2. Gene
  3. HSPA12B - heat shock protein family A (Hsp70) member 12B Gene

HSPA12B - heat shock protein family A (Hsp70) member 12B Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：热休克蛋白家族 A (Hsp70) 成员 12B

种属: Homo sapiens

同用名: C20orf60

基因 ID: 116835 | 基因类型: protein coding

关于 HSPA12B

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,732,685-3,753,111 (from NCBI)

This gene has 2 transcripts (splice variants), 193 orthologues and 4 paralogues. Broad expression in fat (RPKM 15.5), spleen (RPKM 11.6) and 19 other tissues.

功能概要

该基因编码的蛋白质包含非典型热休克蛋白 70 (HSP70) ATPase 结构域，因此是哺乳动物 HSP70 家族的远亲成员。该基因可能与动脉粥样硬化的易感性有关。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2015 年 12 月]

The protein encoded by this gene contains an atypical heat shock protein 70 (HSP70) ATPase domain and is therefore a distant member of the mammalian HSP70 family. This gene may be involved in susceptibility to atherosclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

HSPA12B 基因产物(3)

mRNA Protein Name
NM_001197327.2 NP_001184256.1 heat shock 70 kDa protein 12B isoform 2
NM_001318322.2 NP_001305251.1 heat shock 70 kDa protein 12B isoform 3
NM_052970.5 NP_443202.3 heat shock 70 kDa protein 12B isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

heat shock 70 kDa protein 12B

HSPA12B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra HSPA12B Q96MM6 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra HSPA12B Q96MM6 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra HSPA12B Q96MM6 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra HSPA12B Q96MM6 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra HSPA12B Q96MM6 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra HSPA12B Q96MM6 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra HSPA12B Q96MM6 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra HSPA12B Q96MM6 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra HSPA12B Q96MM6 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra HSPA12B Q96MM6 HSPA12A Homo sapiens O43301
Y2H Array
32296183
Intra HSPA12B Q96MM6 HSPA12A Homo sapiens O43301
Y2H Prey Pooling
32296183
Intra HSPA12B Q96MM6 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra HSPA12B Q96MM6 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra HSPA12B Q96MM6 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra HSPA12B Q96MM6 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra HSPA12B Q96MM6 EFEMP2 Homo sapiens O95967
Y2H Prey Pooling
32296183
Intra HSPA12B Q96MM6 EFEMP2 Homo sapiens O95967
Y2H Array
32296183
Intra HSPA12B Q96MM6 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra HSPA12B Q96MM6 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra HSPA12B Q96MM6 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra HSPA12B Q96MM6 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra HSPA12B Q96MM6 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06421 HSPA12B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta HSPA12B VGNC VGNC:84531
Felis catus HSPA12B VGNC VGNC:80114
Mus musculus HSPA12B MGD MGI:1919880
Canis familiaris HSPA12B VGNC VGNC:53543
Rattus norvegicus HSPA12B RGD RGD:1312004
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