2. Gene
  3. SREK1 - splicing regulatory glutamic acid and lysine rich protein 1 Gene

SREK1 - splicing regulatory glutamic acid and lysine rich protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：剪接调节谷氨酸和富赖氨酸的蛋白质 1

种属: Homo sapiens

同用名: SFRS12; SRrp86; SRrp508

基因 ID: 140890 | 基因类型: protein coding

关于 SREK1

Cytogenetic location: 5q12.3 Genomic coordinates (GRCh38): 5:66,144,300-66,183,615 (from NCBI)

This gene has 16 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 19.8), thyroid (RPKM 10.9) and 25 other tissues.

功能概要

该基因编码含有 RNA 识别基序 (RRM) 结构域的富含丝氨酸/精氨酸 (SR) 剪接蛋白家族的成员。编码的蛋白质与其他 SR 蛋白质相互作用以调节剪接位点选择。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 7 月]

This gene encodes a member of a family of serine/arginine-rich (SR) splicing proteins containing RNA recognition motif (RRM) domains. The encoded protein interacts with Other SR proteins to modulate splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

SREK1 基因产物(8)

mRNA Protein Name
NM_001077199.3 NP_001070667.1 splicing regulatory glutamine/lysine-rich protein 1 isoform a
NM_001270492.2 NP_001257421.1 splicing regulatory glutamine/lysine-rich protein 1 isoform c
NM_001323527.2 NP_001310456.1 splicing regulatory glutamine/lysine-rich protein 1 isoform b
NM_001323529.2 NP_001310458.1 splicing regulatory glutamine/lysine-rich protein 1 isoform e
NM_001323533.2 NP_001310462.1 splicing regulatory glutamine/lysine-rich protein 1 isoform f
NM_001323534.2 NP_001310463.1 splicing regulatory glutamine/lysine-rich protein 1 isoform g
NM_001323535.2 NP_001310464.1 splicing regulatory glutamine/lysine-rich protein 1 isoform h
NM_139168.4 NP_631907.1 splicing regulatory glutamine/lysine-rich protein 1 isoform b
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
23602568 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SREK1 蛋白结构

(68 - 136)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 508 a.a.
蛋白主名 其他名称

splicing regulatory glutamine/lysine-rich protein 1

serine-arginine-rich splicing regulatory protein 508

SREK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SREK1 Q8WXA9 SRSF11 Homo sapiens Q05519
Validated Y2H
25416956
种属内
SREK1 Q8WXA9 SRSF11 Homo sapiens Q05519-2
Y2H Array
32296183
种属内
SREK1 Q8WXA9 SRSF11 Homo sapiens Q05519-2
Y2H Prey Pooling
32296183
种属内
SREK1 Q8WXA9 TXLNA Homo sapiens P40222
Y2H Prey Pooling
32296183
种属内
SREK1 Q8WXA9 TXLNA Homo sapiens P40222
Y2H Array
32296183
种属内
SREK1 Q8WXA9 GPRASP2 Homo sapiens Q96D09
Validated Y2H
32296183
种属内
SREK1 Q8WXA9 GPRASP2 Homo sapiens Q96D09
Y2H Prey Pooling
32296183
种属内
SREK1 Q8WXA9 GPRASP2 Homo sapiens Q96D09
Y2H Array
32296183
种属内
SREK1 Q8WXA9 SRPK1 Homo sapiens Q96SB4
Protein Kinase Assay
23602568
种属内
SREK1 Q8WXA9 SRPK2 Homo sapiens P78362
Protein Kinase Assay
23602568
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13759 SREK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus SREK1 VGNC VGNC:58417
Canis familiaris SREK1 VGNC VGNC:46797
Macaca mulatta SREK1 VGNC VGNC:77944
Mus musculus SREK1 MGD MGI:2145245
Rattus norvegicus SREK1 RGD RGD:621696
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