2. Gene
  3. PDE9A - phosphodiesterase 9A Gene

PDE9A - phosphodiesterase 9A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷酸二酯酶 9A

种属: Homo sapiens

同用名: HSPDE9A2

基因 ID: 5152 | 基因类型: protein coding

关于 PDE9A

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:42,653,621-42,775,509 (from NCBI)

This gene has 28 transcripts (splice variants), 192 orthologues and 20 paralogues. Broad expression in colon (RPKM 12.5), prostate (RPKM 9.8) and 17 other tissues.

功能概要

由该基因编码的蛋白质催化 cAMP 和 cGMP 水解成相应的单磷酸盐。编码的蛋白质通过调节这些环核苷酸的细胞内浓度在信号转导中发挥作用。已发现该基因的多个转录变体编码几种不同的亚型。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PDE9A 基因产物(24)

mRNA Protein Name
NM_001001576.2 NP_001001576.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform j
XM_011529598.3 XP_011527900.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1
NM_001001584.3 NP_001001584.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g
NM_001001583.2 NP_001001583.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform o
NM_001001568.2 NP_001001568.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform c
NM_001001573.2 NP_001001573.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g
NM_001001572.2 NP_001001572.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g
NM_001001567.2 NP_001001567.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform b
NM_001001569.2 NP_001001569.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform d
XM_011529600.3 XP_011527902.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2
NM_001001581.2 NP_001001581.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform m
NM_001001575.2 NP_001001575.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform i
NM_001001578.2 NP_001001578.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform l
NM_001001585.2 NP_001001585.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g
XM_017028366.2 XP_016883855.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X3
NM_002606.3 NP_002597.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform a
NM_001001579.2 NP_001001579.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g
NM_001001571.2 NP_001001571.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform f
NM_001001582.2 NP_001001582.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform n
NM_001001577.2 NP_001001577.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform k
NM_001001570.2 NP_001001570.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform e
NM_001315533.2 NP_001302462.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform p
NM_001001574.2 NP_001001574.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform h
NM_001001580.2 NP_001001580.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform j
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
IDA: 通过直接分析推断
9624146 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
26871637 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cGMP catabolic process IDA
IDA: 通过直接分析推断
25799991 GOA
involved in cGMP metabolic process IDA
IDA: 通过直接分析推断
9624146 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in sarcolemma IDA
IDA: 通过直接分析推断
25799991 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDE9A 蛋白结构

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (311 - 534)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 593 a.a.
蛋白主名 其他名称

