2. Gene
  3. PCM1 - pericentriolar material 1 Gene

PCM1 - pericentriolar material 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：周围物质 1

种属: Homo sapiens

同用名: PTC4; RET/PCM-1

基因 ID: 5108 | 基因类型: protein coding

关于 PCM1

Cytogenetic location: 8p22 Genomic coordinates (GRCh38): 8:17,922,988-18,029,948 (from NCBI)

This gene has 22 transcripts (splice variants), 212 orthologues and is associated with 93 phenotypes. Broad expression in testis (RPKM 47.5), thyroid (RPKM 18.5) and 25 other tissues.

功能概要

该基因编码的蛋白质是中心粒卫星的组成部分，中心粒卫星是散布在中心体周围的电子致密颗粒。抑制研究表明，这种蛋白质对于几种中心体蛋白质的正确定位以及将微管锚定到中心体是必不可少的。涉及该基因的染色体畸变与甲状腺乳头状癌和多种血液系统恶性肿瘤相关，包括非典型慢性粒细胞白血病和 T 细胞淋巴瘤。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2015 年 10 月]

The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

PCM1 基因产物(32)

mRNA Protein Name
NM_001315507.2 NP_001302436.2 pericentriolar material 1 protein isoform 2
NM_001315508.2 NP_001302437.2 pericentriolar material 1 protein isoform 3
NM_001352632.2 NP_001339561.2 pericentriolar material 1 protein isoform 4
NM_001352633.2 NP_001339562.2 pericentriolar material 1 protein isoform 5
NM_001352634.2 NP_001339563.2 pericentriolar material 1 protein isoform 6
NM_001352635.2 NP_001339564.2 pericentriolar material 1 protein isoform 7
NM_001352636.2 NP_001339565.2 pericentriolar material 1 protein isoform 8
NM_001352637.2 NP_001339566.2 pericentriolar material 1 protein isoform 9
NM_001352638.2 NP_001339567.2 pericentriolar material 1 protein isoform 10
NM_001352639.2 NP_001339568.2 pericentriolar material 1 protein isoform 11
NM_001352640.2 NP_001339569.2 pericentriolar material 1 protein isoform 12
NM_001352641.2 NP_001339570.2 pericentriolar material 1 protein isoform 13
NM_001352642.2 NP_001339571.2 pericentriolar material 1 protein isoform 14
NM_001352643.2 NP_001339572.2 pericentriolar material 1 protein isoform 15
NM_001352644.2 NP_001339573.2 pericentriolar material 1 protein isoform 16
NM_001352645.2 NP_001339574.2 pericentriolar material 1 protein isoform 16
NM_001352646.2 NP_001339575.2 pericentriolar material 1 protein isoform 17
NM_001352647.2 NP_001339576.2 pericentriolar material 1 protein isoform 17
NM_001352648.2 NP_001339577.2 pericentriolar material 1 protein isoform 18
NM_001352649.2 NP_001339578.2 pericentriolar material 1 protein isoform 18
NM_001352650.2 NP_001339579.2 pericentriolar material 1 protein isoform 19
NM_001352651.2 NP_001339580.2 pericentriolar material 1 protein isoform 19
NM_001352652.2 NP_001339581.2 pericentriolar material 1 protein isoform 1
NM_001352653.2 NP_001339582.2 pericentriolar material 1 protein isoform 1
NM_001352654.2 NP_001339583.2 pericentriolar material 1 protein isoform 21
NM_001352655.2 NP_001339584.2 pericentriolar material 1 protein isoform 21
NM_001352656.2 NP_001339585.2 pericentriolar material 1 protein isoform 21
NM_001352657.2 NP_001339586.2 pericentriolar material 1 protein isoform 22
NM_001352658.2 NP_001339587.2 pericentriolar material 1 protein isoform 22
NM_001352659.2 NP_001339588.2 pericentriolar material 1 protein isoform 23
NM_001352660.2 NP_001339589.2 pericentriolar material 1 protein isoform 23
NM_006197.4 NP_006188.4 pericentriolar material 1 protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables molecular adaptor activity IDA
IDA: 通过直接分析推断
34782749 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9361024 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in centrosome cycle IMP
IMP: 通过突变表型推断
17574030 GOA
involved in cilium assembly IMP
IMP: 通过突变表型推断
15616553 GOA
acts upstream of or within cytoplasmic microtubule organization IMP
IMP: 通过突变表型推断
24816561 GOA
involved in cytoplasmic microtubule organization IMP
IMP: 通过突变表型推断
22797915 GOA
involved in intraciliary transport involved in cilium assembly IMP
IMP: 通过突变表型推断
24550735 GOA
involved in non-motile cilium assembly IMP
IMP: 通过突变表型推断
23789104 GOA
involved in positive regulation of intracellular protein transport IMP
IMP: 通过突变表型推断
22797915 GOA
acts upstream of or within protein localization to centrosome IMP
IMP: 通过突变表型推断
24816561 GOA
involved in protein-containing complex localization to centriolar satellite IDA
IDA: 通过直接分析推断
34782749 GOA
involved in regulation of protein complex stability IDA
IDA: 通过直接分析推断
34782749 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in centriolar satellite IDA
IDA: 通过直接分析推断
34782749 GOA
located in centriolar satellite IDA
IDA: 通过直接分析推断
15616553 GOA
colocalizes with centrosome IDA
IDA: 通过直接分析推断
24648492 GOA
located in centrosome IDA
IDA: 通过直接分析推断
20719959 GOA
located in ciliary transition zone IDA
IDA: 通过直接分析推断
24415959 GOA
NOT located in non-motile cilium IDA
IDA: 通过直接分析推断
17574030 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
24421332 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

