2. Gene
  3. SRSF6 - serine and arginine rich splicing factor 6 Gene

SRSF6 - serine and arginine rich splicing factor 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：富丝氨酸和精氨酸的剪接因子 6

种属: Homo sapiens

同用名: B52; SFRS6; SRP55; HEL-S-91

基因 ID: 6431 | 基因类型: protein coding

关于 SRSF6

Cytogenetic location: 20q13.11 Genomic coordinates (GRCh38): 20:43,457,896-43,464,243 (from NCBI)

This gene has 6 transcripts (splice variants), 260 orthologues and 8 paralogues. Ubiquitous expression in bone marrow (RPKM 64.4), prostate (RPKM 51.8) and 25 other tissues.

功能概要

该基因编码的蛋白质参与 mRNA 剪接，可能在决定可变剪接中发挥作用。编码的核蛋白属于剪接因子 SR 家族，已被证明与该家族的另一个成员 SFRS12 结合并对其进行调节。可变剪接导致多个转录本变体。此外，还发现了该基因的两个假基因，一个在 17 号染色体上，另一个在 X 染色体上。[RefSeq 提供，2010 年 9 月]

The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.[provided by RefSeq, Sep 2010]

SRSF6 基因产物(1)

mRNA Protein Name
NM_006275.6 NP_006266.2 serine/arginine-rich splicing factor 6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
24440982 GOA
enables pre-mRNA binding IDA
IDA: 通过直接分析推断
12549914 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in alternative mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
22767602 GOA
involved in mRNA splice site recognition IMP
IMP: 通过突变表型推断
12549914 GOA
involved in negative regulation of keratinocyte differentiation IMP
IMP: 通过突变表型推断
24440982 GOA
involved in negative regulation of mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
15009664 GOA
acts upstream of or within positive regulation of epithelial cell proliferation involved in lung morphogenesis IDA
IDA: 通过直接分析推断
23132731 GOA
acts upstream of or within regulation of alternative mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
23132731 GOA
involved in regulation of alternative mRNA splicing, via spliceosome IMP
IMP: 通过突变表型推断
24440982 GOA
involved in regulation of keratinocyte proliferation IMP
IMP: 通过突变表型推断
24440982 GOA
involved in regulation of wound healing IMP
IMP: 通过突变表型推断
24440982 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nuclear speck IDA
IDA: 通过直接分析推断
22767602 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SRSF6 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (4 - 64)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (112 - 177)

  • 0
  • 100
  • 200
  • 300
  • 344 a.a.
蛋白主名 其他名称

serine/arginine-rich splicing factor 6

SR splicing factor 6

SRSF6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SRSF6 Q13247 LUC7L2 Homo sapiens Q9Y383
Validated Y2H
25416956
Intra SRSF6 Q13247 LUC7L2 Homo sapiens Q9Y383
Validated Y2H
32296183
Intra SRSF6 Q13247 LUC7L2 Homo sapiens Q9Y383
Y2H Array
25416956
Intra SRSF6 Q13247 LUC7L2 Homo sapiens Q9Y383
Y2H Array
31515488
Intra SRSF6 Q13247 RNPS1 Homo sapiens Q15287
Y2H Pooling
16189514
Intra SRSF6 Q13247 SRPK1 Homo sapiens Q96SB4
Anti Tag CoIP
33961781
Intra SRSF6 Q13247 LUC7L Homo sapiens Q9NQ29-3
Validated Y2H
32296183
Intra SRSF6 Q13247 SRSF4 Homo sapiens Q08170
Y2H Array
31515488
Intra SRSF6 Q13247 SRSF4 Homo sapiens Q08170
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Plasmodium Malariae Malaria

Quartan Malaria

Malaria By Plasmodium Malariae

Nephrotic Syndrome Of Quartan Malaria

Malaria Nephrosis

Malarial Nephrosis

Nephrotic Syndrome In Malaria

Quartan Nephrosis
Aortitis
Cataract 30

Cataract 30 Pulverulent

Cataract Coppock-Like

Ctrct30

Dusty Cataract

Cataract, Type 30
Temporal Arteritis

Polymyalgia Rheumatica

Giant Cell Arteritis

Cranial Arteritis

Horton Disease

Gca

Horton'S Disease

Rhizomelic Pseudopolyarthritis

Arteritis Cranialis

Arteritis Temporalis

Horton'S Arteritis

Horton'S Giant Cell Arteritis

Horton'S Temporal Arteritis

Horton'S Syndrome

Gca - [Giant Cell Arteritis]

Senile Arthritis

Polymyalgia Arteritica

Pmr - [Polymyalgia Rheumatica]

Forestier-Certonciny Syndrome

Rheumatic Polymyalgia

Polymyalgia
Aortic Valve Insufficiency

Aortic Regurgitation

Rheumatic Aortic Regurgitation

Aortic Insufficiency

Rheumatic Aortic Insufficiency

Rheumatic Aortic Valve Insufficiency

Aortic Incompetence

Corrigan'S Disease

Rheumatic Aortic Valve Regurgitation

Aortic Valve Incompetency

Ai - [Aortic Incompetence]

Incompetent Aortic Valve

Ar - [Aortic Regurgitation]

Calcific Aortic Valve Regurgitation

Myxomatous Aortic Valve Regurgitation

Annular Incompetency Of Aortic Valve

Austin Flint Murmur

Flint Murmur

Rheumatic Aortic Incompetence

Rheumatic Ai - [Aortic Insufficiency]
Denys-Drash Syndrome

Drash Syndrome

DDS

Nephropathy, Wilms Tumor, And Genital Anomalies

Wilms Tumor And Pseudohermaphroditism

Wilms Tumor And Pseudo- Or True Hermaphroditism

Nephropathy Associated With Male Pseudohermaphroditism And Wilms' Tumor

Pseudohermaphroditism, Nephron Disorder And Wilms' Tumor

Wilms Tumor-Dsd Syndrome

Wilms Tumor-Disorder Of Sex Development Syndrome
Behcet Syndrome

Behcet Disease

Behcet'S Syndrome

Behcet'S Disease

Behçet Disease

Bd

Adamantiades-Behcet Disease

Triple Symptom Complex

Behçet'S Disease

Behet'S Syndrome

Bd Syndrome

Behçet Syndrome

Behçet'S Syndrome

Behcet Triple Symptom Complex

Malignant Aphthosis

Old Silk Route Disease

Adamantiades-Behçet Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13797 SRSF6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SRSF6 VGNC VGNC:54735
Mus musculus SRSF6 MGD MGI:1915246
Rattus norvegicus SRSF6 RGD RGD:1359241
Bos taurus SRSF6 VGNC VGNC:57028
Macaca mulatta SRSF6 VGNC VGNC:77821
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