2. Gene
  3. PATJ - PATJ crumbs cell polarity complex component Gene

PATJ - PATJ crumbs cell polarity complex component Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：PATJ 碎屑细胞极性复杂成分

种属: Homo sapiens

同用名: Cipp; INADL; hINADL; InaD-like

基因 ID: 10207 | 基因类型: protein coding

关于 PATJ

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:61,742,480-62,163,915 (from NCBI)

This gene has 16 transcripts (splice variants), 241 orthologues and 5 paralogues. Broad expression in kidney (RPKM 14.4), heart (RPKM 7.9) and 24 other tissues.

功能概要

该基因编码具有多个 PDZ 结构域的蛋白质。 PDZ 结构域介导蛋白质-蛋白质相互作用，具有多个 PDZ 结构域的蛋白质通常在质膜上组织多聚体复合物。这种蛋白质定位于紧密连接和上皮细胞的顶膜。果蝇中的一种类似蛋白质是一种脚手架蛋白，它连接光感受器中多聚体信号复合体的几个成员。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors. [provided by RefSeq, Jul 2008]

PATJ 基因产物(2)

mRNA Protein Name
NM_001350145.3 NP_001337074.2 inaD-like protein isoform 2
NM_176877.5 NP_795352.3 inaD-like protein isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11927608 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in bicellular tight junction IDA
IDA: 通过直接分析推断
22006950 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
18596123 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PATJ 蛋白结构

L27_2

L27_2: L27_2 (8 - 65)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (136 - 217)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (254 - 324)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (367 - 449)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (570 - 632)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (690 - 767)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (1071 - 1153)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (1241 - 1317)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (1439 - 1516)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (1535 - 1611)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (1677 - 1758)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1801 a.a.
蛋白主名 其他名称

inaD-like protein

PALS1-associated tight junction protein

PATJ 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PATJ Q8NI35 PALS1 Homo sapiens Q8N3R9
Anti Tag CoIP
11927608
种属内
PATJ Q8NI35 PALS1 Homo sapiens Q8N3R9
Anti Bait CoIP
11927608
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Retinitis Pigmentosa 12

RP12

Retinitis Pigmentosa With Or Without Paraarteriolar Preservation Of Retinal Pigment Epithelium

Rp With Or Without Preserved Paraarteriole Retinal Pigment Epithelium

Rp With Or Without Pprpe

Retinitis Pigmentosa-12
Retinal Degeneration

Degeneration Of Retina
Intraorbital Meningioma
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Meckel Syndrome, Type 1

Meckel-Gruber Syndrome

Meckel Syndrome

Dysencephalia Splanchnocystica

Meckel Syndrome 1

MKS1

Mks

Gruber Syndrome

Meckel-Gruber Syndrome, Type 1

Mes

Dysencephalia Splachnocystica

Meckel Gruber Syndrome

Meckel Syndrome Type 1
Leber Plus Disease

Leber Congenital Amaurosis

Lca

Leber'S Amaurosis

Leber'S Disease

Amaurosis Congenita Of Leber

Amaurosis Congenita Of Leber, Type 1

Lhon Plus Disease

Congenital Absence Of The Rods And Cones

Congenital Retinal Blindness

Crb

Congenital Amaurosis Of Retinal Origin

Leber'S Congenital Amaurosis

Leber Congenital Amaurosis 1

Leber'S Congenital Tapetoretinal Degeneration

Leber'S Congenital Tapetoretinal Dysplasia

Lca1

Leber Congenital Amaurosis Type 1

Retinal Blindness, Congenital

Amaurosis, Leber Congenital

Dysgenesis Neuroepithelialis Retinae

Hereditary Epithelial Dysplasia Of Retina

Hereditary Retinal Aplasia

Heredoretinopathia Congenitalis

Leber Abiotrophy

Leber Congenital Tapetoretinal Degeneration

Lebers Congenital Amaurosis

Optic Atrophy, Hereditary, Leber
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10083 PATJ Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PATJ VGNC VGNC:32592
Canis familiaris PATJ VGNC VGNC:44271
Mus musculus PATJ MGD MGI:1277960
Macaca mulatta PATJ VGNC VGNC:100026
Rattus norvegicus PATJ RGD RGD:1565362
Felis catus PATJ VGNC VGNC:82535
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