1. Gene
  2. TRA2A - transformer 2 alpha homolog Gene

TRA2A - transformer 2 alpha homolog Gene

中文名称:变形金刚 2 alpha 同系物

种属: Homo sapiens

同用名: AWMS1; HSU53209

基因 ID: 29896 | 基因类型: protein coding

关于 TRA2A

Cytogenetic location: 7p15.3 Genomic coordinates (GRCh38): 7:23,504,780-23,531,981 (from NCBI)

This gene has 12 transcripts (splice variants), 214 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 46.2), endometrium (RPKM 25.7) and 25 other tissues.

功能概要

该基因是 transformer 2 同系物家族的成员,编码具有多个 RRM (RNA 识别基序) 结构域的蛋白质。这种磷酸化的核蛋白与特定的 RNA 序列结合,并在 pre-mRNA 剪接的调节中发挥作用。已发现该基因的可变剪接转录物变体。[RefSeq 提供,2013 年 9 月]

This gene is a member of the transformer 2 homolog family and encodes a protein with several RRM (RNA recognition motif) domains. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

TRA2A 基因产物(7)

mRNA Protein Name
NM_001282757.2 NP_001269686.1 transformer-2 protein homolog alpha isoform 2
NM_001282758.2 NP_001269687.1 transformer-2 protein homolog alpha isoform 2
NM_001282759.2 NP_001269688.1 transformer-2 protein homolog alpha isoform 3
NM_001362759.2 NP_001349688.1 transformer-2 protein homolog alpha isoform 4
NM_001362760.2 NP_001349689.1 transformer-2 protein homolog alpha isoform 2
NM_001362761.2 NP_001349690.1 transformer-2 protein homolog alpha isoform 2
NM_013293.5 NP_037425.1 transformer-2 protein homolog alpha isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
23602568 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
9546399 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
9546399 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TRA2A 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (123 - 191)

  • 0
  • 100
  • 200
  • 282 a.a.
蛋白主名 其他名称

transformer-2 protein homolog alpha

TRA-2 alpha

TRA2A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TRA2A Q13595 RNPS1 Homo sapiens Q15287
Validated Y2H
32296183
种属内
TRA2A Q13595 SRPK2 Homo sapiens P78362
Anti Tag CoIP
33961781
种属内
TRA2A Q13595 MAGOHB Homo sapiens Q96A72
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Malignant Pineal Area Germ Cell Neoplasm

Pineal Germ Cell Tumor

Malignant Pineal Parenchymal Germ Cell Tumor

Pineal Region Germ Cell Tumor

Pineal Cell Tumor

Pineal Cell Tumour

Pineal Region Germinoma

Malignant Pineal Region Germ Cell Tumor

Pineal Germinoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus TRA2A VGNC VGNC:36267
Mus musculus TRA2A MGD MGI:1933972
Canis familiaris TRA2A VGNC VGNC:47758
Macaca mulatta TRA2A VGNC VGNC:79040
Rattus norvegicus TRA2A RGD RGD:1562563
Felis catus TRA2A VGNC VGNC:66490