2. Gene
  3. MPP7 - MAGUK p55 scaffold protein 7 Gene

MPP7 - MAGUK p55 scaffold protein 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：MAGUK p55 支架蛋白 7

种属: Homo sapiens

基因 ID: 143098 | 基因类型: protein coding

关于 MPP7

Cytogenetic location: 10p12.1 Genomic coordinates (GRCh38): 10:28,050,993-28,335,203 (from NCBI)

This gene has 9 transcripts (splice variants), 225 orthologues and 7 paralogues. Ubiquitous expression in esophagus (RPKM 17.1), skin (RPKM 11.1) and 24 other tissues.

功能概要

由该基因编码的蛋白质是膜相关鸟苷酸激酶 (MAGUK) 蛋白 p55 Stardust 家族的成员，其在上皮细胞极性的建立中发挥作用。该家族成员与极性蛋白 DLG1 (圆盘，大同系物 1) 形成复合物，促进上皮细胞极性和紧密连接形成。该基因的多态性与位点特异性骨密度 (BMD) 的变化有关。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 12 月]

The protein encoded by this gene is a member of the p55 Stardust family of membrane-associated guanylate kinase (MAGUK) proteins, which function in the establishment of epithelial cell polarity. This family member forms a complex with the polarity protein DLG1 (discs, large homolog 1) and facilitates epithelial cell polarity and tight junction formation. Polymorphisms in this gene are associated with variations in site-specific bone mineral density (BMD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

MPP7 基因产物(2)

mRNA Protein Name
NM_001318170.2 NP_001305099.1 MAGUK p55 subfamily member 7
NM_173496.5 NP_775767.2 MAGUK p55 subfamily member 7
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables molecular adaptor activity IDA
IDA: 通过直接分析推断
17237226 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17237226 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
17332497 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in bicellular tight junction assembly IDA
IDA: 通过直接分析推断
17332497 GOA
involved in positive regulation of protein-containing complex assembly IDA
IDA: 通过直接分析推断
17237226 GOA
involved in protein localization to adherens junction IMP
IMP: 通过突变表型推断
17237226 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of MPP7-DLG1-LIN7 complex IDA
IDA: 通过直接分析推断
17237226 GOA
located in adherens junction IDA
IDA: 通过直接分析推断
17237226 GOA
located in bicellular tight junction IDA
IDA: 通过直接分析推断
17332497 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MPP7 蛋白结构

L27

L27: L27 domain (13 - 67)

L27

L27: L27 domain (78 - 125)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (141 - 216)

SH3_2

SH3_2: Variant SH3 domain (232 - 295)

Guanylate_kin

Guanylate_kin: Guanylate kinase (368 - 560)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 576 a.a.
蛋白主名 其他名称

MAGUK p55 subfamily member 7

membrane palmitoylated protein 7

MPP7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MPP7 Q5T2T1 LIN7C Homo sapiens Q9NUP9
Validated Y2H
32296183
Intra MPP7 Q5T2T1 DLGAP4 Homo sapiens Q9Y2H0-1
Validated Y2H
32296183
Intra MPP7 Q5T2T1 DLGAP4 Homo sapiens Q9Y2H0-1
Y2H Prey Pooling
32296183
Intra MPP7 Q5T2T1 DLGAP4 Homo sapiens Q9Y2H0-1
Y2H Array
32296183
Intra MPP7 Q5T2T1 MYSM1 Homo sapiens Q5VVJ2
Y2H Prey Pooling
32296183
Intra MPP7 Q5T2T1 MYSM1 Homo sapiens Q5VVJ2
Validated Y2H
32296183
Intra MPP7 Q5T2T1 MYSM1 Homo sapiens Q5VVJ2
Y2H Array
32296183
Intra MPP7 Q5T2T1 TRIM5 Homo sapiens Q9C035-3
Validated Y2H
32296183
Intra MPP7 Q5T2T1 TRIM5 Homo sapiens Q9C035-3
Y2H Prey Pooling
32296183
Intra MPP7 Q5T2T1 LIN7A Homo sapiens O14910
Y2H Prey Pooling
32296183
Intra MPP7 Q5T2T1 LIN7A Homo sapiens O14910
Y2H Array
32296183
Intra MPP7 Q5T2T1 LIN7B Homo sapiens Q9HAP6
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08626 MPP7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus MPP7 MGD MGI:1922989
Macaca mulatta MPP7 VGNC VGNC:74835
Bos taurus MPP7 VGNC VGNC:31586
Rattus norvegicus MPP7 RGD RGD:1305675
Canis familiaris MPP7 VGNC VGNC:49833
Felis catus MPP7 VGNC VGNC:97517
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z