1. Gene
  2. CPSF7 - cleavage and polyadenylation specific factor 7 Gene

CPSF7 - cleavage and polyadenylation specific factor 7 Gene

中文名称:切割和聚腺苷酸化特异性因子 7

种属: Homo sapiens

同用名: CFIm59

基因 ID: 79869 | 基因类型: protein coding

关于 CPSF7

This gene has 26 transcripts (splice variants), 191 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 25.0), testis (RPKM 24.0) and 25 other tissues.

功能概要

切割因子 Im (CFIm) 是前体 mRNA 正确切割和聚腺苷酸化所必需的六个因子之一。 CFIm 由 25、59 和 68 kDa 的三个不同亚基组成,它作为异四聚体发挥作用,25 kDa 亚基的二聚体与 59 或 68 kDa 亚基中的两个结合。该基因编码的蛋白质代表 59 kDa 亚基,它可以与剪接因子 U2 snRNP 辅助因子 (U2AF) 65 相互作用以连接剪接和聚腺苷酸化复合物。[RefSeq 提供,2016 年 10 月]

Cleavage factor Im (CFIm) is one of six factors necessary for correct cleavage and polyadenylation of pre-mRNAs. CFIm is composed of three different subunits of 25, 59, and 68 kDa, and it functions as a heterotetramer, with a dimer of the 25 kDa subunit binding to two of the 59 or 68 kDa subunits. The protein encoded by this gene represents the 59 kDa subunit, which can interact with the splicing factor U2 snRNP Auxiliary Factor (U2AF) 65 to link the splicing and polyadenylation complexes. [provided by RefSeq, Oct 2016]

CPSF7 基因产物(3)

mRNA Protein Name
NM_001136040.4 NP_001129512.1 cleavage and polyadenylation specificity factor subunit 7 isoform 2
NM_001142565.3 NP_001136037.1 cleavage and polyadenylation specificity factor subunit 7 isoform 3
NM_024811.4 NP_079087.3 cleavage and polyadenylation specificity factor subunit 7 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway IDA
IDA: 通过直接分析推断
29276085 GOA
involved in mRNA 3'-end processing IDA
IDA: 通过直接分析推断
20695905 GOA
involved in mRNA alternative polyadenylation IMP
IMP: 通过突变表型推断
20695905 GOA
involved in protein heterotetramerization IDA
IDA: 通过直接分析推断
23187700 GOA
involved in protein tetramerization IDA
IDA: 通过直接分析推断
20695905 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19864460 GOA
part of mRNA cleavage and polyadenylation specificity factor complex IDA
IDA: 通过直接分析推断
23187700 GOA
part of mRNA cleavage factor complex IDA
IDA: 通过直接分析推断
20695905 GOA
part of mRNA cleavage factor complex IPI
IPI: 通过物理相互作用推断
20695905 GOA
located in nucleus IDA
IDA: 通过直接分析推断
19864460 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CPSF7 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (84 - 155)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 471 a.a.
蛋白主名 其他名称

cleavage and polyadenylation specificity factor subunit 7

CPSF 59 kDa subunit

CPSF7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CPSF7 Q8N684 RUNX1T1 Homo sapiens Q06455-4
Validated Y2H
25416956
种属内
CPSF7 Q8N684 SMAD3 Homo sapiens P84022
Validated Y2H
25416956
种属内
CPSF7 Q8N684 SMAD3 Homo sapiens P84022
Y2H Array
25416956
种属内
CPSF7 Q8N684 NUDT21 Homo sapiens O43809
Anti Tag CoIP
26496610
种属内
CPSF7 Q8N684 NUDT21 Homo sapiens O43809
Y2H Array
25416956
种属内
CPSF7 Q8N684 EPM2AIP1 Homo sapiens Q7L775
Y2H Prey Pooling
25416956
种属内
CPSF7 Q8N684 EPM2AIP1 Homo sapiens Q7L775
Validated Y2H
25416956
种属内
CPSF7 Q8N684 NCK2 Homo sapiens O43639
Y2H Prey Pooling
25416956
种属内
CPSF7 Q8N684 TLE5 Homo sapiens Q08117
Y2H Prey Pooling
25416956
种属内
CPSF7 Q8N684 U2AF2 Homo sapiens P26368
Y2H
17024186
种属内
CPSF7 Q8N684 U2AF2 Homo sapiens P26368
Pull Down
17024186
种属内
CPSF7 Q8N684 SEC23B Homo sapiens Q15437
Y2H Prey Pooling
25416956
种属内
CPSF7 Q8N684 SEC23B Homo sapiens Q15437
Validated Y2H
25416956
种属内
CPSF7 Q8N684 ARMC7 Homo sapiens Q9H6L4
Validated Y2H
25416956
种属内
CPSF7 Q8N684 ARMC7 Homo sapiens Q9H6L4
Y2H Prey Pooling
25416956
种属内
CPSF7 Q8N684 ARMC7 Homo sapiens Q9H6L4
Y2H Array
25416956
种属内
CPSF7 Q8N684 ATXN1 Homo sapiens P54253
Y2H Array
16713569
种属内
CPSF7 Q8N684 SNRNP25 Homo sapiens Q9BV90
Validated Y2H
25416956
种属内
CPSF7 Q8N684 SNRNP25 Homo sapiens Q9BV90
Y2H Prey Pooling
25416956
种属内
CPSF7 Q8N684 SNRNP25 Homo sapiens Q9BV90
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Mus musculus CPSF7 MGD MGI:1917826
Bos taurus CPSF7 VGNC VGNC:27675
Felis catus CPSF7 VGNC VGNC:61145
Macaca mulatta CPSF7 VGNC VGNC:71606
Rattus norvegicus CPSF7 RGD RGD:1305441
Canis familiaris CPSF7 VGNC VGNC:39578
Others CPSF7 NCBI