death Gene

Bad - BCL2-associated agonist of cell death Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Bbc2

基因 ID: 12015 | 基因类型: protein coding

关于 Bad

功能概要

Enables cysteine-type endopeptidase activator activity involved in apoptotic process and protein Phosphatase binding activity. Involved in several processes, including positive regulation of cell communication; positive regulation of Glucokinase activity; and positive regulation of mitochondrial membrane potential. Acts upstream of or within several processes, including apoptotic signaling pathway; modulation by virus of host apoptotic process; and positive regulation of lymphocyte differentiation. Located in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in endometrial cancer; lung non-small cell carcinoma; and pancreatic Cancer. Orthologous to human BAD (BCL2 associated agonist of cell death). [provided by Alliance of Genome Resources, Apr 2022]

Bad 基因产物(2)

mRNA Protein Name
NM_001285453.1 NP_001272382.1 bcl2-associated agonist of cell death isoform 2
NM_007522.3 NP_031548.1 bcl2-associated agonist of cell death isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type endopeptidase activator activity involved in apoptotic process IDA
IDA: 通过直接分析推断
19915011 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
7834748 MGI
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
12944463 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ADP metabolic process IMP
IMP: 通过突变表型推断
18223655 MGI
involved in ATP metabolic process IMP
IMP: 通过突变表型推断
18223655 MGI
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
19915011 MGI
acts upstream of or within apoptotic signaling pathway IDA
IDA: 通过直接分析推断
11717309 MGI
acts upstream of or within apoptotic signaling pathway IMP
IMP: 通过突变表型推断
12931191 MGI
involved in cellular response to lipid IEP
IEP: 通过表达模式推断
18223655 MGI
acts upstream of or within cytokine-mediated signaling pathway IDA
IDA: 通过直接分析推断
14967141 MGI
acts upstream of or within epithelial cell proliferation IDA
IDA: 通过直接分析推断
9176392 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IDA
IDA: 通过直接分析推断
12115603 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IGI
IGI: 通过遗传相互作用推断
12431371 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: 通过突变表型推断
14967141 MGI
acts upstream of or within extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: 通过突变表型推断
12431371 MGI
acts upstream of or within glucose catabolic process IMP
IMP: 通过突变表型推断
12931191 MGI
acts upstream of or within glucose homeostasis IMP
IMP: 通过突变表型推断
12931191 MGI
involved in glucose homeostasis IMP
IMP: 通过突变表型推断
18223655 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IDA
IDA: 通过直接分析推断
15231831 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: 通过突变表型推断
12431371 MGI
acts upstream of or within positive regulation of B cell differentiation IMP
IMP: 通过突变表型推断
12431371 MGI
acts upstream of or within positive regulation of T cell differentiation IMP
IMP: 通过突变表型推断
12431371 MGI
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
21095239 MGI
involved in positive regulation of insulin secretion IMP
IMP: 通过突变表型推断
18223655 MGI
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
18223655 MGI
involved in positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress IDA
IDA: 通过直接分析推断
21716255 MGI
involved in positive regulation of mitochondrial membrane potential IMP
IMP: 通过突变表型推断
18223655 MGI
involved in positive regulation of type B pancreatic cell development IMP
IMP: 通过突变表型推断
18223655 MGI
acts upstream of or within regulation of apoptotic process IDA
IDA: 通过直接分析推断
7834748 MGI
acts upstream of or within regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
14967141 MGI
acts upstream of or within release of cytochrome c from mitochondria IMP
IMP: 通过突变表型推断
12431371 MGI
acts upstream of or within symbiont-mediated activation of host apoptosis IDA
IDA: 通过直接分析推断
15231831 MGI
acts upstream of or within symbiont-mediated suppression of host apoptosis IDA
IDA: 通过直接分析推断
15231831 MGI
acts upstream of or within symbiont-mediated suppression of host apoptosis IMP
IMP: 通过突变表型推断
15231831 MGI
involved in type B pancreatic cell proliferation IMP
IMP: 通过突变表型推断
18223655 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11146504 MGI
located in cytosol IDA
IDA: 通过直接分析推断
11980919 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
12931191 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

bcl2-associated agonist of cell death

bcl-2-binding component 6

bcl-xL/Bcl-2-associated death promoter

bcl2 antagonist of cell death

Bad 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Bad Q61337 BCL2L1 Homo sapiens Q07817-1
Anti Tag CoIP
15694340
种属间
Bad Q61337 YWHAZ Homo sapiens P63104
Pull Down
11723239
种属内
Bad Q61337 Bcl2l1 Mus musculus Q64373-1
Anti Bait CoIP
23332762
种属间
Bad Q61337 BCL2 Homo sapiens P10415
Anti Tag CoIP
15694340
种属间
Bad Q61337 BCL2 Homo sapiens P10415
FPS
16697956
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-14266 Dapivirine 99.80% Phase 3
HY-119368 NPB Inhibitor ≥98.0% Phase 3
HY-50868 Bafetinib 99.77% Phase 2
Pre-clinical Phase
生物活性分子 (17)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-18095 CX-6258 Inhibitor 98.71% 否
HY-18095A CX-6258 hydrochloride hydrate Inhibitor 99.23% 否
HY-111552 PIM1-IN-1 Inhibitor 99.83% 否
HY-18095B CX-6258 hydrochloride Inhibitor 99.03% 否
HY-P2468 BAD (103-127) (human) Inhibitor 98.80% 否
HY-14266S Dapivirine-d11 / 否
HY-P2499 BAD (103-127) (human), FAM-labeled Inhibitor / 否
HY-120035 DD1 99.40% 否
HY-14266A Dapivirine hydrochloride / 否
HY-145844 EGFR-IN-44 / 否
HY-146395 HBV-IN-23 / 否
HY-147342 β-Benzamide adenine dinucleotide Inhibitor / 否
HY-15901 LGB321 Inhibitor / 否
HY-15901A LGB321 monohydrochloride Inhibitor / 否
HY-168338 CB2 receptor agonist 8 / 否
HY-P5324 Bad BH3 (mouse) / 否
HY-RS01341 BAD Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bad NCBI NCBI:572
Macaca fascicularis Bad NCBI NCBI:102121921
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