PIBF1 - progesterone immunomodulatory binding factor 1 Gene

中文名称：黄体酮免疫调节结合因子 1

种属: Homo sapiens

同用名: PIBF; CEP90; JBTS33; C13orf24

基因 ID: 10464 | 基因类型: protein coding

关于 PIBF1

Cytogenetic location: 13q21.33-q22.1 Genomic coordinates (GRCh38): 13:72,782,133-73,016,461 (from NCBI)

This gene has 8 transcripts (splice variants), 216 orthologues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 9.0), testis (RPKM 8.7) and 25 other tissues.

功能概要

该基因编码一种由类固醇激素黄体酮诱导并在维持妊娠中发挥作用的蛋白质。编码的蛋白质调节免疫系统的多个方面以促进正常妊娠，包括细胞因子合成、自然杀伤 (NK) 细胞活性和花生四烯酸代谢。这种蛋白质的低血清水平与人类的自发性早产有关。该蛋白可能促进胶质瘤的增殖、迁移和侵袭。[RefSeq 提供，2017 年 3 月]

This gene encodes a protein that is induced by the steroid hormone progesterone and plays a role in the maintenance of pregnancy. The encoded protein regulates multiple facets of the immune system to promote normal pregnancy including cytokine synthesis, natural killer (NK) cell activity, and arachidonic acid metabolism. Low serum levels of this protein have been associated with spontaneous pre-term labor in humans. This protein may promote the proliferation, migration and invasion of glioma. [provided by RefSeq, Mar 2017]

PIBF1 基因产物(2)

mRNA	Protein	Name
NM_001349655.2	NP_001336584.1	progesterone-induced-blocking factor 1 isoform 1
NM_006346.4	NP_006337.2	progesterone-induced-blocking factor 1 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables interleukin-4 receptor binding	IDA IDA: 通过直接分析推断	16393965	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17500595	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in activation of Janus kinase activity	IDA IDA: 通过直接分析推断	16393965	GOA
involved in cilium assembly	IMP IMP: 通过突变表型推断	26167768	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: 通过突变表型推断	21224392	GOA
involved in mitotic spindle assembly	IMP IMP: 通过突变表型推断	21224392	GOA
involved in negative regulation of interleukin-12 production	IDA IDA: 通过直接分析推断	14634107	GOA
involved in negative regulation of natural killer cell activation	IDA IDA: 通过直接分析推断	12516630	GOA
involved in negative regulation of prostaglandin biosynthetic process	IDA IDA: 通过直接分析推断	3863495	GOA
involved in negative regulation of tyrosine phosphorylation of STAT protein	IDA IDA: 通过直接分析推断	16393965	GOA
involved in non-motile cilium assembly	IMP IMP: 通过突变表型推断	23110211	GOA
involved in positive regulation of interleukin-10 production	IDA IDA: 通过直接分析推断	14634107	GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein	IDA IDA: 通过直接分析推断	16393965	GOA
involved in protein localization to centrosome	IMP IMP: 通过突变表型推断	23110211	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in centriolar satellite	IDA IDA: 通过直接分析推断	21224392	GOA
located in centrosome	IDA IDA: 通过直接分析推断	21399614	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	14634107	GOA
located in nucleus	IDA IDA: 通过直接分析推断	14634107	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

progesterone-induced-blocking factor 1

centrosomal protein of 90 kDa

PIBF1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	PIBF1	Q8WXW3	HTT	Homo sapiens	P42858	Y2H	17500595
Intra	PIBF1	Q8WXW3	PCM1	Homo sapiens	Q15154	Anti Tag CoIP	26297806
Intra	PIBF1	Q8WXW3	CEP63	Homo sapiens	Q96MT8	Anti Bait CoIP	26297806
Intra	PIBF1	Q8WXW3	CEP63	Homo sapiens	Q96MT8	Anti Tag CoIP	26297806

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Joubert Syndrome 33

JBTS33

Joubert Syndrome, Type 33

Encephalocele

Cephalocele	Craniocele
Bifid Cranium	Cranium Bifidum
Encephaloceles

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Dandy-Walker Syndrome

Dandy-Walker Malformation	DWS
Atresia Of Foramina Of Magendie And Luschka	Dandy-Walker Complex
Dandy-Walker Cyst	Dandy-Walker Deformity
Dandy Walker Cyst	Dw Complex
Dandy-Walker Syndrome Or Malformation	Dandy-Walker Variant
Mega Cisterna Magna	Dwm
Hydrocephalus, Internal, Dandy-Walker Type	Hydrocephalus, Noncommunicating, Dandy-Walker Type
Luschka-Magendie Foramina Atresia	Isolated Dandy-Walker Malformation
Mega-Cisterna Magna	Dandy Walker Variant
Atresia Of Foramen Of Luschka	Atresia Of Foramen Of Magendie
Congenital Blockage Of Foramen Magendie

Breast Lymphoma

Lymphoma Of Breast	Lymphoma Of The Breast
Malignant Lymphoma Of Breast

Placental Abruption

Abruptio Placentae	Abruptio Placenta
Abortion, Threatened	Threatened Miscarriage
Haemorrhage Specified As Due To Threatened Abortion	Spontaneous Threatened Abortion

Pregnancy Loss, Recurrent 1

Pregnancy Loss, Recurrent, Susceptibility To, 1	Rpl
RPRGL1	Rprgl
Recurrent Miscarriage	Recurrent Spontaneous Abortion
Abortion, Spontaneous, Recurrent	Fetal Loss, Recurrent
Fetal Loss, Recurrent, Susceptibility To	Miscarriage, Recurrent
Embryonic Loss, Recurrent	Stillbirth, Recurrent
Pregnancy Loss, Recurrent, 1	Recurrent Embryonic Loss
Recurrent Fetal Loss	Recurrent Stillbirth
Spontaneous Recurrent Abortion	Miscarriage Recurrent
Pregnancy Loss, Recurrent, Susceptibility To, Type 1	Abortion, Habitual

Fraser Syndrome 2

FRASRS2

Nephronophthisis 16

NPHP16

Nephronophthisis, Type 16

Nephronophthisis 9

NPHP9

Nephronophthisis, Type 9

Bainbridge-Ropers Syndrome

BRPS	Severe Feeding Difficulties-Failure To Thrive-Microcephaly Due To Asxl3 Deficiency Syndrome
Asxl3-Related Disorder

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10477	PIBF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	PIBF1	RGD	RGD:1305077
Bos taurus	PIBF1	VGNC	VGNC:32859
Canis familiaris	PIBF1	VGNC	VGNC:44523
Felis catus	PIBF1	VGNC	VGNC:64161
Mus musculus	PIBF1	MGD	MGI:1261910

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PIBF1 - progesterone immunomodulatory binding factor 1 Gene

关于 PIBF1

功能概要

PIBF1 基因产物(2)

PIBF1 蛋白互作信息

关联疾病

直系同源

热门区域

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PIBF1 - progesterone immunomodulatory binding factor 1 Gene

关于 PIBF1

功能概要

PIBF1 基因产物(2)

PIBF1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z