pericentriolar material 1 protein

PCM-1

PCM1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PCM1 Q15154 BBS4 Homo sapiens Q96RK4
Anti Tag CoIP
15107855
种属内
PCM1 Q15154 BBS4 Homo sapiens Q96RK4
Y2H
15107855
种属内
PCM1 Q15154 BBS4 Homo sapiens Q96RK4
Anti Tag CoIP
22500027
种属内
PCM1 Q15154 BBS4 Homo sapiens Q96RK4
Confocal
15107855
种属内
PCM1 Q15154 MIB1 Homo sapiens Q86YT6
Anti Tag CoIP
33961781
种属内
PCM1 Q15154 MIB1 Homo sapiens Q86YT6
BioID
26638075
种属内
PCM1 Q15154 MIB1 Homo sapiens Q86YT6
Anti Tag CoIP
26638075
种属内
PCM1 Q15154 SSX2IP Homo sapiens Q9Y2D8
BioID
26638075
种属内
PCM1 Q15154 SSX2IP Homo sapiens Q9Y2D8
Anti Tag CoIP
26638075
种属内
PCM1 Q15154 CEP131 Homo sapiens Q9UPN4
Anti Tag CoIP
26638075
种属内
PCM1 Q15154 CEP131 Homo sapiens Q9UPN4
Anti Bait CoIP
26297806
种属内
PCM1 Q15154 CEP131 Homo sapiens Q9UPN4
BioID
26638075
种属内
PCM1 Q15154 PIBF1 Homo sapiens Q8WXW3
BioID
26638075
种属内
PCM1 Q15154 PIBF1 Homo sapiens Q8WXW3
Anti Tag CoIP
26638075
种属内
PCM1 Q15154 PIBF1 Homo sapiens Q8WXW3
Anti Bait CoIP
26297806
种属内
PCM1 Q15154 KIAA0753 Homo sapiens Q2KHM9
Anti Tag CoIP
26638075
种属内
PCM1 Q15154 KIAA0753 Homo sapiens Q2KHM9
Anti Bait CoIP
26297806
种属内
PCM1 Q15154 KIAA0753 Homo sapiens Q2KHM9
BioID
26638075
种属内
PCM1 Q15154 YWHAZ Homo sapiens P63104
Pull Down
15161933
种属内
PCM1 Q15154 YWHAE Homo sapiens P62258
Crosslink
36931259
种属内
PCM1 Q15154 SPAG5 Homo sapiens Q96R06
Anti Bait CoIP
26297806
种属内
PCM1 Q15154 PCNT Homo sapiens O95613
Anti Bait CoIP
24816561
种属内
PCM1 Q15154 PCNT Homo sapiens O95613
Anti Tag CoIP
26638075
种属内
PCM1 Q15154 GABARAP Homo sapiens O95166
Peptide Array
28712572
种属内
PCM1 Q15154 WASHC3 Homo sapiens Q9Y3C0
Y2H Array
31515488
种属内
PCM1 Q15154 WASHC3 Homo sapiens Q9Y3C0
Y2H Pooling
16189514
种属内
PCM1 Q15154 OFD1 Homo sapiens O75665
BioID
26638075
种属内
PCM1 Q15154 OFD1 Homo sapiens O75665
Anti Tag CoIP
26638075
种属内
PCM1 Q15154 CEP72 Homo sapiens Q9P209
Y2H Array
31515488
种属内
PCM1 Q15154 CEP72 Homo sapiens Q9P209
Anti Bait CoIP
26297806
种属内
PCM1 Q15154 CEP72 Homo sapiens Q9P209
BioID
26638075
种属内
PCM1 Q15154 CEP72 Homo sapiens Q9P209
Anti Tag CoIP
26638075
种属内
PCM1 Q15154 CEP72 Homo sapiens Q9P209
Y2H Pooling
16189514
种属内
PCM1 Q15154 ABI2 Homo sapiens Q9NYB9
Y2H Array
29892012
种属内
PCM1 Q15154 ABI2 Homo sapiens Q9NYB9
Y2H Pooling
16189514
种属内
PCM1 Q15154 CCDC14 Homo sapiens Q49A88
BioID
26638075
种属内
PCM1 Q15154 CCDC14 Homo sapiens Q49A88
Anti Bait CoIP
26297806
种属内
PCM1 Q15154 CCDC14 Homo sapiens Q49A88
Anti Tag CoIP
26638075
种属间
PCM1 Q15154 Hap1 Rattus norvegicus P54256
Y2H
9361024
种属间
PCM1 Q15154 Hap1 Rattus norvegicus P54256
Pull Down
9361024
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Differentiated Thyroid Carcinoma

