2. Gene
  3. PALS1 - protein associated with LIN7 1, MAGUK p55 family member Gene

PALS1 - protein associated with LIN7 1, MAGUK p55 family member Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：与 LIN7 1 相关的蛋白质，MAGUK p55 家族成员

种属: Homo sapiens

同用名: MPP5

基因 ID: 64398 | 基因类型: protein coding

关于 PALS1

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:67,241,435-67,336,061 (from NCBI)

This gene has 13 transcripts (splice variants), 278 orthologues, 7 paralogues and is associated with 1 phenotype. Ubiquitous expression in kidney (RPKM 15.8), thyroid (RPKM 14.7) and 25 other tissues.

功能概要

该基因编码膜相关鸟苷酸激酶 (MAGUK) 基因超家族的 p55 样亚家族成员。编码的蛋白质参与分化细胞的极化，已被证明可以调节髓鞘形成的雪旺细胞 (PMID：20237282) ，并且是视网膜中 Crumbs 复合体的成分之一。表达较低水平同源蛋白的小鼠会出现视网膜退化和视力受损 (PMID: 22114289) 。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2012 年 2 月]

This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

PALS1 基因产物(2)

mRNA Protein Name
NM_001256550.2 NP_001243479.1 protein PALS1 isoform 2
NM_022474.4 NP_071919.2 protein PALS1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
15914641 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11927608 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
17332497 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in morphogenesis of an epithelial sheet IMP
IMP: 通过突变表型推断
23201090 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in adherens junction IDA
IDA: 通过直接分析推断
15914641 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
15914641 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PALS1 蛋白结构

L27_N

L27_N: L27_N (123 - 170)

L27

L27: L27 domain (201 - 231)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (258 - 331)

SH3_2

SH3_2: Variant SH3 domain (349 - 411)

Guanylate_kin

Guanylate_kin: Guanylate kinase (479 - 661)

