2. Gene
  3. EEF1D - eukaryotic translation elongation factor 1 delta Gene

EEF1D - eukaryotic translation elongation factor 1 delta Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：真核翻译延伸因子 1 delta

种属: Homo sapiens

同用名: EF1D; EF-1D; FP1047

基因 ID: 1936 | 基因类型: protein coding

关于 EEF1D

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,579,728-143,597,415 (from NCBI)

This gene has 54 transcripts (splice variants), 1 gene allele, 266 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 42.9), spleen (RPKM 28.8) and 25 other tissues.

功能概要

该基因编码延伸因子 1 复合物的一个亚基，负责将氨酰 tRNA 酶促递送至核糖体。该亚基 delta 起鸟嘌呤核苷酸交换因子的作用。据报道，在 HIV-1 感染后，该亚基与 HIV-1 Tat 相互作用。这种相互作用导致宿主细胞蛋白翻译的抑制和病毒蛋白翻译的增强。已经为该基因发现了几种编码多种同种型的可变剪接转录物变体。相关假基因已在 1、6、7、9、11、13、17、19 号染色体上定义。[RefSeq 提供，2010 年 8 月]

This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 Infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of Viral Proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010]

EEF1D 基因产物(10)

mRNA Protein Name
NM_001130053.5 NP_001123525.3 elongation factor 1-delta isoform 1
NM_001130055.4 NP_001123527.1 elongation factor 1-delta isoform 2
NM_001130056.5 NP_001123528.1 elongation factor 1-delta isoform 4
NM_001130057.4 NP_001123529.1 elongation factor 1-delta isoform 2
NM_001195203.4 NP_001182132.1 elongation factor 1-delta isoform 5
NM_001289950.4 NP_001276879.1 elongation factor 1-delta isoform 2
NM_001317743.4 NP_001304672.1 elongation factor 1-delta isoform 4
NM_001330646.3 NP_001317575.1 elongation factor 1-delta isoform 4
NM_001960.7 NP_001951.2 elongation factor 1-delta isoform 2
NM_032378.7 NP_115754.4 elongation factor 1-delta isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
21597468 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
21597468 GOA
enables heat shock protein binding IPI
IPI: 通过物理相互作用推断
21597468 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16169070 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to heat IMP
IMP: 通过突变表型推断
21597468 GOA
involved in cellular response to ionizing radiation IDA
IDA: 通过直接分析推断
8168075 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
21597468 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
8743958 GOA
colocalizes with endoplasmic reticulum IDA
IDA: 通过直接分析推断
8743958 GOA
NOT located in nucleus IDA
IDA: 通过直接分析推断
21597468 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21597468 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EEF1D 蛋白结构

EF-1_beta_acid

EF-1_beta_acid: Eukaryotic elongation factor 1 beta central acidic region (159 - 186)

EF1_GNE

EF1_GNE: EF-1 guanine nucleotide exchange domain (195 - 281)

  • 0
  • 100
  • 200
  • 281 a.a.
蛋白主名 其他名称

elongation factor 1-delta

EF-1-delta

EEF1D 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
EEF1D P29692 EEF1G Homo sapiens P26641-2
Validated Y2H
25416956
种属内
EEF1D P29692 CAMSAP2 Homo sapiens Q08AD1
Display Tech
20195357
种属内
EEF1D P29692 ARHGAP21 Homo sapiens Q5T5U3
Display Tech
20195357
种属内
EEF1D P29692 TPT1 Homo sapiens P13693
Validated Y2H
25416956
种属内
EEF1D P29692 EEF1G Homo sapiens P26641
Y2H Pooling
16189514
种属内
EEF1D P29692 EEF1G Homo sapiens P26641
Y2H Pooling
16169070
种属内
EEF1D P29692 EEF1G Homo sapiens P26641
Anti Tag CoIP
33961781
种属内
EEF1D P29692 HTT Homo sapiens P42858
Validated Y2H
32814053
种属内
EEF1D P29692 HTT Homo sapiens P42858
Y2H Pooling
32814053
种属内
EEF1D P29692 HTT Homo sapiens P42858
Y2H Array
32814053
种属内
EEF1D P29692 ABTB1 Homo sapiens Q969K4
Y2H Array
31515488
种属内
EEF1D P29692 ABTB1 Homo sapiens Q969K4
Anti Tag CoIP
33961781
种属内
EEF1D P29692 MAX Homo sapiens P61244
Pull Down
25609649
种属内
EEF1D P29692 ERP27 Homo sapiens Q96DN0
Y2H Array
25416956
种属内
EEF1D P29692 ERP27 Homo sapiens Q96DN0
Y2H Prey Pooling
25416956
种属内
EEF1D P29692 ERP27 Homo sapiens Q96DN0
Y2H Array
31515488
种属内
EEF1D P29692 ERP27 Homo sapiens Q96DN0
Validated Y2H
25416956
种属内
EEF1D P29692 SOD1 Homo sapiens P00441
Display Tech
20195357
种属间
EEF1D P29692 PA Influenza A virus Q67020
Pull Down
21994455
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive

Autosomal Recessive Mental Retardation

Autosomal Recessive Non-Syndromic Mental Retardation

Autosomal Recessive Non-Syndromic Intellectual Disability
Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04177 EEF1D Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus EEF1D VGNC VGNC:81649
Bos taurus EEF1D VGNC VGNC:53861
Rattus norvegicus EEF1D RGD RGD:621174
Canis familiaris EEF1D VGNC VGNC:40208
Mus musculus EEF1D MGD MGI:1913906
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z