Hap1 - huntingtin-associated protein 1 Gene

种属: Rattus norvegicus

同用名: HAP1-A; HAP1-B

基因 ID: 29430 | 基因类型: protein coding

关于 Hap1

功能概要

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein Huntingtin. This gene encodes a protein that is homologous to the human huntingtin-associated protein 1. The human protein interacts with Huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Two transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Hap1 基因产物(2)

mRNA	Protein	Name
NM_024133.4	NP_077047.2	huntingtin-associated protein 1 isoform A
NM_177982.3	NP_817091.2	huntingtin-associated protein 1 isoform B

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables brain-derived neurotrophic factor binding	IDA IDA: 通过直接分析推断	19996106	RGD
enables identical protein binding	IPI IPI: 通过物理相互作用推断	9361024	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	9285789	RGD
enables protein domain specific binding	IPI IPI: 通过物理相互作用推断	12873381	RGD
enables signaling receptor binding	IPI IPI: 通过物理相互作用推断	12873381	RGD
enables transmembrane transporter binding	IDA IDA: 通过直接分析推断	12873381	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in anterograde axonal transport	IMP IMP: 通过突变表型推断	19996106	RGD
involved in cellular response to growth factor stimulus	IEP IEP: 通过表达模式推断	10924259	RGD
involved in negative regulation of amyloid-beta formation	IMP IMP: 通过突变表型推断	22731248	RGD
involved in neuron projection development	IDA IDA: 通过直接分析推断	17166838	RGD
involved in positive regulation of epidermal growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	12890790	RGD
involved in positive regulation of inclusion body assembly	IDA IDA: 通过直接分析推断	9798945	RGD
involved in positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	IDA IDA: 通过直接分析推断	12873381	RGD
involved in positive regulation of neuron projection development	IDA IDA: 通过直接分析推断	10924259	RGD
involved in positive regulation of neurotrophin production	IDA IDA: 通过直接分析推断	21357693	RGD
involved in positive regulation of neurotrophin production	IMP IMP: 通过突变表型推断	19996106	RGD
involved in positive regulation of synaptic transmission, GABAergic	IDA IDA: 通过直接分析推断	20152113	RGD
involved in positive regulation of synaptic transmission, GABAergic	IMP IMP: 通过突变表型推断	20152113	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: 通过直接分析推断	15310851	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IEP IEP: 通过表达模式推断	15310851	RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization	IMP IMP: 通过突变表型推断	15310851	RGD
involved in retrograde axonal transport	IMP IMP: 通过突变表型推断	19996106	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in GABA-ergic synapse	IDA IDA: 通过直接分析推断	15310851	RGD
is active in GABA-ergic synapse	IMP IMP: 通过突变表型推断	15310851	RGD
located in axon terminus	IDA IDA: 通过直接分析推断	10924259	RGD
located in cytoplasm	IDA IDA: 通过直接分析推断	17166838	RGD
located in dendrite	IDA IDA: 通过直接分析推断	10924259	RGD
located in growth cone	IDA IDA: 通过直接分析推断	10924259	RGD
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	10924259	RGD
is active in postsynaptic cytosol	IDA IDA: 通过直接分析推断	9742138	RGD
is active in presynaptic cytosol	IDA IDA: 通过直接分析推断	9742138	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

huntingtin-associated protein 1

HAP-1

Hap1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	Hap1	P54256	HTT	Homo sapiens	P42858	Y2H	9798945
种属内	Hap1	P54256	HTT	Homo sapiens	P42858	Pull Down	18615096
种属内	Hap1	P54256	Hgs	Rattus norvegicus	Q9JJ50	Y2H	12021262
种属内	Hap1	P54256	Hgs	Rattus norvegicus	Q9JJ50	Confocal	12021262
种属内	Hap1	P54256	DCTN1	Homo sapiens	Q14203	Pull Down	18615096
种属内	Hap1	P54256	DCTN1	Homo sapiens	Q14203	Y2H	9361024
种属内	Hap1	P54256	PCM1	Homo sapiens	Q15154	Y2H	9361024
种属内	Hap1	P54256	Hap1	Rattus norvegicus	P54256	Y2H	9361024
种属内	Hap1	P54256	Hap1	Rattus norvegicus	P54256	Y2H	9798945
种属内	Hap1	P54256	KIF5B	Homo sapiens	P33176	Pull Down	18615096
种属内	Hap1	P54256	Kif5a	Mus musculus	P33175	Pull Down	20152113

种属间: 跨种属相互作用 种属内: 同种属相互作用

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-150221	DB008	Inhibitor	98.78%	否
HY-P4096	HAP-1		/	否
HY-RS06000	HAP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Hap1	NCBI	NCBI:9001

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Hap1 - huntingtin-associated protein 1 Gene

关于 Hap1

功能概要

Hap1 基因产物(2)

Hap1 蛋白互作信息

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

Hap1 - huntingtin-associated protein 1 Gene

关于 Hap1

功能概要

Hap1 基因产物(2)

Hap1 蛋白互作信息

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z