2. Gene
  3. LIN7B - lin-7 homolog B, crumbs cell polarity complex component Gene

LIN7B - lin-7 homolog B, crumbs cell polarity complex component Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：lin-7 同系物 B，碎屑细胞极性复合物成分

种属: Homo sapiens

同用名: MALS2; VELI2; LIN-7B; MALS-2

基因 ID: 64130 | 基因类型: protein coding

关于 LIN7B

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,114,370-49,118,460 (from NCBI)

This gene has 7 transcripts (splice variants), 181 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 4.4), testis (RPKM 3.8) and 25 other tissues.

功能概要

启用蛋白质域特异性结合活性。预计参与上皮细胞顶端/基底极性的维持；神经递质分泌；和蛋白质定位到基底外侧质膜。预测位于质膜中。预计是 MPP7-DLG1-LIN7 复合体的一部分。预计在基底外侧质膜上有活性；细胞-细胞连接；和突触。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein domain specific binding activity. Predicted to be involved in maintenance of epithelial cell apical/basal polarity; neurotransmitter secretion; and protein localization to basolateral plasma membrane. Predicted to be located in plasma membrane. Predicted to be part of MPP7-DLG1-LIN7 complex. Predicted to be active in basolateral plasma membrane; cell-cell junction; and synapse. [provided by Alliance of Genome Resources, Apr 2022]

LIN7B 基因产物(2)

mRNA Protein Name
NM_001308419.2 NP_001295348.1 protein lin-7 homolog B isoform 2
NM_022165.3 NP_071448.1 protein lin-7 homolog B isoform 1

LIN7B 蛋白结构

L27

L27: L27 domain (13 - 67)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (94 - 172)

  • 0
  • 100
  • 207 a.a.
蛋白主名 其他名称

protein lin-7 homolog B

hLin7B

LIN7B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LIN7B Q9HAP6 CASK Homo sapiens O14936-4
Y2H Prey Pooling
32296183
种属内
LIN7B Q9HAP6 CASK Homo sapiens O14936-4
Y2H Array
32296183
种属内
LIN7B Q9HAP6 MPP2 Homo sapiens Q14168-4
Y2H Prey Pooling
32296183
种属内
LIN7B Q9HAP6 MPP2 Homo sapiens Q14168-4
Y2H Array
32296183
种属内
LIN7B Q9HAP6 PALS1 Homo sapiens Q8N3R9
Anti Tag CoIP
33961781
种属内
LIN7B Q9HAP6 MPP7 Homo sapiens Q5T2T1
Anti Tag CoIP
33961781
种属内
LIN7B Q9HAP6 MPP7 Homo sapiens Q5T2T1
Y2H Prey Pooling
32296183
种属内
LIN7B Q9HAP6 MPP7 Homo sapiens Q5T2T1
Y2H Array
32296183
种属内
LIN7B Q9HAP6 PALS2 Homo sapiens Q9NZW5
Y2H Prey Pooling
32296183
种属内
LIN7B Q9HAP6 PALS2 Homo sapiens Q9NZW5
Validated Y2H
32296183
种属内
LIN7B Q9HAP6 PALS2 Homo sapiens Q9NZW5
Y2H Array
32296183
种属内
LIN7B Q9HAP6 PALS2 Homo sapiens Q9NZW5
Anti Tag CoIP
33961781
种属内
LIN7B Q9HAP6 MPP3 Homo sapiens Q13368
Y2H Prey Pooling
32296183
种属内
LIN7B Q9HAP6 MPP3 Homo sapiens Q13368
Y2H Array
32296183
种属内
LIN7B Q9HAP6 MPP3 Homo sapiens Q13368
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity
Huntington Disease

Huntington'S Disease

Huntington Chorea

Huntington'S Chorea

HD

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07677 LIN7B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris LIN7B VGNC VGNC:53735
Macaca mulatta LIN7B VGNC VGNC:74069
Mus musculus LIN7B MGD MGI:1330858
Rattus norvegicus LIN7B RGD RGD:620730
Bos taurus LIN7B VGNC VGNC:30896
Felis catus LIN7B VGNC VGNC:63234
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