PPP5C - protein phosphatase 5 catalytic subunit Gene

中文名称：蛋白磷酸酶 5 催化亚基

种属: Homo sapiens

同用名: PP5; PPT; PPP5

基因 ID: 5536 | 基因类型: protein coding

关于 PPP5C

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,347,087-46,390,975 (from NCBI)

This gene has 15 transcripts (splice variants), 197 orthologues and 12 paralogues. Ubiquitous expression in heart (RPKM 18.5), brain (RPKM 17.4) and 25 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸磷酸酶，它是蛋白磷酸酶催化亚基家族的成员。该家族中的蛋白质参与由丝氨酸和苏氨酸残基可逆磷酸化调节的途径；其中许多途径都参与细胞生长和分化的调节。该基因的产物已被证明参与响应激素或细胞应激的信号通路，并且该蛋白质水平升高可能与乳腺癌的发展有关。可变剪接导致多个转录本变体。[RefSeq 提供，2011 年 2 月]

This gene encodes a serine/threonine Phosphatase which is a member of the protein Phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to Hormones or cellular stress, and elevated levels of this protein may be associated with breast Cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]

PPP5C 基因产物(2)

mRNA	Protein	Name
NM_001204284.2	NP_001191213.1	serine/threonine-protein phosphatase 5 isoform 2
NM_006247.4	NP_006238.1	serine/threonine-protein phosphatase 5 isoform 1

PPP5C 蛋白结构

TPR_11

TPR_1

PPP5

Metallophos

0
100
200
300
400
499 a.a.

蛋白主名

其他名称

serine/threonine-protein phosphatase 5

PP-T

PPP5C 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PPP5C	P53041	STIP1	Homo sapiens	P31948	Anti Tag CoIP	21360678
种属内	PPP5C	P53041	STIP1	Homo sapiens	P31948	Pull Down	28330616
种属内	PPP5C	P53041	STIP1	Homo sapiens	P31948	Anti Tag CoIP	28330616
种属内	PPP5C	P53041	NOL9	Homo sapiens	Q5SY16	Pull Down	28330616
种属内	PPP5C	P53041	NOL9	Homo sapiens	Q5SY16	Anti Tag CoIP	28330616
种属内	PPP5C	P53041	CDK9	Homo sapiens	P50750	BioID	28330616
种属内	PPP5C	P53041	CDK9	Homo sapiens	P50750	Pull Down	28330616
种属内	PPP5C	P53041	CDK9	Homo sapiens	P50750	Anti Tag CoIP	28330616
种属内	PPP5C	P53041	CRY2	Homo sapiens	Q49AN0	Anti Tag CoIP	16790549
种属内	PPP5C	P53041	AGO3	Homo sapiens	Q9H9G7	Anti Tag CoIP	28330616
种属内	PPP5C	P53041	AGO3	Homo sapiens	Q9H9G7	Pull Down	28330616
种属内	PPP5C	P53041	CDC37	Homo sapiens	Q16543	Pull Down	28330616
种属内	PPP5C	P53041	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	25036637
种属内	PPP5C	P53041	CDC37	Homo sapiens	Q16543	Anti Tag CoIP	21360678
种属内	PPP5C	P53041	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	26496610
种属内	PPP5C	P53041	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	21360678
种属内	PPP5C	P53041	HSP90AA1	Homo sapiens	P07900	BioID	28330616
种属内	PPP5C	P53041	HSP90AA1	Homo sapiens	P07900	Pull Down	28330616
种属内	PPP5C	P53041	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	27880917
种属内	PPP5C	P53041	PPP2R1A	Homo sapiens	P30153	CoIP	11504734
种属内	PPP5C	P53041	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	27880917
种属内	PPP5C	P53041	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	25036637
种属内	PPP5C	P53041	HSP90AB1	Homo sapiens	P08238	BioID	28330616
种属内	PPP5C	P53041	HSP90AB1	Homo sapiens	P08238	NMR	16531226
种属内	PPP5C	P53041	HSP90AB1	Homo sapiens	P08238	Pull Down	28330616
种属内	PPP5C	P53041	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	26496610
种属内	PPP5C	P53041	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	21360678
种属内	PPP5C	P53041	AGO1	Homo sapiens	Q9UL18	Pull Down	28330616
种属内	PPP5C	P53041	AGO1	Homo sapiens	Q9UL18	Anti Tag CoIP	28330616
种属内	PPP5C	P53041	PTGES3	Homo sapiens	Q15185	Anti Tag CoIP	25036637
种属内	PPP5C	P53041	PTGES3	Homo sapiens	Q15185	Pull Down	28330616
种属内	PPP5C	P53041	ESR1	Homo sapiens	P03372	Pull Down	14764652
种属内	PPP5C	P53041	ESR1	Homo sapiens	P03372	Anti Bait CoIP	14764652
种属内	PPP5C	P53041	ESR2	Homo sapiens	Q92731	Y2H	14764652

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Microcephaly, Seizures, And Developmental Delay

MCSZ	Developmental And Epileptic Encephalopathy 10
Epileptic Encephalopathy, Early Infantile, 10	Eiee10
Dee10	Early Infantile Epileptic Encephalopathy 10

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11032	PPP5C Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	PPP5C	VGNC	VGNC:33272
Canis familiaris	PPP5C	VGNC	VGNC:49945
Rattus norvegicus	PPP5C	RGD	RGD:68415
Macaca mulatta	PPP5C	VGNC	VGNC:76385
Mus musculus	PPP5C	MGD	MGI:102666
Felis catus	PPP5C	VGNC	VGNC:69024

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PPP5C - protein phosphatase 5 catalytic subunit Gene

关于 PPP5C

功能概要

PPP5C 基因产物(2)

PPP5C 蛋白结构

PPP5C 蛋白互作信息

关联疾病

直系同源

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PPP5C - protein phosphatase 5 catalytic subunit Gene

关于 PPP5C

功能概要

PPP5C 基因产物(2)

PPP5C 蛋白结构

PPP5C 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z