1. Gene
  2. LIN7A - lin-7 homolog A, crumbs cell polarity complex component Gene

LIN7A - lin-7 homolog A, crumbs cell polarity complex component Gene

中文名称:lin-7 同源物 A,碎屑细胞极性复合物组分

种属: Homo sapiens

同用名: LIN7; MALS1; VELI1; LIN-7A; MALS-1; TIP-33

基因 ID: 8825 | 基因类型: protein coding

关于 LIN7A

Cytogenetic location: 12q21.31 Genomic coordinates (GRCh38): 12:80,792,520-80,937,934 (from NCBI)

This gene has 4 transcripts (splice variants), 210 orthologues and 3 paralogues. Broad expression in bone marrow (RPKM 7.9), brain (RPKM 5.7) and 20 other tissues.

功能概要

由该基因编码的蛋白质参与产生和维持细胞膜上通道和受体的不对称分布。编码的蛋白质也是某些特定通道的定位所必需的,并且可以是将突触小泡胞吐作用与大脑中的细胞粘附结合的蛋白质复合物的一部分。[RefSeq 提供,2016 年 5 月]

The protein encoded by this gene is involved in generating and maintaining the asymmetric distribution of channels and receptors at the cell membrane. The encoded protein also is required for the localization of some specific channels and can be part of a protein complex that couples synaptic vesicle exocytosis to cell adhesion in the brain. [provided by RefSeq, May 2016]

LIN7A 基因产物(2)

mRNA Protein Name
NM_001324423.2 NP_001311352.1 protein lin-7 homolog A isoform 2
NM_004664.4 NP_004655.1 protein lin-7 homolog A isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables L27 domain binding IPI
IPI: 通过物理相互作用推断
17237226 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11311936 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

LIN7A 蛋白结构

L27

L27: L27 domain (28 - 83)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (109 - 187)

  • 0
  • 100
  • 200
  • 233 a.a.
蛋白主名 其他名称

protein lin-7 homolog A

mammalian lin-seven protein 1

LIN7A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LIN7A O14910 FAM9B Homo sapiens Q8IZU0 25416956
种属内
LIN7A O14910 MPP2 Homo sapiens Q14168-2 31515488
种属内
LIN7A O14910 MPP2 Homo sapiens Q14168-2 25416956
种属内
LIN7A O14910 MPP2 Homo sapiens Q14168-2 25416956
种属内
LIN7A O14910 CASK Homo sapiens O14936-4 32296183
种属内
LIN7A O14910 CASK Homo sapiens O14936-4 32296183
种属内
LIN7A O14910 CASK Homo sapiens O14936-4 32296183
种属内
LIN7A O14910 CASK Homo sapiens O14936 25416956
种属内
LIN7A O14910 CASK Homo sapiens O14936 24366813
种属内
LIN7A O14910 CASK Homo sapiens O14936 25416956
种属内
LIN7A O14910 MPP2 Homo sapiens Q14168-4 32296183
种属内
LIN7A O14910 MPP2 Homo sapiens Q14168-4 32296183
种属内
LIN7A O14910 MPP2 Homo sapiens Q14168-4 32296183
种属内
LIN7A O14910 PALS1 Homo sapiens Q8N3R9 24366813
种属内
LIN7A O14910 PALS1 Homo sapiens Q8N3R9 31515488
种属内
LIN7A O14910 PALS1 Homo sapiens Q8N3R9 25416956
种属内
LIN7A O14910 PALS1 Homo sapiens Q8N3R9 32296183
种属内
LIN7A O14910 MPP7 Homo sapiens Q5T2T1 32296183
种属内
LIN7A O14910 MPP7 Homo sapiens Q5T2T1 24366813
种属内
LIN7A O14910 MPP7 Homo sapiens Q5T2T1 32296183
种属内
LIN7A O14910 MPP7 Homo sapiens Q5T2T1 32296183
种属内
LIN7A O14910 PALS2 Homo sapiens Q9NZW5 32296183
种属内
LIN7A O14910 PALS2 Homo sapiens Q9NZW5 32296183
种属内
LIN7A O14910 PALS2 Homo sapiens Q9NZW5 24366813
种属内
LIN7A O14910 PALS2 Homo sapiens Q9NZW5 32296183
种属内
LIN7A O14910 ZYX Homo sapiens Q15942 25416956
种属内
LIN7A O14910 ZYX Homo sapiens Q15942 25416956
种属内
LIN7A O14910 ZYX Homo sapiens Q15942 25416956
种属内
LIN7A O14910 MPP3 Homo sapiens Q13368 32296183
种属内
LIN7A O14910 MPP3 Homo sapiens Q13368 32296183
种属内
LIN7A O14910 MPP3 Homo sapiens Q13368 32296183
种属内
LIN7A O14910 MDFI Homo sapiens Q99750 32296183
种属内
LIN7A O14910 MDFI Homo sapiens Q99750 32296183
种属内
LIN7A O14910 MDFI Homo sapiens Q99750 32296183
种属内
LIN7A O14910 NOTCH2NLA Homo sapiens Q7Z3S9 25416956
种属内
LIN7A O14910 NOTCH2NLA Homo sapiens Q7Z3S9 25416956
种属内
LIN7A O14910 NOTCH2NLA Homo sapiens Q7Z3S9 25416956
种属内
LIN7A O14910 CHRD Homo sapiens Q9H2X0 32296183
种属内
LIN7A O14910 ECM1 Homo sapiens Q16610 32296183
种属内
LIN7A O14910 ECM1 Homo sapiens Q16610 32296183
种属内
LIN7A O14910 ECM1 Homo sapiens Q16610 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Chronic Tubotympanic Suppurative Otitis Media

