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  2. PPP5C - protein phosphatase 5 catalytic subunit Gene

PPP5C - protein phosphatase 5 catalytic subunit Gene

中文名称:蛋白磷酸酶 5 催化亚基

种属: Homo sapiens

同用名: PP5; PPT; PPP5

基因 ID: 5536 | 基因类型: protein coding

关于 PPP5C

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,347,087-46,390,975 (from NCBI)

This gene has 15 transcripts (splice variants), 197 orthologues and 12 paralogues. Ubiquitous expression in heart (RPKM 18.5), brain (RPKM 17.4) and 25 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸磷酸酶,它是蛋白磷酸酶催化亚基家族的成员。该家族中的蛋白质参与由丝氨酸和苏氨酸残基可逆磷酸化调节的途径;其中许多途径都参与细胞生长和分化的调节。该基因的产物已被证明参与响应激素或细胞应激的信号通路,并且该蛋白质水平升高可能与乳腺癌的发展有关。可变剪接导致多个转录本变体。[RefSeq 提供,2011 年 2 月]

This gene encodes a serine/threonine Phosphatase which is a member of the protein Phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these pathways are involved in the regulation of cell growth and differentiation. The product of this gene has been shown to participate in signaling pathways in response to Hormones or cellular stress, and elevated levels of this protein may be associated with breast Cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]

PPP5C 基因产物(2)

mRNA Protein Name
NM_001204284.2 NP_001191213.1 serine/threonine-protein phosphatase 5 isoform 2
NM_006247.4 NP_006238.1 serine/threonine-protein phosphatase 5 isoform 1

PPP5C 蛋白结构

TPR_11

TPR_11: TPR repeat (27 - 93)

TPR_1

TPR_1: Tetratricopeptide repeat (97 - 129)

PPP5

PPP5: PPP5 TPR repeat region (135 - 228)

Metallophos

Metallophos: Calcineurin-like phosphoesterase (236 - 430)

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  • 499 a.a.
蛋白主名 其他名称

serine/threonine-protein phosphatase 5

PP-T

关联疾病

疾病名称 别名
Microcephaly, Seizures, And Developmental Delay

MCSZ

Developmental And Epileptic Encephalopathy 10

Epileptic Encephalopathy, Early Infantile, 10

Eiee10

Dee10

Early Infantile Epileptic Encephalopathy 10

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus PPP5C VGNC VGNC:33272
Canis familiaris PPP5C VGNC VGNC:49945
Rattus norvegicus PPP5C RGD RGD:68415
Macaca mulatta PPP5C VGNC VGNC:76385
Mus musculus PPP5C MGD MGI:102666
Felis catus PPP5C VGNC VGNC:69024