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  2. ADAP1 - ArfGAP with dual PH domains 1 Gene

ADAP1 - ArfGAP with dual PH domains 1 Gene

中文名称:具有双 PH 域的 ArfGAP 1

种属: Homo sapiens

同用名: GCS1L; CENTA1; p42IP4

基因 ID: 11033 | 基因类型: protein coding

关于 ADAP1

Cytogenetic location: 7p22.3 Genomic coordinates (GRCh38): 7:897,900-955,407 (from NCBI)

This gene has 19 transcripts (splice variants), 262 orthologues and 28 paralogues. Broad expression in brain (RPKM 18.4), colon (RPKM 17.8) and 18 other tissues.

功能概要

启用 GTPase 激活剂活动。参与 GTPase 活性的调节。位于胞质溶胶中;核;和质膜。 [由基因组资源联盟提供,2022 年 4 月]

Enables GTPase activator activity. Involved in regulation of GTPase activity. Located in cytosol; nucleus; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ADAP1 基因产物(5)

mRNA Protein Name
NM_001284308.2 NP_001271237.2 arf-GAP with dual PH domain-containing protein 1 isoform 2
NM_001284309.2 NP_001271238.2 arf-GAP with dual PH domain-containing protein 1 isoform 3
NM_001284310.2 NP_001271239.2 arf-GAP with dual PH domain-containing protein 1 isoform 3
NM_001284311.2 NP_001271240.2 arf-GAP with dual PH domain-containing protein 1 isoform 4
NM_006869.4 NP_006860.2 arf-GAP with dual PH domain-containing protein 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activator activity IDA
IDA: 通过直接分析推断
10333475 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12893243 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of GTPase activity IMP
IMP: 通过突变表型推断
10333475 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
10333475 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10333475 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
10333475 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ADAP1 蛋白结构

ArfGap

ArfGap: Putative GTPase activating protein for Arf (8 - 119)

PH_11

PH_11: Pleckstrin homology domain (255 - 353)

  • 0
  • 100
  • 200
  • 300
  • 374 a.a.
蛋白主名 其他名称

arf-GAP with dual PH domain-containing protein 1

centaurin-alpha

ADAP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ADAP1 O75689 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra ADAP1 O75689 DVL3 Homo sapiens Q92997
Y2H Array
25416956
Intra ADAP1 O75689 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
Intra ADAP1 O75689 SDCBP2 Homo sapiens Q9H190
Y2H Prey Pooling
25416956
Intra ADAP1 O75689 KIF13B Homo sapiens Q9NQT8
X-Ray Diffraction
21057110
Intra ADAP1 O75689 KIF13B Homo sapiens Q9NQT8
Pull Down
21057110
Intra ADAP1 O75689 KIF13B Homo sapiens Q9NQT8
GMS
21057110
Intra ADAP1 O75689 KIF13B Homo sapiens Q9NQT8
ITC
21057110
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ADAP1 VGNC VGNC:69429
Rattus norvegicus ADAP1 RGD RGD:621418
Canis familiaris ADAP1 VGNC VGNC:37610
Mus musculus ADAP1 MGD MGI:2442201
Bos taurus ADAP1 VGNC VGNC:25633
Felis catus ADAP1 VGNC VGNC:59604