2. Gene
  3. DRG2 - developmentally regulated GTP binding protein 2 Gene

DRG2 - developmentally regulated GTP binding protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：发育调节的 GTP 结合蛋白 2

种属: Homo sapiens

基因 ID: 1819 | 基因类型: protein coding

关于 DRG2

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:18,087,948-18,107,969 (from NCBI)

This gene has 21 transcripts (splice variants), 215 orthologues and 4 paralogues. Ubiquitous expression in ovary (RPKM 11.9), prostate (RPKM 10.9) and 25 other tissues.

功能概要

该基因编码一种 GTP 结合蛋白，已知其在细胞生长和分化的调节中发挥作用。已鉴定出包含该基因和下游基因的通读转录本，但不认为它们编码融合蛋白。该基因位于 17 号染色体上的 Smith-Magenis 综合征区域内。[RefSeq 提供，2012 年 1 月]

This gene encodes a GTP-binding protein known to function in the regulation of cell growth and differentiation. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jan 2012]

DRG2 基因产物(2)

mRNA Protein Name
NM_001330144.2 NP_001317073.1 developmentally-regulated GTP-binding protein 2 isoform 2
NM_001388.5 NP_001379.1 developmentally-regulated GTP-binding protein 2 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activity IDA
IDA: 通过直接分析推断
29915238 GOA
enables RNA binding IDA
IDA: 通过直接分析推断
29915238 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
29915238 GOA
located in nucleus IDA
IDA: 通过直接分析推断
29915238 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DRG2 蛋白结构

MMR_HSR1

MMR_HSR1: 50S ribosome-binding GTPase (64 - 155)

TGS

TGS: TGS domain (291 - 363)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
蛋白主名 其他名称

developmentally-regulated GTP-binding protein 2

TRAFAC GTPase DRG2

DRG2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DRG2 P55039 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
种属内
DRG2 P55039 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
种属内
DRG2 P55039 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
种属内
DRG2 P55039 TSSK3 Homo sapiens Q96PN8
Validated Y2H
32296183
种属内
DRG2 P55039 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
种属内
DRG2 P55039 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
种属内
DRG2 P55039 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
种属内
DRG2 P55039 RWDD1 Homo sapiens Q9H446
Anti Tag CoIP
33961781
种属内
DRG2 P55039 RWDD1 Homo sapiens Q9H446
Validated Y2H
25416956
种属内
DRG2 P55039 RWDD1 Homo sapiens Q9H446
Y2H Pooling
16189514
种属内
DRG2 P55039 RWDD1 Homo sapiens Q9H446
Anti Tag CoIP
28514442
种属内
DRG2 P55039 RWDD1 Homo sapiens Q9H446
Validated Y2H
32296183
种属内
DRG2 P55039 RWDD1 Homo sapiens Q9H446
Y2H Array
32296183
种属内
DRG2 P55039 RWDD1 Homo sapiens Q9H446
Y2H Prey Pooling
32296183
种属内
DRG2 P55039 NAB2 Homo sapiens Q15742
Validated Y2H
32296183
种属内
DRG2 P55039 NAB2 Homo sapiens Q15742
Y2H Array
32296183
种属内
DRG2 P55039 NAB2 Homo sapiens Q15742
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Smith-Magenis Syndrome

SMS

Chromosome 17p11.2 Deletion Syndrome

17p11.2 Microdeletion Syndrome

17p11.2 Monosomy

Chromosome 17p Deletion Syndrome

Del(17)

P11.2

17p- Syndrome

Deletion 17p Syndrome

Partial Monosomy 17p
Volkmann Contracture

Ischemic Contracture

Volkmann'S Ischemic Contracture
Radial Neuropathy
Potocki-Lupski Syndrome

PTLS

Chromosome 17p11.2 Duplication Syndrome

17p11.2 Microduplication Syndrome

Duplication 17p11.2 Syndrome

Trisomy 17p11.2

Potocki-Lupski Syndrome (Dup(17)(P11.2p11.2))

17p11.2 Duplication Syndrome

Dup(17)(P11.2p11.2)

Pls

Chromosome 17, Trisomy 17p11 2
Craniometaphyseal Dysplasia, Autosomal Dominant

Craniometaphyseal Dysplasia

CMDD

Cmdj

Cmd

Autosomal Dominant Craniometaphyseal Dysplasia

Craniometaphyseal Dysplasia, Jackson Type

Craniometaphyseal Dysplasia Jackson Type

Autosomal Recessive Craniometaphyseal Dysplasia

Cmdr

Dysplasia, Craniometaphyseal, Autosomal Dominant

Craniometaphyseal Dysplasia, Autosomal Recessive Type
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04010 DRG2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus DRG2 VGNC VGNC:28209
Felis catus DRG2 VGNC VGNC:61631
Canis familiaris DRG2 VGNC VGNC:40098
Rattus norvegicus DRG2 RGD RGD:1562380
Mus musculus DRG2 MGD MGI:1342307
Macaca mulatta DRG2 VGNC VGNC:71993
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z