  • 0
  • 200
  • 400
  • 600
  • 675 a.a.
蛋白主名 其他名称

protein PALS1

MAGUK p55 subfamily member 5

PALS1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PALS1 Q8N3R9 FTCD Homo sapiens O95954
Y2H Array
32296183
种属内
PALS1 Q8N3R9 FTCD Homo sapiens O95954
Y2H Prey Pooling
32296183
种属内
PALS1 Q8N3R9 EPB41L5 Homo sapiens Q9HCM4
Y2H
17920587
种属内
PALS1 Q8N3R9 EPB41L5 Homo sapiens Q9HCM4
Pull Down
17920587
种属内
PALS1 Q8N3R9 EPB41L5 Homo sapiens Q9HCM4
Anti Bait CoIP
17920587
种属内
PALS1 Q8N3R9 CRB1 Homo sapiens P82279
SPR
33758649
种属内
PALS1 Q8N3R9 GPRASP3 Homo sapiens Q6PI77
Y2H Prey Pooling
32296183
种属内
PALS1 Q8N3R9 GPRASP3 Homo sapiens Q6PI77
Y2H Array
32296183
种属内
PALS1 Q8N3R9 LIN7C Homo sapiens Q9NUP9
Y2H Prey Pooling
32296183
种属内
PALS1 Q8N3R9 LIN7C Homo sapiens Q9NUP9
Anti Tag CoIP
24366813
种属内
PALS1 Q8N3R9 LIN7C Homo sapiens Q9NUP9
Anti Tag CoIP
33961781
种属内
PALS1 Q8N3R9 LIN7C Homo sapiens Q9NUP9
Validated Y2H
32296183
种属内
PALS1 Q8N3R9 LIN7C Homo sapiens Q9NUP9
Y2H Array
32296183
种属内
PALS1 Q8N3R9 DLGAP4 Homo sapiens Q9Y2H0-1
Y2H Array
32296183
种属内
PALS1 Q8N3R9 DLGAP4 Homo sapiens Q9Y2H0-1
Validated Y2H
32296183
种属内
PALS1 Q8N3R9 DLGAP4 Homo sapiens Q9Y2H0-1
Y2H Prey Pooling
32296183
种属内
PALS1 Q8N3R9 SRGAP2B Homo sapiens A0A286YEY3
Y2H Prey Pooling
32296183
种属内
PALS1 Q8N3R9 SRGAP2B Homo sapiens A0A286YEY3
Y2H Array
32296183
种属内
PALS1 Q8N3R9 SNTG2 Homo sapiens Q9NY99-2
Y2H Prey Pooling
32296183
种属内
PALS1 Q8N3R9 SNTG2 Homo sapiens Q9NY99-2
Validated Y2H
32296183
种属内
PALS1 Q8N3R9 SNTG2 Homo sapiens Q9NY99-2
Y2H Array
32296183
种属内
PALS1 Q8N3R9 MPP4 Homo sapiens Q96JB8
Pull Down
15914641
种属内
PALS1 Q8N3R9 MPP4 Homo sapiens Q96JB8
Y2H
15914641
种属内
PALS1 Q8N3R9 MPP4 Homo sapiens Q96JB8
Anti Bait CoIP
15914641
种属内
PALS1 Q8N3R9 MPP4 Homo sapiens Q96JB8
Anti Tag CoIP
15914641
种属内
PALS1 Q8N3R9 LIN7A Homo sapiens O14910
Anti Tag CoIP
33961781
种属间
PALS1 Q8N3R9 E SARS-CoV-2 P0DTC4
MST
34103506
种属内
PALS1 Q8N3R9 AMOT Homo sapiens Q4VCS5
Anti Tag CoIP
24366813
种属间
PALS1 Q8N3R9 E SARS-CoV-2 P0DTC4
3D-EM
34103506
种属间
PALS1 Q8N3R9 E SARS-CoV-2 P0DTC4
2D-IR
32822073
种属内
PALS1 Q8N3R9 LIN7A Homo sapiens O14910
Validated Y2H
25416956
种属内
PALS1 Q8N3R9 LIN7A Homo sapiens O14910
Y2H Prey Pooling
32296183
种属内
PALS1 Q8N3R9 LIN7A Homo sapiens O14910
Anti Tag CoIP
24366813
种属间
PALS1 Q8N3R9 E SARS-CoV-2 P0DTC4
FRET
32822073
种属内
PALS1 Q8N3R9 AMOT Homo sapiens Q4VCS5
Anti Tag CoIP
33961781
种属内
PALS1 Q8N3R9 LIN7A Homo sapiens O14910
Y2H Array
25416956
种属间
PALS1 Q8N3R9 E SARS-CoV-2 P0DTC4
SPR
33758649
种属内
PALS1 Q8N3R9 LIN7A Homo sapiens O14910
Y2H Array
32296183
种属内
PALS1 Q8N3R9 AMOT Homo sapiens Q4VCS5
Anti Tag CoIP
21481793
种属间
PALS1 Q8N3R9 E Human SARS coronavirus P59637
SPR
33758649
种属间
PALS1 Q8N3R9 E Human SARS coronavirus P59637
2D-IR
32822073
种属间
PALS1 Q8N3R9 E Human SARS coronavirus P59637
FRET
32822073
种属内
PALS1 Q8N3R9 GSN Homo sapiens P06396
Validated Y2H
32814053
种属内
PALS1 Q8N3R9 GSN Homo sapiens P06396
Y2H Pooling
32814053
种属内
PALS1 Q8N3R9 GSN Homo sapiens P06396
Y2H Array
32814053
种属内
PALS1 Q8N3R9 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
种属内
PALS1 Q8N3R9 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
种属内
PALS1 Q8N3R9 TTR Homo sapiens P02766
Validated Y2H
32814053
种属内
PALS1 Q8N3R9 TTR Homo sapiens P02766
Y2H Array
32814053
种属内
PALS1 Q8N3R9 TTR Homo sapiens P02766
Y2H Pooling
32814053
种属内
PALS1 Q8N3R9 PATJ Homo sapiens Q8NI35
Anti Tag CoIP
33961781
种属内
PALS1 Q8N3R9 PATJ Homo sapiens Q8NI35
Anti Tag CoIP
24366813
种属内
PALS1 Q8N3R9 PATJ Homo sapiens Q8NI35
Anti Tag CoIP
21481793
种属内
PALS1 Q8N3R9 LIN7B Homo sapiens Q9HAP6
Y2H Prey Pooling
32296183
种属内
PALS1 Q8N3R9 LIN7B Homo sapiens Q9HAP6
Validated Y2H
32296183
种属内
PALS1 Q8N3R9 LIN7B Homo sapiens Q9HAP6
Y2H Array
32296183
种属内
PALS1 Q8N3R9 LIN7B Homo sapiens Q9HAP6
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Arachnoid Cysts, Intracranial