high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

CGMP-specific 3',5'-cyclic phosphodiesterase type 9

phosphodiesterase PDE9A21

PDE9A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PDE9A O76083 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
25416956
种属内
PDE9A O76083 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
种属内
PDE9A O76083 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
种属内
PDE9A O76083 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Prey Pooling
25416956
种属内
PDE9A O76083 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Array
25416956
种属内
PDE9A O76083 LINC02913 Homo sapiens Q8NAJ2
Validated Y2H
25416956
种属内
PDE9A O76083 LINC02913 Homo sapiens Q8NAJ2
Y2H Array
25416956
种属内
PDE9A O76083 LINC02913 Homo sapiens Q8NAJ2
Y2H Prey Pooling
25416956
种属内
PDE9A O76083 PHYHIPL Homo sapiens Q96FC7-2
Y2H Array
25416956
种属内
PDE9A O76083 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Prey Pooling
25416956
种属内
PDE9A O76083 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
25416956
种属内
PDE9A O76083 LAGE3 Homo sapiens Q14657
Validated Y2H
25416956
种属内
PDE9A O76083 PDE9A Homo sapiens O76083-2
Y2H Array
26871637
种属内
PDE9A O76083 PDE9A Homo sapiens O76083-2
Y2H Prey Pooling
26871637
种属内
PDE9A O76083 PDE9A Homo sapiens O76083-2
Validated Y2H
26871637
种属内
PDE9A O76083 CRY2 Homo sapiens Q49AN0
Validated Y2H
25416956
种属内
PDE9A O76083 CLK1 Homo sapiens P49759
Y2H Array
25416956
种属内
PDE9A O76083 UTP23 Homo sapiens Q9BRU9
Y2H Array
25416956
种属内
PDE9A O76083 SULT1E1 Homo sapiens P49888
Y2H Array
25416956
种属内
PDE9A O76083 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
25416956
种属内
PDE9A O76083 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
25416956
种属内
PDE9A O76083 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
25416956
种属内
PDE9A O76083 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
29892012
种属内
PDE9A O76083 LMO2 Homo sapiens P25791
Y2H Prey Pooling
25416956
种属内
PDE9A O76083 LMO2 Homo sapiens P25791
Validated Y2H
25416956
种属内
PDE9A O76083 LMO2 Homo sapiens P25791
Y2H Array
25416956
种属内
PDE9A O76083 TRIM32 Homo sapiens Q13049
Y2H Pooling
16189514
种属内
PDE9A O76083 TRIM32 Homo sapiens Q13049
Y2H Array
31515488
种属内
PDE9A O76083 TRIM32 Homo sapiens Q13049
Y2H Prey Pooling
25416956
种属内
PDE9A O76083 TRIM32 Homo sapiens Q13049
Y2H Prey Pooling
26871637
种属内
PDE9A O76083 TRIM32 Homo sapiens Q13049
Y2H Array
19060904
种属内
PDE9A O76083 TRIM32 Homo sapiens Q13049
Validated Y2H
26871637
种属内
PDE9A O76083 TRIM32 Homo sapiens Q13049
Y2H Array
25416956
种属内
PDE9A O76083 TRIM32 Homo sapiens Q13049
Y2H Array
26871637
种属内
PDE9A O76083 TRIM32 Homo sapiens Q13049
Y2H Pooling
19060904
种属内
PDE9A O76083 BAG3 Homo sapiens O95817
Y2H Array
25416956
种属内
PDE9A O76083 BAG3 Homo sapiens O95817
Y2H Prey Pooling
25416956
种属内
PDE9A O76083 BAG3 Homo sapiens O95817
Validated Y2H
25416956
种属内
PDE9A O76083 ZFAB Homo sapiens Q9Y260
Validated Y2H
25416956
种属内
PDE9A O76083 ZFAB Homo sapiens Q9Y260
Y2H Array
25416956
种属内
PDE9A O76083 ZFAB Homo sapiens Q9Y260
Y2H Prey Pooling
25416956
种属内
PDE9A O76083 NAA38 Homo sapiens Q9BRA0
Validated Y2H
25416956
种属内
PDE9A O76083 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
31515488
种属内
PDE9A O76083 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PDE9A 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75962 PDE9A Protein, Human (sf9, His-GST) O76083-2 (M1-A533) ≥95%
HY-P75963 PDE9A Protein, Human (His) O76083-2 (P181-K506) ≥95%

关联疾病

疾病名称 别名
Cecum Adenocarcinoma

Cecal Adenocarcinoma

Adenocarcinoma Of Cecum
Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Congenital Anomaly Of Heart

Heart Defect

Heart Malformation

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure
Transient Global Amnesia

Amnesia, Transient Global
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-15441 Edelinontrine Inhibitor 99.85% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12788 PF-04449613 Inhibitor 99.83% 否
HY-104028 BAY 73-6691 Inhibitor 99.84% 否
HY-126137 PDE9-IN-1 Inhibitor 99.70% 否
HY-152106 BAY-7081 Inhibitor 98.00% 否
HY-12788A (S)-PF-04449613 Inhibitor 99.85% 否
HY-104028B (S)-BAY 73-6691 Control 99.51% 否
HY-RS10246 PDE9A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10247 Pde9a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10248 Pde9a Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PDE9A VGNC VGNC:75925
Bos taurus PDE9A VGNC VGNC:32688
Rattus norvegicus PDE9A RGD RGD:621035
Mus musculus PDE9A MGD MGI:1277179
Felis catus PDE9A VGNC VGNC:68767
Canis familiaris PDE9A VGNC VGNC:44367
Others PDE9A NCBI
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