2. Gene
  3. ARHGAP21 - Rho GTPase activating protein 21 Gene

ARHGAP21 - Rho GTPase activating protein 21 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Rho GTP 酶激活蛋白 21

种属: Homo sapiens

同用名: ARHGAP10

基因 ID: 57584 | 基因类型: protein coding

关于 ARHGAP21

Cytogenetic location: 10p12.1 Genomic coordinates (GRCh38): 10:24,583,614-24,723,887 (from NCBI)

This gene has 19 transcripts (splice variants), 274 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 26.0), fat (RPKM 12.0) and 25 other tissues.

功能概要

ARHGAP21 优先作为 CDC42 (MIM 116952) 的 GTP 酶激活蛋白 (GAP) 发挥作用，并通过控制 CDC42 活性来调节高尔基体的 ARP2/3 复合物 (MIM 604221) 和 F-肌动蛋白动力学 (Dubois 等人，2005 [ PubMed 15793564]) .[OMIM 提供，2008 年 3 月]

ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]

ARHGAP21 基因产物(10)

mRNA Protein Name
NM_001367447.1 NP_001354376.1 rho GTPase-activating protein 21 isoform b
NM_001367448.1 NP_001354377.1 rho GTPase-activating protein 21 isoform a
NM_001367449.1 NP_001354378.1 rho GTPase-activating protein 21 isoform c
NM_001367450.1 NP_001354379.1 rho GTPase-activating protein 21 isoform c
NM_001367451.1 NP_001354380.1 rho GTPase-activating protein 21 isoform b
NM_001367452.1 NP_001354381.1 rho GTPase-activating protein 21 isoform d
NM_001367453.1 NP_001354382.1 rho GTPase-activating protein 21 isoform b
NM_001367454.1 NP_001354383.1 rho GTPase-activating protein 21 isoform a
NM_001367455.1 NP_001354384.1 rho GTPase-activating protein 21 isoform e
NM_020824.4 NP_065875.3 rho GTPase-activating protein 21 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15161933 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Golgi organization IMP
IMP: 通过突变表型推断
20525016 GOA
involved in establishment of Golgi localization IDA
IDA: 通过直接分析推断
20525016 GOA
involved in maintenance of Golgi location IMP
IMP: 通过突变表型推断
20525016 GOA
involved in organelle transport along microtubule IMP
IMP: 通过突变表型推断
20525016 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
20525016 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARHGAP21 蛋白结构

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (93 - 155)

PH

PH: PH domain (933 - 1038)

RhoGAP

RhoGAP: RhoGAP domain (1162 - 1312)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 1958 a.a.
蛋白主名 其他名称

rho GTPase-activating protein 21

Rho-GTPase activating protein 10

关联疾病

疾病名称 别名
Aarskog-Scott Syndrome

Aarskog Syndrome

Faciogenital Dysplasia

Faciodigitogenital Syndrome

AAS

Fgdy

X-Linked Aarskog Syndrome

Intellectual Developmental Disorder, X-Linked, Syndromic 16

Aarskog Syndrome, X-Linked

Intellectual Developmental Disorder, X-Linked Syndromic 16

Greig'S Syndrome

Aarskog Scott Syndrome

Aarskog Disease

Scott Aarskog Syndrome

Facio-Digito-Genital Dysplasia

Faciogenital Dysplasia With Attention Deficit-Hyperactivity Disorder

Aarskog-Scott Syndrome ) Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00921 ARHGAP21 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ARHGAP21 RGD RGD:1311028
Canis familiaris ARHGAP21 VGNC VGNC:38051
Felis catus ARHGAP21 VGNC VGNC:59879
Bos taurus ARHGAP21 VGNC VGNC:26080
Macaca mulatta ARHGAP21 VGNC VGNC:100296
Mus musculus ARHGAP21 MGD MGI:1918685
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z