2. Anti-infection Apoptosis
  3. Antibiotic Bacterial Parasite Apoptosis
  4. Metronidazole hydrochloride

Metronidazole hydrochloride  (Synonyms: 盐酸甲硝唑; SC 326421)

目录号: HY-B0318A
产品使用指南

摩尔计算器

Metronidazole hydrochloride (SC 326421) 是一种具有口服活性的硝基咪唑类抗生素，能用于研究厌氧微生物的感染。Metronidazole hydrochloride 能够穿过血脑屏障，长期使用会导致炎症和骨骼肌收缩。

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Metronidazole hydrochloride Chemical Structure

Metronidazole hydrochloride Chemical Structure

CAS No. : 69198-10-3

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Metronidazole hydrochloride 的其他形式现货产品:

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Metronidazole hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Metronidazole hydrochloride (SC 326421) is an orally active nitroimidazole antibiotic, can be used to research anaerobic infections. Metronidazole hydrochloride can cross blood brain barrier and results inflammation and skeletal muscle contraction under long-term application[1][2][3][4].

体外研究
(In Vitro)

Metronidazole hydrochloride acts on anaerobic microorganism following: passage through the cell membrane; (b) reductive action; (c) interaction with intracellular targets; (d) release of inactive end products, exerts function with toxic nitro and nitroso derivatives[1].
Metronidazole hydrochloride displays inhibitory activity towards anaerobic protozoa Trichomonas vaginalis, Entamoeba histolytica, Giardia lamblia, and Balantidium coli[1].
Metronidazole hydrochloride (4-8 μg/mL) inhibits anaerobic bacteria and shows good bactericidal activity[1].
Metronidazole hydrochloride (0.1 μg/mL-0.01 mg/mL; 12-96 h) induces granular formation and triggers apoptosis in Blastocystis sp[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Metronidazole hydrochloride 相关抗体:

Apoptosis Analysis[2]

Cell Line: Blastocystis sp. Cells
Concentration: 0.1 μg/mL-0.01 mg/mL
Incubation Time: 12, 24, 48, 60, 72, 84, 96 hours
Result: Decreased cell diameter, as a hallmark of an apoptotic cell, and resulted cell shrinkage.
体内研究
(In Vivo)

Metronidazole hydrochloride (135 mg/kg/d; p.o.; 28 d) can cross the blood brain barrier, and exhibits neurotoxicity under long term administration in rats[3].
Metronidazole hydrochloride (1 g/L; p.o.; 4 weeks) results skeletal muscle atrophy and changes the expression of genes involved in the muscle peripheral circadian rhythm machinery and metabolic regulation[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley (SD) rats (200-220 g)[3]
Dosage: 135 mg/kg
Administration: Oral gavage; once daily; 28 days
Result: Caused inflammatory markers increasing, including iNOS, eNOS, Bax and caspase 3 protein expressions increasing and caused oxidative stress damage in brain tissue, with MDA content rising.
Animal Model: SPF C57Bl/6J mice (6-7 months old)[4]
Dosage: 1 g/L (full dose)
Administration: Oral gavage; provided with drinking water for 4 weeks, changed twice weekly
Result: Resulted the muscle core clock and effector genes Cry2, Ror-β, E4BP4, PP ARγ and adiponectin expression increasing.
Decreased hind limb muscle weight and resulted in smaller fibers in the tibialis anterior muscle.
Clinical Trial
分子量

207.61

Formula

C6H10ClN3O3
CAS 号
中文名称

盐酸甲硝唑
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Metronidazole hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Metronidazole69198-10-3SC 326421盐酸甲硝唑SC326421SC-326421AntibioticBacterialParasiteApoptosisanaerobic infectionanaerobic protozoaTrichomonas vaginalisEntamoeba histolyticaGiardia lambliaBalantidium coli.BaxBcl2iNOSeNOScaspase-3Cry2Ror-βE4BP4. PP ARγadiponectinInhibitorinhibitorinhibit

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