AMOT - angiomotin Gene

中文名称：血管动蛋白

种属: Homo sapiens

基因 ID: 154796 | 基因类型: protein coding

关于 AMOT

Cytogenetic location: Xq23 Genomic coordinates (GRCh38): X:112,774,877-112,840,831 (from NCBI)

This gene has 5 transcripts (splice variants), 203 orthologues and 2 paralogues. Broad expression in placenta (RPKM 13.4), brain (RPKM 9.3) and 21 other tissues.

功能概要

该基因属于血管抑制素结合蛋白的运动蛋白家族，其特征在于保守的卷曲螺旋结构域和 C 末端 PDZ 结合基序。编码的蛋白质主要在毛细血管的内皮细胞以及胎盘的较大血管中表达，在那里它可能介导血管抑制素对管形成的抑制作用以及在新血管形成过程中内皮细胞向生长因子的迁移。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

AMOT 基因产物(4)

mRNA	Protein	Name
NM_001113490.2	NP_001106962.1	angiomotin isoform 1
NM_001386998.1	NP_001373927.1	angiomotin isoform 1
NM_001386999.1	NP_001373928.1	angiomotin isoform 1
NM_133265.5	NP_573572.1	angiomotin isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables angiostatin binding	IDA IDA: 通过直接分析推断	11257124	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11257124	GOA
enables signaling receptor activity	IDA IDA: 通过直接分析推断	11257124	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within hippo signaling	IGI IGI: 通过遗传相互作用推断	21205866	GOA
acts upstream of or within negative regulation of angiogenesis	IDA IDA: 通过直接分析推断	11257124	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	21205866	GOA
involved in negative regulation of vascular permeability	IDA IDA: 通过直接分析推断	16043488	GOA
involved in positive regulation of blood vessel endothelial cell migration	IDA IDA: 通过直接分析推断	16043488	GOA
acts upstream of or within regulation of cell migration	IDA IDA: 通过直接分析推断	11257124	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of COP9 signalosome	IDA IDA: 通过直接分析推断	18850735	GOA
located in actin filament	IDA IDA: 通过直接分析推断	11257124	GOA
located in bicellular tight junction	IDA IDA: 通过直接分析推断	16043488	GOA
located in cell surface	IDA IDA: 通过直接分析推断	16043488	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	16043488	GOA
located in endocytic vesicle	IDA IDA: 通过直接分析推断	11257124	GOA
located in external side of plasma membrane	IDA IDA: 通过直接分析推断	11257124	GOA
located in lamellipodium	IDA IDA: 通过直接分析推断	11257124	GOA
located in membrane	IDA IDA: 通过直接分析推断	16043488	GOA
located in ruffle	IDA IDA: 通过直接分析推断	11257124	GOA
located in stress fiber	IDA IDA: 通过直接分析推断	16043488	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AMOT 蛋白结构

Angiomotin_C

0
200
400
600
800
1000
1084 a.a.

蛋白主名

其他名称

angiomotin

AMOT 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	AMOT	Q4VCS5	NF2	Homo sapiens	P35240	Anti Tag CoIP	21481793
种属内	AMOT	Q4VCS5	NF2	Homo sapiens	P35240	Y2H Fragment Pooling	23414517
种属内	AMOT	Q4VCS5	NF2	Homo sapiens	P35240	Anti Tag CoIP	24366813
种属内	AMOT	Q4VCS5	NF2	Homo sapiens	P35240	Anti Tag CoIP	19615732
种属内	AMOT	Q4VCS5	NF2	Homo sapiens	P35240	Anti Bait CoIP	21481793
种属内	AMOT	Q4VCS5	ARHGAP17	Homo sapiens	Q68EM7	Anti Bait CoIP	21481793
种属间	AMOT	Q4VCS5	Nf2	Mus musculus	P46662	Anti Tag CoIP	25026211
种属内	AMOT	Q4VCS5	IKBKG	Homo sapiens	Q9Y6K9	Anti Bait CoIP	30561431

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Papilloma

Papillomatosis

Neurofibromatosis, Type Ii

Neurofibromatosis 2	Neurofibromatosis, Type 2
NF2	Neurofibromatosis Type Ii
Bilateral Acoustic Neurofibromatosis	Banf
Acn	Central Neurofibromatosis
Neurofibromatosis, Central Type	Acoustic Schwannomas, Bilateral
Acoustic Neurinoma, Bilateral	Bilateral Acoustic Neurinoma
Bilateral Acoustic Schwannomas	Familial Acoustic Neuromas

Sveinsson Chorioretinal Atrophy

SCRA	Atrophia Areata
Helicoid Peripapillary Chorioretinal Degeneration	Hpcd
Aa	Peripapillary Chorioretinal Degeneration, Icelandic Type
Helicoidal Peripapillary Chorioretinal Degeneration	Atrophy, Chorioretinal, Sveinsson

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00663	AMOT Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	AMOT	VGNC	VGNC:37835
Felis catus	AMOT	VGNC	VGNC:59769
Rattus norvegicus	AMOT	RGD	RGD:1564027
Mus musculus	AMOT	MGD	MGI:108440
Bos taurus	AMOT	VGNC	VGNC:25870
Macaca mulatta	AMOT	VGNC	VGNC:69627

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