Arachnoid Cyst

Arachnoid Cysts

Intracranial Arachnoid Cysts

Arachnoid Brain Cyst

Arachnoid Cerebral Cyst

Intracranium Cyst Nos
Anxiety

Anxiety Disorder

Anxiety Disorders

Anxiety State

Anxieties

Anxiety Neurosis
Cerebral Palsy

Infantile Cerebral Palsy

Mixed Cerebral Palsy

Palsy Cerebral

Palsy, Cerebral

Cerebral Palsy, Mixed
Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder
Retinitis Pigmentosa 12

RP12

Retinitis Pigmentosa With Or Without Paraarteriolar Preservation Of Retinal Pigment Epithelium

Rp With Or Without Preserved Paraarteriole Retinal Pigment Epithelium

Rp With Or Without Pprpe

Retinitis Pigmentosa-12
Retinal Degeneration

Degeneration Of Retina
Intraorbital Meningioma
Endometrial Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Endometrium

Adenosquamous Carcinoma Of The Endometrium

Endometrial Adenosquamous Cancer

Endometrial Adenosquamous Cell Carcinoma
Nephronophthisis 7

NPHP7

Nephronophthisis, Type 7
Leber Congenital Amaurosis 8

LCA8

Leber Congenital Amaurosis, Type 8
Central Sleep Apnea

Central Sleep Apnea Syndrome

Sleep Apnea, Central

Primary Central Sleep Apnea

Central Sleep Apnea, Primary

Central Sleep Apnoea Syndrome

Csa - [Central Sleep Apnoea]

Csas - [Central Sleep Apnoea Syndrome]

Central Sleep Apnoea Due To Substances Including Medications
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Late-Onset Retinal Degeneration

LORD

Retinal Degeneration, Late-Onset, Autosomal Dominant

Autosomal Dominant Late-Onset Retinal Degeneration

Pigmentary Retinopathy

Retinal Degeneration, Late-Onset

Retinitis Pigmentosa
Meckel Syndrome, Type 1

Meckel-Gruber Syndrome

Meckel Syndrome

Dysencephalia Splanchnocystica

Meckel Syndrome 1

MKS1

Mks

Gruber Syndrome

Meckel-Gruber Syndrome, Type 1

Mes

Dysencephalia Splachnocystica

Meckel Gruber Syndrome

Meckel Syndrome Type 1
Leber Plus Disease

Leber Congenital Amaurosis

Lca

Leber'S Amaurosis

Leber'S Disease

Amaurosis Congenita Of Leber

Amaurosis Congenita Of Leber, Type 1

Lhon Plus Disease

Congenital Absence Of The Rods And Cones

Congenital Retinal Blindness

Crb

Congenital Amaurosis Of Retinal Origin

Leber'S Congenital Amaurosis

Leber Congenital Amaurosis 1

Leber'S Congenital Tapetoretinal Degeneration

Leber'S Congenital Tapetoretinal Dysplasia

Lca1

Leber Congenital Amaurosis Type 1

Retinal Blindness, Congenital

Amaurosis, Leber Congenital

Dysgenesis Neuroepithelialis Retinae

Hereditary Epithelial Dysplasia Of Retina

Hereditary Retinal Aplasia

Heredoretinopathia Congenitalis

Leber Abiotrophy

Leber Congenital Tapetoretinal Degeneration

Lebers Congenital Amaurosis

Optic Atrophy, Hereditary, Leber
Fundus Dystrophy

Retinal Dystrophy

Retinal Dystrophies

Dystrophy, Retinal
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10009 PALS1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PALS1 RGD RGD:1308071
Macaca mulatta PALS1 VGNC VGNC:74794
Canis familiaris PALS1 VGNC VGNC:43346
Felis catus PALS1 VGNC VGNC:80910
Bos taurus PALS1 VGNC VGNC:31584
Mus musculus PALS1 MGD MGI:1927339
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z