1. Gene
  2. NPM2 - nucleophosmin/nucleoplasmin 2 Gene

NPM2 - nucleophosmin/nucleoplasmin 2 Gene

中文名称:核磷蛋白/核质蛋白 2

种属: Homo sapiens

基因 ID: 10361 | 基因类型: protein coding

关于 NPM2

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,024,134-22,036,897 (from NCBI)

This gene has 14 transcripts (splice variants), 150 orthologues and 2 paralogues. Biased expression in thyroid (RPKM 3.7), brain (RPKM 3.7) and 12 other tissues.

功能概要

预测启用 RNA 结合活性;染色质结合活性;和组蛋白结合活性。参与多个过程,包括囊胚发育;卵母细胞分化;和细胞周期过程的调节。位于染色质和细胞核中。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable RNA binding activity; chromatin binding activity; and histone binding activity. Involved in several processes, including blastocyst development; oocyte differentiation; and regulation of cell cycle process. Located in chromatin and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NPM2 基因产物(12)

mRNA Protein Name
NM_001286680.2 NP_001273609.1 nucleoplasmin-2 isoform 1
NM_001286681.2 NP_001273610.1 nucleoplasmin-2 isoform 2
NM_001413113.1 NP_001400042.1 nucleoplasmin-2 isoform 1
NM_001413114.1 NP_001400043.1 nucleoplasmin-2 isoform 3
NM_001413115.1 NP_001400044.1 nucleoplasmin-2 isoform 4
NM_001413116.1 NP_001400045.1 nucleoplasmin-2 isoform 1
NM_001413117.1 NP_001400046.1 nucleoplasmin-2 isoform 5
NM_001413118.1 NP_001400047.1 nucleoplasmin-2 isoform 5
NM_001413119.1 NP_001400048.1 nucleoplasmin-2 isoform 5
NM_001413120.1 NP_001400049.1 nucleoplasmin-2 isoform 4
NM_001413121.1 NP_001400050.1 nucleoplasmin-2 isoform 2
NM_182795.2 NP_877724.1 nucleoplasmin-2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in blastocyst development IMP
IMP: 通过突变表型推断
12714744 GOA
involved in chromatin remodeling IDA
IDA: 通过直接分析推断
12714744 GOA
involved in oocyte differentiation IEP
IEP: 通过表达模式推断
12714744 GOA
involved in positive regulation of meiotic nuclear division IMP
IMP: 通过突变表型推断
12714744 GOA
involved in regulation of exit from mitosis IMP
IMP: 通过突变表型推断
12714744 GOA
involved in single fertilization IMP
IMP: 通过突变表型推断
12714744 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
12714744 GOA
located in nucleus IDA
IDA: 通过直接分析推断
12714744 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NPM2 蛋白结构

Nucleoplasmin

Nucleoplasmin: Nucleoplasmin/nucleophosmin domain (15 - 165)

  • 0
  • 100
  • 200
  • 214 a.a.
蛋白主名 其他名称

nucleoplasmin-2

NPM2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NPM2 Q86SE8 NPM3 Homo sapiens O75607 31515488
种属内
NPM2 Q86SE8 NPM3 Homo sapiens O75607 25416956
种属内
NPM2 Q86SE8 NPM3 Homo sapiens O75607 33961781
种属内
NPM2 Q86SE8 NPM3 Homo sapiens O75607 25416956
种属内
NPM2 Q86SE8 NPM3 Homo sapiens O75607 28514442
种属内
NPM2 Q86SE8 NPM3 Homo sapiens O75607 25416956
种属内
NPM2 Q86SE8 PLEKHF2 Homo sapiens Q9H8W4 25416956
种属内
NPM2 Q86SE8 SDCBP2 Homo sapiens Q9H190 25416956
种属内
NPM2 Q86SE8 SDCBP2 Homo sapiens Q9H190 31515488
种属内
NPM2 Q86SE8 NPM1 Homo sapiens P06748 25416956
种属内
NPM2 Q86SE8 NPM1 Homo sapiens P06748 33961781
种属内
NPM2 Q86SE8 NPM1 Homo sapiens P06748 25416956
种属内
NPM2 Q86SE8 NPM1 Homo sapiens P06748 31515488
种属内
NPM2 Q86SE8 NPM1 Homo sapiens P06748 25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta NPM2 VGNC VGNC:75384
Felis catus NPM2 VGNC VGNC:107356
Mus musculus NPM2 MGD MGI:1890811
Bos taurus NPM2 VGNC VGNC:32207
Rattus norvegicus NPM2 RGD RGD:727816