1. Gene
  2. METTL13 - methyltransferase 13, eEF1A lysine and N-terminal methyltransferase Gene

METTL13 - methyltransferase 13, eEF1A lysine and N-terminal methyltransferase Gene

中文名称:甲基转移酶 13、eEF1A 赖氨酸和 N-末端甲基转移酶

种属: Homo sapiens

同用名: feat; DFNM1; CGI-01; DFNB26; DFNB26M; KIAA0859; EEF1AKNMT; 5630401D24Rik

基因 ID: 51603 | 基因类型: protein coding

关于 METTL13

Cytogenetic location: 1q24.3 Genomic coordinates (GRCh38): 1:171,781,660-171,797,716 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 10.7), lymph node (RPKM 7.3) and 25 other tissues.

功能概要

预测可启用甲基转移酶活性。参与细胞周期 G1/S 相转变的负调控和 RNA 聚合酶 II 转录的负调控。预测位于线粒体和细胞核中。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable methyltransferase activity. Involved in negative regulation of cell cycle G1/S phase transition and negative regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

METTL13 基因产物(3)

mRNA Protein Name
NM_001007239.2 NP_001007240.1 eEF1A lysine and N-terminal methyltransferase isoform 3
NM_014955.3 NP_055770.1 eEF1A lysine and N-terminal methyltransferase isoform 2
NM_015935.5 NP_057019.3 eEF1A lysine and N-terminal methyltransferase isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21516116 GOA
enables protein-lysine N-methyltransferase activity IDA
IDA: 通过直接分析推断
30143613 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

METTL13 蛋白结构

Methyltransf_11

Methyltransf_11: Methyltransferase domain (53 - 157)

Methyltransf_18

Methyltransf_18: Methyltransferase domain (497 - 614)

  • 0
  • 200
  • 400
  • 600
  • 699 a.a.
蛋白主名 其他名称

eEF1A lysine and N-terminal methyltransferase

antiapoptotic protein FEAT

METTL13 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra METTL13 Q8N6R0 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
Intra METTL13 Q8N6R0 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
Intra METTL13 Q8N6R0 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
Intra METTL13 Q8N6R0 KLK6 Homo sapiens Q92876
Y2H Array
32814053
Intra METTL13 Q8N6R0 KLK6 Homo sapiens Q92876
Validated Y2H
32814053
Intra METTL13 Q8N6R0 KLK6 Homo sapiens Q92876
Y2H Pooling
32814053
Intra METTL13 Q8N6R0 VPS52 Homo sapiens Q8N1B4
Validated Y2H
25416956
Intra METTL13 Q8N6R0 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
25416956
Intra METTL13 Q8N6R0 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra METTL13 Q8N6R0 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra METTL13 Q8N6R0 SNRPA Homo sapiens P09012
Validated Y2H
25416956
Intra METTL13 Q8N6R0 SNRPA Homo sapiens P09012
Y2H Prey Pooling
25416956
Intra METTL13 Q8N6R0 THAP1 Homo sapiens Q9NVV9
Validated Y2H
32296183
Intra METTL13 Q8N6R0 THAP1 Homo sapiens Q9NVV9
Y2H Array
32296183
Intra METTL13 Q8N6R0 THAP1 Homo sapiens Q9NVV9
Y2H Prey Pooling
32296183
Intra METTL13 Q8N6R0 THAP1 Homo sapiens Q9NVV9
Y2H
21516116
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Deafness, Autosomal Recessive 26, Modifier Of

Deafness, Nonsyndromic, Modifier 1

DFNB26M

Dfnb26, Modifier Of

Dfnb26, Suppressor Of

Deafness, Nonsyndromic, Modifier Of, 1

Dfnm1

{Deafness, Autosomal Recessive 26, Modifier Of}

Autosomal Dominant Nonsyndromic Deafness 74

Dfna74

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta METTL13 VGNC VGNC:72093
Felis catus METTL13 VGNC VGNC:61733
Rattus norvegicus METTL13 RGD RGD:1311526
Bos taurus METTL13 VGNC VGNC:31403
Mus musculus METTL13 MGD MGI:1918699