2. Gene
  3. MIB1 - MIB E3 ubiquitin protein ligase 1 Gene

MIB1 - MIB E3 ubiquitin protein ligase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MIB E3 泛素蛋白连接酶 1

种属: Homo sapiens

同用名: MIB; DIP1; ZZZ6; DIP-1; LVNC7; ZZANK2

基因 ID: 57534 | 基因类型: protein coding

关于 MIB1

Cytogenetic location: 18q11.2 Genomic coordinates (GRCh38): 18:21,704,916-21,870,953 (from NCBI)

This gene has 6 transcripts (splice variants), 207 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 7.2), endometrium (RPKM 6.4) and 25 other tissues.

功能概要

该基因编码的蛋白质包含多个锚蛋白重复序列和 RING 指结构域，可作为 E3 泛素连接酶发挥作用。编码的蛋白质通过泛素化 Notch 受体正向调节 Notch 信号，从而促进它们的内吞作用。这种蛋白质还可以促进死亡相关蛋白激酶 1 (DAPK1) 的泛素化和降解。[RefSeq 提供，2013 年 6 月]

This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin Ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013]

MIB1 基因产物(1)

mRNA Protein Name
NM_020774.4 NP_065825.1 E3 ubiquitin-protein ligase MIB1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21903422 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
23615451 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
21399614 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MIB1 蛋白结构

MIB_HERC2

MIB_HERC2: Mib_herc2 (15 - 74)

ZZ

ZZ: Zinc finger, ZZ type (80 - 119)

MIB_HERC2

MIB_HERC2: Mib_herc2 (154 - 220)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (435 - 527)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (531 - 593)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (596 - 662)

Ank

Ank: Ankyrin repeat (666 - 697)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (817 - 859)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (864 - 906)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (960 - 1001)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1006 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase MIB1

DAPK-interacting protein 1

MIB1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Cross MIB1 Q86YT6 P0DTD1-PRO_0000449627 SARS-CoV-2 P0DTD1-PRO_0000449627
Y2H Array
36217030
Cross MIB1 Q86YT6 Azi2 Mus musculus Q9QYP6
Anti Tag CoIP
21903422
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Left Ventricular Noncompaction 7

LVNC7

Left Ventricular Non-Compaction 7

Ventricular Noncompaction, Left, Type 7
Left Ventricular Noncompaction

Noncompaction Cardiomyopathy

Left Ventricular Hypertrabeculation

Lvnc

Spongy Myocardium

Isolated Noncompaction Of The Ventricular Myocardium

Left Ventricular Myocardial Noncompaction Cardiomyopathy

Fetal Myocardium

Honeycomb Myocardium

Hypertrabeculation Syndrome

Left Ventricular Non-Compaction

Lvht

Non-Compaction Of The Left Ventricular Myocardium

Ventricular Noncompaction, Left

Non-Compaction Cardiomyopathy
Lymphoplasmacyte-Rich Meningioma

Lymphoplasmocyte-Rich Meningioma

Meningioma
Microcystic Meningioma
Juxtacortical Chondroma

Periosteal Chondroma
Diffuse Meningeal Melanocytosis

Diffuse Melanocytosis

Diffuse Melanosis
Foster-Kennedy Syndrome

Disorder Of The Optic Nerve

Optic Nerve Diseases

Disease Of Optic Cranial Nerve

Disease Of Optic Nerve

Disease Of Second Cranial Nerve

Disorder Of Optic Cranial Nerve

Disorder Of Second Cranial Nerve

Disorders Of 2nd Nerve
Meningeal Melanocytoma

Leptomeningeal Melanocytoma

Melanocytoma Of Meninges
Central Nervous System Melanocytic Neoplasm

Primary Melanocytic Lesion Of Meninges

Central Nervous System Primary Melanocytic Lesion

Melanocytic Tumor Of The Cns

Primary Melanocytic Lesions Of The Cns
Spinal Meningioma

Spinal Cord Meningioma

Meningioma, Spine

Meningioma

Meningioma, Benign, No Icd-O Subtype
Spinal Canal And Spinal Cord Meningioma
Intracranial Meningioma

Meningioma
Optic Nerve Glioma

Glioma Of The Optic Nerve
Epilepsy

Epilepsy Syndrome

Epileptic Syndrome

Epilepsies

Symptomatic Epilepsies

Post Traumatic Epilepsy

Traumatic Epilepsy

Traumatic Epileptic

Epilepsy Due To Hippocampal Sclerosis

Epilepsy With Ammon'S Horn Sclerosis

Epilepsy Due To Cortical Dysplasia

Epilepsy Due To Neuronal Migration Disorders
Optic Nerve Neoplasm

Optic Nerve Neoplasms

Neoplasm Of Optic Nerve

Tumor Of Second Cranial Nerve

Tumour Of Optic Nerve
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08422 MIB1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus MIB1 MGD MGI:2443157
Rattus norvegicus MIB1 RGD RGD:1307195
Bos taurus MIB1 VGNC VGNC:31455
Macaca mulatta MIB1 VGNC VGNC:104228
Canis familiaris MIB1 VGNC VGNC:43217
Felis catus MIB1 VGNC VGNC:63492
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