Chronic Tubotympanic Disease

Benign Chronic Suppurative Otitis Media

Chronic Atticoantral Disease

Chronic Atticoantral Suppurative Otitis Media

Persistent Mucosal Disease

Chronic Atticoantral Disorder

Syndromic X-Linked Intellectual Disability Najm Type

Mental Retardation And Microcephaly With Pontine And Cerebellar Hypoplasia

Micpch

X-Linked Intellectual Disability-Microcephaly-Pontocerebellar Hypoplasia Syndrome

Adhesive Otitis Media

Adhesive Middle Ear Disease

Chronic Adhesive Otitis Media

Adhesive Otitis

Fibrotic Adhesive Otitis Media

Adhesive Disorder Of Middle Ear

Retinitis Pigmentosa 12

RP12

Retinitis Pigmentosa With Or Without Paraarteriolar Preservation Of Retinal Pigment Epithelium

Rp With Or Without Preserved Paraarteriole Retinal Pigment Epithelium

Rp With Or Without Pprpe

Retinitis Pigmentosa-12

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

Opitz-Kaveggia Syndrome

Fg Syndrome

Fgs1

Fgs

Keller Syndrome

OKS

Fg Syndrome 1

Fg Syndrome Type 1

Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum

Intellectual Disability, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum

Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of The Corpus Callosum

Leber Plus Disease

Leber Congenital Amaurosis

Lca

Leber'S Amaurosis

Leber'S Disease

Amaurosis Congenita Of Leber

Amaurosis Congenita Of Leber, Type 1

Lhon Plus Disease

Congenital Absence Of The Rods And Cones

Congenital Retinal Blindness

Crb

Congenital Amaurosis Of Retinal Origin

Leber'S Congenital Amaurosis

Leber Congenital Amaurosis 1

Leber'S Congenital Tapetoretinal Degeneration

Leber'S Congenital Tapetoretinal Dysplasia

Lca1

Leber Congenital Amaurosis Type 1

Retinal Blindness, Congenital

Amaurosis, Leber Congenital

Dysgenesis Neuroepithelialis Retinae

Hereditary Epithelial Dysplasia Of Retina

Hereditary Retinal Aplasia

Heredoretinopathia Congenitalis

Leber Abiotrophy

Leber Congenital Tapetoretinal Degeneration

Lebers Congenital Amaurosis

Optic Atrophy, Hereditary, Leber

Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta LIN7A VGNC VGNC:74068
Mus musculus LIN7A MGD MGI:2135609
Bos taurus LIN7A VGNC VGNC:30895
Felis catus LIN7A VGNC VGNC:63233
Rattus norvegicus LIN7A RGD RGD:621256
Canis familiaris LIN7A VGNC VGNC:42686