2. Vitamin D Related/Nuclear Receptor Autophagy
  3. Nuclear Hormone Receptor 4A/NR4A p62
  4. Triptohypol C

Triptohypol C，Tripterin (HY-13067) 的衍生物，是一种有效的靶向 Nur77 的抗炎剂，Kd 为 0.87 μM。Triptohypol C 通过促进 Nur77 与 TRAF2 和 p62/SQSTM1 的相互作用抑制炎症反应。

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Triptohypol C Chemical Structure

Triptohypol C Chemical Structure

CAS No. : 193957-88-9

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10 mg ￥5800
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Customer Review

Triptohypol C 相关抗体

Top Publications Citing Use of Products

查看 Nuclear Hormone Receptor 4A/NR4A 亚型特异性产品:

查看所有亚型
Nurr1/NR4A2 Nur77/NR4A1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Triptohypol C, a Tripterin (HY-13067) derivative, is a potent Nur77-targeting anti-inflammatory agent with an Kd value of 0.87 μM. Triptohypol C inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1[1].

IC50 & Target

Nur77/NR4A1

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
3.15 μM
Compound: 2
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
[PMID: 28865279]
A549 IC50
3.15 μM
Compound: 2
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
[PMID: 28688281]
MIA PaCa-2 IC50
0.72 μM
Compound: 2
Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay
Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay
[PMID: 28865279]
MIA PaCa-2 IC50
0.72 μM
Compound: 2
Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay
Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay
[PMID: 28688281]
体外研究
(In Vitro)

Triptohypol C (compound 3a) (2 μM; 1 h) strongly antagonize the effect of TNFα on inducing IκBα degradation, and inhibits inflammatory response by promoting the interactions of Nur77 with TRAF2 and p62/SQSTM1[1].
Triptohypol C (2 μM; 10 h) cause 3.12% apoptosis in HepG2 cells, which is less toxic than Tripterin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Triptohypol C 相关抗体:

Western Blot Analysis[1]

Cell Line: Lysates from HepG2 cells (incubated with 20 ng/mL TNFα for 30 min)
Concentration: 2 μM
Incubation Time: 1 h
Result: Strongly antagonized the effect of TNFα on inducing IκBα degradation

Immunofluorescence[1]

Cell Line: HepG2 cells (transfected with Myc-Nur77 and Flag-TRAF2 or Flag-p62)
Concentration: 2 μM
Incubation Time: 1 h
Result: Promoted the interactions between Nur77 and TRAF2 and p62/SQSTM1.

Apoptosis Analysis[1]

Cell Line: HepG2 cells
Concentration: 2 μM
Incubation Time: 10 h
Result: Caused 3.12% apoptosis in cells, which was less cytotoxic than Tripterin (>10%).
体内研究
(In Vivo)

Caused 3.12% apoptosis in cells, which was less cytotoxic than Tripterin (>10%).

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zebrafish[1]
Dosage: 0.5 μM, 1 μM and 1.25 μM
Administration: 72 h
Result: Had less effect than Tripterin on the death rate and malformation of zebrafish either at a concentration of 1.25 μM for 24 h or at a concentration of 0.5 μM for 72 h.
分子量

452.63

Formula

C29H40O4
CAS 号
性状

固体

颜色

Light yellow to yellow

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 16.67 mg/mL (36.83 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2093 mL 11.0465 mL 22.0931 mL
5 mM 0.4419 mL 2.2093 mL 4.4186 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 95.44%

COA (268 KB) HNMR (186 KB) RP-HPLC (183 KB)

产品使用指南 (1538 KB)
参考文献

Triptohypol C 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2093 mL 11.0466 mL 22.0931 mL 55.2328 mL
5 mM 0.4419 mL 2.2093 mL 4.4186 mL 11.0466 mL
10 mM 0.2209 mL 1.1047 mL 2.2093 mL 5.5233 mL
15 mM 0.1473 mL 0.7364 mL 1.4729 mL 3.6822 mL
20 mM 0.1105 mL 0.5523 mL 1.1047 mL 2.7616 mL
25 mM 0.0884 mL 0.4419 mL 0.8837 mL 2.2093 mL
30 mM 0.0736 mL 0.3682 mL 0.7364 mL 1.8411 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Triptohypol C193957-88-9Nuclear Hormone Receptor 4A/NR4Ap62Nerve Growth Factor IB-like ReceptorSequestosome-1SQSTM1Nur77Tripterinanti-inflammatoryTRAF2p62/SQSTM1HepG2 cellsTNFαIκBαzebrafishInhibitorinhibitorinhibit

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