PDE9A 蛋白, Human (His)

PDE9A is a phosphodiesterase that uniquely hydrolyzes second messengers with unparalleled specificity, particularly in the regulation of natriuretic peptide-dependent signaling in the heart, which is critical for the control of cardiac hypertrophy. Its specificity rules out effects on nitric oxide-dependent signaling in the heart. PDE9A Protein, Human (His) is the recombinant human-derived PDE9A protein, expressed by E. coli , with N-His labeled tag. The total length of PDE9A Protein, Human (His) is 326 a.a., with molecular weight of ~37 kDa.

PDE9A 是一种磷酸二酯酶，与环核苷酸磷酸二酯酶家族的其他成员相比，通过以最高的亲和力和选择性水解第二信使，表现出显着的特异性。其独特的作用在调节心脏中的利尿钠肽依赖性信号传导方面很明显，它是心肌细胞和肌肉中心脏肥大的关键调节剂。值得注意的是，PDE9A 不影响心脏中一氧化氮依赖性信号传导，突出了其对利尿钠肽依赖性途径的特异性。需要进一步研究以确定其在水解钠尿肽依赖性顺式中的作用是否是心脏独有的，或者是否代表了该蛋白质的更广泛特征。此外，在大脑中，PDE9A 有助于学习和长期记忆等认知功能，强调其在不同组织中的不同生理作用。

Human

E. coli

N-His

O76083-2 (P181-K506)

5152  [NCBI]

Approximately 37 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.