2. Cell Cycle/DNA Damage
  3. Eukaryotic Initiation Factor (eIF)
  4. eIF4A3-IN-17

eIF4A3-IN-17 (compound 61) 是 silvestrol (HY-13251) 类似物。eIF4A3-IN-17 干扰 eIF4F 翻译复合体组装，对 myc-LUC，tub-LUC 和抑制 MBA-MB-231 细胞生长的 EC50 值分别为 0.9，15 和 1.8 nM。eIF4A3-IN-17 可用于人类肿瘤发病机制的研究。

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eIF4A3-IN-17 Chemical Structure

eIF4A3-IN-17 Chemical Structure

CAS No. : 1402931-75-2

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eIF4A3-IN-17 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

eIF4A3-IN-17 (compound 61) is a silvestrol (HY-13251) analogue. eIF4A3-IN-17 interferes the assembling of eIF4F translation complex with EC50s of 0.9, 15 and 1.8 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-17 can be used for the research of human cancer pathogenesis[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MDA-MB-231 EC50
0.9 nM
Compound: 61
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
[PMID: 23025805]
MDA-MB-231 EC50
1.8 nM
Compound: 61
Growth inhibition of human MDA-MB-231 cells incubated for 72 hrs by MTS assay
Growth inhibition of human MDA-MB-231 cells incubated for 72 hrs by MTS assay
[PMID: 23025805]
MDA-MB-231 EC50
15 nM
Compound: 61
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
[PMID: 23025805]
分子量

487.50

Formula

C28H25NO7
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料
参考文献

eIF4A3-IN-17 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

eIF4A3-IN-171402931-75-2Eukaryotic Initiation Factor (eIF)myc-LUCtub-LUCMBA-MB-231natural producttranslationInhibitorinhibitorinhibit

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目录号：
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