1. Gene
  2. RND3 - Rho family GTPase 3 Gene

RND3 - Rho family GTPase 3 Gene

中文名称:Rho 家族 GTPase 3

种属: Homo sapiens

同用名: ARHE; Rho8; RhoE; memB

基因 ID: 390 | 基因类型: protein coding

关于 RND3

Cytogenetic location: 2q23.3 Genomic coordinates (GRCh38): 2:150,468,193-150,487,695 (from NCBI)

This gene has 9 transcripts (splice variants), 264 orthologues and 22 paralogues. Broad expression in esophagus (RPKM 87.1), liver (RPKM 49.1) and 19 other tissues.

功能概要

该基因编码的蛋白质是小 GTPase 蛋白质超家族的成员。编码的蛋白质仅结合 GTP 但没有 GTP 酶活性,并且似乎充当细胞骨架组织的负调节剂,导致粘附力丧失。已经鉴定出编码相同蛋白质的多个可变剪接变体。[RefSeq 提供,2011 年 12 月]

This gene encodes a protein which is a member of the small GTPase protein superfamily. The encoded protein binds only GTP but has no GTPase activity, and appears to act as a negative regulator of cytoskeletal organization leading to loss of adhesion. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

RND3 基因产物(2)

mRNA Protein Name
NM_001254738.1 NP_001241667.1 rho-related GTP-binding protein RhoE precursor
NM_005168.5 NP_005159.1 rho-related GTP-binding protein RhoE precursor

RND3 蛋白结构

Ras

Ras: Ras family (25 - 193)

  • 0
  • 100
  • 200
  • 244 a.a.
蛋白主名 其他名称

rho-related GTP-binding protein RhoE

protein MemB

RND3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RND3 P61587 PLXNB1 Homo sapiens O43157
ITC
29040270
种属内
RND3 P61587 PLXNB1 Homo sapiens O43157
GMS
29040270
种属内
RND3 P61587 YWHAZ Homo sapiens P63104
ITC
23622247
种属内
RND3 P61587 YWHAZ Homo sapiens P63104
Pull Down
23622247
种属内
RND3 P61587 YWHAZ Homo sapiens P63104
SPR
23622247
种属内
RND3 P61587 YWHAB Homo sapiens P31946
Pull Down
23622247
种属内
RND3 P61587 YWHAB Homo sapiens P31946
Anti Tag CoIP
33961781
种属内
RND3 P61587 PLXNB2 Homo sapiens O15031
ITC
29040270
种属内
RND3 P61587 PLXNB2 Homo sapiens O15031
GMS
29040270
种属内
RND3 P61587 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
种属内
RND3 P61587 CPLANE2 Homo sapiens Q9BU20
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma

Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive

Hydrocephalus, X-Linked

Hydrocephalus Adverse Event

Hydrocephaly Nos

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris RND3 VGNC VGNC:45618
Rattus norvegicus RND3 RGD RGD:1359690
Mus musculus RND3 MGD MGI:1921444
Macaca mulatta RND3 VGNC VGNC:76883
Felis catus RND3 VGNC VGNC:68099
Bos taurus RND3 VGNC VGNC:34006