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  2. DDX46 - DEAD-box helicase 46 Gene

DDX46 - DEAD-box helicase 46 Gene

中文名称:死盒解旋酶 46

种属: Homo sapiens

同用名: Prp5; PRPF5

基因 ID: 9879 | 基因类型: protein coding

关于 DDX46

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:134,758,779-134,831,121 (from NCBI)

This gene has 12 transcripts (splice variants), 203 orthologues and 38 paralogues. Ubiquitous expression in appendix (RPKM 11.5), lymph node (RPKM 11.4) and 25 other tissues.

功能概要

该基因编码 DEAD box 蛋白家族的一个成员。以保守基序 Asp-Glu-Ala-Asp (DEAD) 为特征的 DEAD 盒蛋白是推定的 RNA 解旋酶。它们涉及许多涉及 RNA 二级结构改变的细胞过程,例如翻译起始、核和线粒体剪接以及核糖体和剪接体组装。根据它们的分布模式,该家族的一些成员被认为参与了胚胎发生、精子发生以及细胞生长和分裂。该基因编码的蛋白质是 17S U2 snRNP 复合体的组成部分;它在 pre-mRNA 剪接中起重要作用。已发现该基因的多个选择性剪接转录物变体。[RefSeq 提供,2014 年 7 月]

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]

DDX46 基因产物(2)

mRNA Protein Name
NM_001300860.2 NP_001287789.1 probable ATP-dependent RNA helicase DDX46 isoform 1
NM_014829.4 NP_055644.2 probable ATP-dependent RNA helicase DDX46 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22365833 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in U2-type prespliceosome assembly IDA
IDA: 通过直接分析推断
36797247 GOA
involved in mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
32494006 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of U2-type spliceosomal complex IDA
IDA: 通过直接分析推断
32494006 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

DDX46 蛋白结构

DEAD

DEAD: DEAD/DEAH box helicase (396 - 568)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (639 - 714)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1031 a.a.
蛋白主名 其他名称

probable ATP-dependent RNA helicase DDX46

DEAD (Asp-Glu-Ala-Asp) box polypeptide 46

DDX46 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DDX46 Q7L014 SRPK2 Homo sapiens P78362
Y2H
22365833
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Canis familiaris DDX46 VGNC VGNC:39859
Mus musculus DDX46 MGD MGI:1920895
Felis catus DDX46 VGNC VGNC:102184
Macaca mulatta DDX46 VGNC VGNC:71663
Bos taurus DDX46 VGNC VGNC:27969
Rattus norvegicus DDX46 RGD RGD:708480