2. Apoptosis
  3. DAPK
  4. TNIK-IN-3

TNIK-IN-3 (化合物 21k) 是一种有效，选择性和具有口服活性的 TNIK 抑制剂，IC50 值为 0.026 μM。TNIK-IN-3 还可以抑制 Flt4 (IC50=0.030 μM)，Flt1 (IC50=0.191 μM) 和 DRAK1 (IC50=0.411 μM)。TNIK-IN-3 可用于结直肠癌的研究。

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TNIK-IN-3 Chemical Structure

TNIK-IN-3 Chemical Structure

CAS No. : 2754265-25-1

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥3630
In-stock
1 mg ￥1300
In-stock
5 mg ￥3300
In-stock
10 mg ￥5200
In-stock
25 mg 现货 询价
50 mg   询价  
100 mg   询价  

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Customer Review

TNIK-IN-3 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TNIK-IN-3 is a potent, selective and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK), with an IC50 of 0.026 μM. TNIK-IN-3 could also inhibit Flt4 (IC50=0.030 μM), Flt1 (IC50=0.191 μM) and DRAK1 (IC50=0.411 μM). TNIK-IN-3 can be used for the research of colorectal cancer[1].

IC50 & Target

IC50: 0.026 μM (TNIK)[1], 0.030 μM (Flt4)[1], 0.191 μM (Flt1)[1], 0.411 μM (DRAK1)[1]
体外研究
(In Vitro)

TNIK-IN-3 (compound 21k) inhibits Aurora-A, GCK, and MLK3 with IC50s of 0.517 μM, 3.657 μM, and 4.552 μM, respectively[1].
TNIK-IN-3 (0.1-100 μM; 3 days) inhibits the viability of HCT116 and DLD-1 cells, with IC50s of 4.26 μM and 8.00 μM, respectively[1].
TNIK-IN-3 (2.5-40 μM; 10 days) dose-dependently inhibits the colony formation of HCT116 and DLD-1 cells[1].
TNIK-IN-3 (5-20 μM; 48 h) inhibits the migration of HCT116 and DLD-1 cells[1].
TNIK-IN-3 (5-40 μM; 48 h) dose-dependently inhibits the expression ofLRP5 and LRP6 proteins, Wnt target genes AXIN2 and c-Myc in HCT116 cells[1].
TNIK-IN-3 (5-20 μM; 48 h) significantly suppresses the phosphorylation of JNK1/2 in Hela cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TNIK-IN-3 相关抗体:

Cell Viability Assay[1]

Cell Line: HCT116 and DLD-1 cells
Concentration: 0.1-100 μM
Incubation Time: 3 days
Result: Inhibited cell viability in a dose-dependent manner.

Cell Viability Assay[1]

Cell Line: HCT116 cells
Concentration: 5, 10, 20, 40 μM
Incubation Time: 48 hours
Result: Inhibited the expression of Wnt target genes AXIN2 and c-Myc, LRP5 and LRP6 proteins.
体内研究
(In Vivo)

TNIK-IN-3 (compound 21k) (100-150 mg/kg; p.o. twice daily for 18 days) inhibits tumor growth in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old female NOD-SCID mice were injected with HCT116 cells[1]
Dosage: 100, 150 mg/kg
Administration: P.o. twice daily for 18 days
Result: Significantly inhibited tumor growth at a dose of 150 mg/kg.
No obvious weight loss and no other side effects were observed.
分子量

387.41

Formula

C23H18FN3O2
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 83.33 mg/mL (215.10 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5812 mL 12.9062 mL 25.8124 mL
5 mM 0.5162 mL 2.5812 mL 5.1625 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.88%

COA (263 KB) HNMR (263 KB) LCMS (253 KB)

产品使用指南 (1538 KB)
参考文献

TNIK-IN-3 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5812 mL 12.9062 mL 25.8124 mL 64.5311 mL
5 mM 0.5162 mL 2.5812 mL 5.1625 mL 12.9062 mL
10 mM 0.2581 mL 1.2906 mL 2.5812 mL 6.4531 mL
15 mM 0.1721 mL 0.8604 mL 1.7208 mL 4.3021 mL
20 mM 0.1291 mL 0.6453 mL 1.2906 mL 3.2266 mL
25 mM 0.1032 mL 0.5162 mL 1.0325 mL 2.5812 mL
30 mM 0.0860 mL 0.4302 mL 0.8604 mL 2.1510 mL
40 mM 0.0645 mL 0.3227 mL 0.6453 mL 1.6133 mL
50 mM 0.0516 mL 0.2581 mL 0.5162 mL 1.2906 mL
60 mM 0.0430 mL 0.2151 mL 0.4302 mL 1.0755 mL
80 mM 0.0323 mL 0.1613 mL 0.3227 mL 0.8066 mL
100 mM 0.0258 mL 0.1291 mL 0.2581 mL 0.6453 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNIK-IN-32754265-25-1DAPKDeath associated protein kinaseTNIKFlt4Flt1DRAK1colorectalcancerInhibitorinhibitorinhibit

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目录号：
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