2. Epigenetics
  3. Histone Methyltransferase
  4. PRMT5-IN-34

PRMT5-IN-34 (Compound C) 是 MTA-cooperative 蛋白质精氨酸甲基转移酶 5 (PRMT5/MAT) 的抑制剂。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PRMT5-IN-34 Chemical Structure

PRMT5-IN-34 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

PRMT5-IN-34 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PRMT5-IN-34 (Compound C) is an inhibitor of MTA-cooperative Protein arginine methyltransferase 5 (PRMT5/MAT)[1].

IC50 & Target[1]

PRMT5

 

体外研究
(In Vitro)

PRMT5-IN-34 对各个细胞的抑制增殖活性效果分别为 IC50=0.827 μM (HDLM2); 0.252 μM (L540); 0.077 μM (L1236); 4.638 μM (L428); 0.170 μM (HCT116); 8.538 μM (HCT116)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PRMT5-IN-34 相关抗体:
体内研究
(In Vivo)

PRMT5-IN-34 (p.o.; 25-100 mg/kg; 每天一次,持续21 天) 抑制 MTAP 沉默的 L540HL 异种移植老鼠模型中的肿瘤生长，SDMA蛋白水平减少[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MTAP silenced L540 HL xenograft model [1]
Dosage: 25; 50; 100 mg/kg
Administration: p.o. once daily for 21 days
Result: Concentration-dependently inhibited tumor growth (22%, 52%, 93%). Concentration-dependently decreased the protein level of SDMA (83.9%, 97.6%, 99.1%).
分子量

435.43

Formula

C23H19F2N5O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PRMT5-IN-34 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PRMT5-IN-34Histone Methyltransferasecancer L540 HL xenograft modelInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
PRMT5-IN-34
目录号：
HY-158143
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z