2. Gene
  3. SIK3 - SIK family kinase 3 Gene

SIK3 - SIK family kinase 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SIK 家族激酶 3

种属: Homo sapiens

同用名: L19; QSK; SEMDK; SIK-3

基因 ID: 23387 | 基因类型: protein coding

关于 SIK3

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:116,843,402-117,098,428 (from NCBI)

This gene has 13 transcripts (splice variants), 224 orthologues, 17 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 19.2), brain (RPKM 13.9) and 25 other tissues.

功能概要

启用 ATP 绑定活动；镁离子结合活性；和蛋白丝氨酸/苏氨酸激酶活性。参与 TORC1 信号的正调控； TORC2 信号的正调控；和蛋白质磷酸化。位于核质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of TORC1 signaling; positive regulation of TORC2 signaling; and protein phosphorylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SIK3 基因产物(22)

mRNA Protein Name
XM_047426671.1 XP_047282627.1 serine/threonine-protein kinase SIK3 isoform X1
NM_001366687.1 NP_001353616.1 serine/threonine-protein kinase SIK3 isoform 5
XM_047426676.1 XP_047282632.1 serine/threonine-protein kinase SIK3 isoform X13
XM_011542723.3 XP_011541025.1 serine/threonine-protein kinase SIK3 isoform X7
XM_005271484.4 XP_005271541.2 serine/threonine-protein kinase SIK3 isoform X5
XM_005271482.5 XP_005271539.2 serine/threonine-protein kinase SIK3 isoform X2
XM_005271485.4 XP_005271542.1 serine/threonine-protein kinase SIK3 isoform X8
NM_001281749.3 NP_001268678.1 serine/threonine-protein kinase SIK3 isoform 3
XM_017017425.2 XP_016872914.1 serine/threonine-protein kinase SIK3 isoform X7
XM_017017426.2 XP_016872915.1 serine/threonine-protein kinase SIK3 isoform X7
NM_025164.6 NP_079440.3 serine/threonine-protein kinase SIK3 isoform 1
XM_047426673.1 XP_047282629.1 serine/threonine-protein kinase SIK3 isoform X9
NM_001366686.3 NP_001353615.1 serine/threonine-protein kinase SIK3 isoform 4
XM_011542724.3 XP_011541026.1 serine/threonine-protein kinase SIK3 isoform X7
XM_047426675.1 XP_047282631.1 serine/threonine-protein kinase SIK3 isoform X12
XM_017017424.2 XP_016872913.1 serine/threonine-protein kinase SIK3 isoform X6
XM_011542725.3 XP_011541027.1 serine/threonine-protein kinase SIK3 isoform X7
NM_001281748.3 NP_001268677.1 serine/threonine-protein kinase SIK3 isoform 2
XM_047426674.1 XP_047282630.1 serine/threonine-protein kinase SIK3 isoform X11
XM_011542722.2 XP_011541024.1 serine/threonine-protein kinase SIK3 isoform X3
XM_047426672.1 XP_047282628.1 serine/threonine-protein kinase SIK3 isoform X4
XM_011542726.2 XP_011541028.1 serine/threonine-protein kinase SIK3 isoform X10
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
14976552 GOA
enables magnesium ion binding IDA
IDA: 通过直接分析推断
14976552 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16306228 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
14976552 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of TORC1 signaling IMP
IMP: 通过突变表型推断
30232230 GOA
involved in positive regulation of TORC2 signaling IMP
IMP: 通过突变表型推断
30232230 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
14976552 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SIK3 蛋白结构

Pkinase

Pkinase: Protein kinase domain (8 - 259)

  • 0
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  • 1000
  • 1263 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase SIK3

salt-inducible kinase 3

serine/threonine-protein kinase QSK

SIK3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SIK3 Q9Y2K2 YWHAZ Homo sapiens P63104
TAP
16306228
种属内
SIK3 Q9Y2K2 YWHAZ Homo sapiens P63104
Pull Down
16306228
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Advanced Sleep Phase Syndrome

Fasps

Familial Advanced Sleep-Phase Syndrome

Advanced Sleep Phase Syndrome, Familial

Familial Advanced Sleep Phase Syndrome

Sleep Phase Syndrome, Advanced, Familial

Advanced Sleep-Phase Syndrome, Familial
Metaphyseal Chondrodysplasia, Jansen Type

Metaphyseal Chondrodysplasia, Murk Jansen Type

MCDJ

Jansen'S Metaphyseal Chondrodysplasia

Murk Jansen Type Metaphyseal Chondrodysplasia

Jansen Type Metaphyseal Chondrodysplasia

Jansen Disease

Jansen Metaphyseal Chondrodysplasia

Jansen Metaphyseal Dysostosis

Metaphyseal Chondrodysplasia Murk Jansen Type

Chondrodysplasia, Metaphyseal, Murk Jansen Type
Spondyloepimetaphyseal Dysplasia

Dysplasia, Spondyloepimetaphyseal
Spondyloepimetaphyseal Dysplasia, Krakow Type

SEMDK

Immunoosseous Dysplasia, Krakow Type
Achromatopsia 3

ACHM3

Pingelapese Blindness

Total Colorblindness With Myopia

Achromatopsia With Myopia

Achm1

Rmch1

Rod Monochromacy 1

Rod Monochromatism 1

Achm1, Formerly

Rod Monochromatism 1, Formerly

Rod Monochromacy 1, Formerly

Rmch1, Formerly

Achromatopsia-3

Achromatopsia, Type 3
Mesomelia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15776 HG-9-91-01 Inhibitor 99.77% 否
HY-101147 YKL-05-099 Inhibitor 99.76% 否
HY-120877 MRT199665 Inhibitor 99.74% 否
HY-120856 ARN-3236 Inhibitor 98.60% 否
HY-157442 GLPG3312 Inhibitor 98.25% 否
HY-N1570 Pterosin B Inhibitor 99.92% 否
HY-148061 DB1113 99.28% 否
HY-139253 MRIA9 Inhibitor 98.80% 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SIK3 VGNC VGNC:65144
Bos taurus SIK3 VGNC VGNC:34620
Rattus norvegicus SIK3 RGD RGD:1593938
Macaca mulatta SIK3 VGNC VGNC:77330
Mus musculus SIK3 MGD MGI:2446296
Canis familiaris SIK3 VGNC VGNC:46171
Others SIK3 NCBI
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