Papillary Or Follicular Thyroid Carcinoma

Well-Differentiated Thyroid Carcinoma

Differentiated Thyroid Gland Carcinoma
Bardet-Biedl Syndrome 4

BBS4

Bardet-Biedl Syndrome, Type 4
Myeloid Leukemia

Myeloid Leukaemia

Leukaemia Myelogenous

Leukemia Myelogenous

Myeloid Granulocytic Leukaemia

Myeloid Granulocytic Leukemia

Non-Lymphocytic Leukemia

Leukemia, Myeloid

Granulocytic Leukaemia

Myelogenous Leukaemia

Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos
Neurosyphilis

Syphilis Of Central Nervous System

Late Syphilis Of Central Nervous System Nos

Late Syphilis Of The Central Nervous System

Gumma Of Central Nervous System

Neurosyphilis Gumma

Neurosyphilitic Gumma

Syphilis Of Central Nervous System Nos

Syphilitic Gumma Of Central Nervous System

Tertiary Central Nervous System Syphilis
Bardet-Biedl Syndrome

Bbs

Biedl-Bardet Syndrome
Huntington Disease

Huntington'S Disease

Huntington Chorea

Huntington'S Chorea

HD

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Joubert Syndrome 1

Joubert Syndrome

Jbts

Cerebellooculorenal Syndrome 1

JBTS1

Joubert-Boltshauser Syndrome

Cerebelloparenchymal Disorder Iv

Cpd4

Cors1

Joubert Syndrome And Related Disorders

Jsrd

Familial Aplasia Of The Vermis

Joubert Syndrome Related Disorders

Js

Cerebellar Vermis Agenesis

Cerebelloparenchymal Disorder 4

Agenesis Of Cerebellar Vermis

Cerebello-Oculo-Renal Syndrome

Cors

Joubert-Bolthauser Syndrome

Cpd Iv

Classic Joubert Syndrome

Joubert Syndrome Type A

Pure Joubert Syndrome

Cerebello-Oculo-Renal Syndrome 1

Joubert Syndrome-1

Joubert Syndrome, Type 1

Joubert'S Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10156 PCM1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PCM1 VGNC VGNC:78544
Mus musculus PCM1 MGD MGI:1277958
Rattus norvegicus PCM1 RGD RGD:620901
Macaca mulatta PCM1 VGNC VGNC:75781
Canis familiaris PCM1 VGNC VGNC:44309
Bos taurus PCM1 VGNC VGNC:32634
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