1. Gene
  2. LIN7C - lin-7 homolog C, crumbs cell polarity complex component Gene

LIN7C - lin-7 homolog C, crumbs cell polarity complex component Gene

中文名称:lin-7 同系物 C,碎屑细胞极性复合物组分

种属: Homo sapiens

同用名: MALS3; VELI3; LIN-7C; MALS-3; LIN-7-C

基因 ID: 55327 | 基因类型: protein coding

关于 LIN7C

Cytogenetic location: 11p14.1 Genomic coordinates (GRCh38): 11:27,494,418-27,506,769 (from NCBI)

This gene has 2 transcripts (splice variants), 213 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 9.8), liver (RPKM 7.0) and 25 other tissues.

功能概要

启用 L27 结构域结合活性和细胞骨架蛋白结合活性。参与上皮层的形态发生。位于细胞间连接处;细胞质;和质膜。 MPP7-DLG1-LIN7 复合体的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Enables L27 domain binding activity and cytoskeletal protein binding activity. Involved in morphogenesis of an epithelial sheet. Located in cell-cell junction; cytoplasm; and plasma membrane. Part of MPP7-DLG1-LIN7 complex. [provided by Alliance of Genome Resources, Apr 2022]

LIN7C 基因产物(1)

mRNA Protein Name
NM_018362.4 NP_060832.1 protein lin-7 homolog C
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables L27 domain binding IDA
IDA: 通过直接分析推断
20702775 GOA
enables cytoskeletal protein binding IPI
IPI: 通过物理相互作用推断
17987659 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21849460 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
17237226 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in morphogenesis of an epithelial sheet IMP
IMP: 通过突变表型推断
23201090 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of MPP7-DLG1-LIN7 complex IDA
IDA: 通过直接分析推断
20702775 GOA
located in cell-cell junction IDA
IDA: 通过直接分析推断
23201090 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
23201090 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
21849460 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

LIN7C 蛋白结构

L27

L27: L27 domain (14 - 68)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (94 - 172)

  • 0
  • 100
  • 197 a.a.
蛋白主名 其他名称

protein lin-7 homolog C

LIN-7 protein 3

LIN7C 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LIN7C Q9NUP9 MPP2 Homo sapiens Q14168-4
Y2H Prey Pooling
32296183
种属内
LIN7C Q9NUP9 MPP2 Homo sapiens Q14168-4
Y2H Array
32296183
种属内
LIN7C Q9NUP9 MPP7 Homo sapiens Q5T2T1
Y2H Prey Pooling
32296183
种属内
LIN7C Q9NUP9 MPP7 Homo sapiens Q5T2T1
Y2H Array
32296183
种属内
LIN7C Q9NUP9 MPP7 Homo sapiens Q5T2T1
Anti Tag CoIP
33961781
种属内
LIN7C Q9NUP9 MPP7 Homo sapiens Q5T2T1
Anti Tag CoIP
28514442
种属内
LIN7C Q9NUP9 PALS2 Homo sapiens Q9NZW5
Y2H Prey Pooling
32296183
种属内
LIN7C Q9NUP9 PALS2 Homo sapiens Q9NZW5
Validated Y2H
32296183
种属内
LIN7C Q9NUP9 PALS2 Homo sapiens Q9NZW5
Y2H Array
32296183
种属内
LIN7C Q9NUP9 PALS2 Homo sapiens Q9NZW5
Anti Tag CoIP
33961781
种属内
LIN7C Q9NUP9 PALS2 Homo sapiens Q9NZW5
Anti Tag CoIP
28514442
种属内
LIN7C Q9NUP9 MPP3 Homo sapiens Q13368
Anti Tag CoIP
33961781
种属内
LIN7C Q9NUP9 MPP3 Homo sapiens Q13368
Y2H Array
32296183
种属内
LIN7C Q9NUP9 MPP3 Homo sapiens Q13368
Anti Tag CoIP
28514442
种属内
LIN7C Q9NUP9 MPP3 Homo sapiens Q13368
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity

Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome

Wagr Syndrome

11p Partial Monosomy Syndrome

Chromosome 11p13 Deletion Syndrome

Wilms Tumor, Aniridia, Genitourinary Anomalies And Mental Retardation Syndrome

11p Deletion Syndrome

Chromosome 11p Deletion Syndrome

Wagr Complex

Wilms Tumor-Aniridia-Genitourinary Anomalies-Intellectual Disability Syndrome

Deletion 11p13

WAGR

Wilms Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome

Chromosome 11p Deletion

11p Deletion

11p Monosomy

Deletion 11p

Monosomy 11p

Partial Monosomy 11p

Agr Triad

Wilms Tumor-Aniridia-Gonadoblastoma-Mental Retardation Syndrome

Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation Syndrome

Wagr Contiguous Gene Syndrome

Wilms Tumor-Aniridia-Genital Anomalies-Retardation Syndrome

Wilms Tumor-Aniridia-Genitourinary Anomalies-Mr Syndrome

Del(11)(P13)

Monosomy 11p13

Chromosome 11, Deletion 11p

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus LIN7C VGNC VGNC:82034
Macaca mulatta LIN7C VGNC VGNC:74070
Mus musculus LIN7C MGD MGI:1330839
Rattus norvegicus LIN7C RGD RGD:621164
Bos taurus LIN7C VGNC VGNC:30897