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  2. CDC25C - cell division cycle 25C Gene

CDC25C - cell division cycle 25C Gene

中文名称:细胞分裂周期 25C

种属: Homo sapiens

同用名: CDC25; PPP1R60

基因 ID: 995 | 基因类型: protein coding

关于 CDC25C

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:138,285,265-138,338,355 (from NCBI)

This gene has 9 transcripts (splice variants), 122 orthologues and 2 paralogues. Biased expression in testis (RPKM 7.7), bone marrow (RPKM 1.3) and 8 other tissues.

功能概要

该基因编码一种在细胞分裂调控中起关键作用的保守蛋白。编码的蛋白质指导细胞周期蛋白 B 结合的 CDC2 去磷酸化并触发进入有丝分裂。它还抑制 p53 诱导的生长停滞。已经描述了该基因的多个选择性剪接的转录物变体。[RefSeq 提供,2015 年 12 月]

This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015]

CDC25C 基因产物(8)

mRNA Protein Name
NM_001287582.2 NP_001274511.1 M-phase inducer phosphatase 3 isoform a
NM_001287583.2 NP_001274512.1 M-phase inducer phosphatase 3 isoform c
NM_001318098.2 NP_001305027.1 M-phase inducer phosphatase 3 isoform e
NM_001364026.1 NP_001350955.1 M-phase inducer phosphatase 3 isoform f
NM_001364027.1 NP_001350956.1 M-phase inducer phosphatase 3 isoform g
NM_001364028.1 NP_001350957.1 M-phase inducer phosphatase 3 isoform h
NM_001790.5 NP_001781.2 M-phase inducer phosphatase 3 isoform a
NM_022809.4 NP_073720.1 M-phase inducer phosphatase 3 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables WW domain binding IPI
IPI: 通过物理相互作用推断
10037602 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9543386 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
9543386 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G2/M transition of mitotic cell cycle IGI
IGI: 通过遗传相互作用推断
2195549 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
14968113 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CDC25C 蛋白结构

M-inducer_phosp

M-inducer_phosp: M-phase inducer phosphatase (93 - 155)

M-inducer_phosp

M-inducer_phosp: M-phase inducer phosphatase (155 - 272)

Rhodanese

Rhodanese: Rhodanese-like domain (320 - 419)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 473 a.a.
蛋白主名 其他名称

M-phase inducer phosphatase 3

CDC25 homolog C

CDC25C 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CDC25C P30307 LZTS1 Homo sapiens Q9Y250
Anti Tag CoIP
17349584
种属内
CDC25C P30307 YWHAZ Homo sapiens P63104
Anti Tag CoIP
27880917
种属内
CDC25C P30307 YWHAZ Homo sapiens P63104
Pull Down
15161933
种属内
CDC25C P30307 YWHAE Homo sapiens P62258
Crosslink
36931259
种属内
CDC25C P30307 YWHAE Homo sapiens P62258
Anti Tag CoIP
27880917
种属内
CDC25C P30307 YWHAB Homo sapiens P31946
Pull Down
28330616
种属内
CDC25C P30307 YWHAB Homo sapiens P31946
Anti Bait CoIP
19470455
种属内
CDC25C P30307 YWHAB Homo sapiens P31946
Anti Tag CoIP
27880917
种属内
CDC25C P30307 CDK1 Homo sapiens P06493
Anti Tag CoIP
17349584
种属内
CDC25C P30307 CDK1 Homo sapiens P06493
Anti Tag CoIP
27880917
种属内
CDC25C P30307 PLK1 Homo sapiens P53350
Pull Down
12595692
种属内
CDC25C P30307 CHEK1 Homo sapiens O14757
Protein Kinase Assay
16330544
种属内
CDC25C P30307 CHEK1 Homo sapiens O14757
Protein Kinase Assay
11836499
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ataxia-Telangiectasia

Ataxia Telangiectasia

Louis-Bar Syndrome

AT

At1

Ataxia-Telangiectasia Syndrome

Ataxia - Telangiectasia Variant

Boder-Sedgwick Syndrome

Louis Bar Syndrome

Cerebello-Oculocutaneous Telangiectasia

Immunodeficiency With Ataxia Telangiectasia

A-T

Ataxia Telangiectasia Syndrome

Atm

Telangiectasia, Cerebello-Oculocutaneous

Ataxia-Telangiectasia Variant

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus CDC25C VGNC VGNC:60651
Rattus norvegicus CDC25C RGD RGD:1311875
Mus musculus CDC25C MGD MGI:88350
Macaca mulatta CDC25C VGNC VGNC:70796
Canis familiaris CDC25C VGNC VGNC:38991
Bos taurus CDC25C VGNC VGNC:27064