ZKSCAN3 - zinc finger with KRAB and SCAN domains 3 Gene

中文名称：具有 KRAB 和 SCAN 结构域的锌指 3

种属: Homo sapiens

同用名: ZF47; Zfp47; ZFP306; ZNF306; ZNF309; zfp-47; ZSCAN13; ZSCAN35; dJ874C20.1; dJ874C20.1.

基因 ID: 80317 | 基因类型: protein coding

关于 ZKSCAN3

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:28,349,878-28,369,172 (from NCBI)

This gene has 3 transcripts (splice variants), 38 orthologues and 31 paralogues. Ubiquitous expression in thyroid (RPKM 1.5), ovary (RPKM 1.5) and 25 other tissues.

功能概要

启用 DNA 结合转录抑制活性，RNA 聚合酶 II 特异性； RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性；和染色质结合活性。参与多个过程，包括自噬的负调控；细胞衰老的负调节；和转录调控，DNA 模板化。位于细胞质和核质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including negative regulation of autophagy; negative regulation of cellular senescence; and regulation of transcription, DNA-templated. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZKSCAN3 基因产物(3)

mRNA	Protein	Name
NM_001242894.2	NP_001229823.1	zinc finger protein with KRAB and SCAN domains 3 isoform 1
NM_001242895.2	NP_001229824.1	zinc finger protein with KRAB and SCAN domains 3 isoform 2
NM_024493.4	NP_077819.2	zinc finger protein with KRAB and SCAN domains 3 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	18940803	GOA
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	23434374	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	18940803	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	18940803	GOA
enables chromatin binding	IDA IDA: 通过直接分析推断	18940803	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	23434374	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in lysosome organization	IMP IMP: 通过突变表型推断	23434374	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	23434374	GOA
involved in negative regulation of autophagy	IMP IMP: 通过突变表型推断	23434374	GOA
involved in negative regulation of cellular senescence	IMP IMP: 通过突变表型推断	23434374	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	18940803	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	18940803	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	23434374	GOA
located in nucleus	IDA IDA: 通过直接分析推断	18940803	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZKSCAN3 蛋白结构

SCAN

KRAB

zf-H2C2_2

0
100
200
300
400
500
538 a.a.

蛋白主名

其他名称

zinc finger protein with KRAB and SCAN domains 3

zinc finger and SCAN domain-containing protein 13

ZKSCAN3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	ZKSCAN3	Q9BRR0	FKBP1A	Homo sapiens	Q0VDC6	Y2H Pooling	32814053
Intra	ZKSCAN3	Q9BRR0	FKBP1A	Homo sapiens	Q0VDC6	Validated Y2H	32814053
Intra	ZKSCAN3	Q9BRR0	FKBP1A	Homo sapiens	Q0VDC6	Y2H Array	32814053
Intra	ZKSCAN3	Q9BRR0	SARS1	Homo sapiens	P49591	Validated Y2H	32814053
Intra	ZKSCAN3	Q9BRR0	SARS1	Homo sapiens	P49591	Y2H Array	32814053
Intra	ZKSCAN3	Q9BRR0	SARS1	Homo sapiens	P49591	Y2H Pooling	32814053
Intra	ZKSCAN3	Q9BRR0	EIF2S3	Homo sapiens	P41091	Validated Y2H	32814053
Intra	ZKSCAN3	Q9BRR0	EIF2S3	Homo sapiens	P41091	Y2H Array	32814053
Intra	ZKSCAN3	Q9BRR0	EIF2S3	Homo sapiens	P41091	Y2H Pooling	32814053
Intra	ZKSCAN3	Q9BRR0	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	ZKSCAN3	Q9BRR0	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	ZKSCAN3	Q9BRR0	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	ZKSCAN3	Q9BRR0	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	ZKSCAN3	Q9BRR0	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	ZKSCAN3	Q9BRR0	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	ZKSCAN3	Q9BRR0	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	ZKSCAN3	Q9BRR0	MDM4	Homo sapiens	O15151	Y2H Array	32296183
Intra	ZKSCAN3	Q9BRR0	MDM4	Homo sapiens	O15151	Y2H Prey Pooling	32296183
Intra	ZKSCAN3	Q9BRR0	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	ZKSCAN3	Q9BRR0	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	ZKSCAN3	Q9BRR0	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	ZKSCAN3	Q9BRR0	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	ZKSCAN3	Q9BRR0	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	ZKSCAN3	Q9BRR0	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	ZKSCAN3	Q9BRR0	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	ZKSCAN3	Q9BRR0	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	ZKSCAN3	Q9BRR0	IHO1	Homo sapiens	Q8IYA8	Y2H Array	32296183
Intra	ZKSCAN3	Q9BRR0	IHO1	Homo sapiens	Q8IYA8	Y2H Prey Pooling	32296183
Intra	ZKSCAN3	Q9BRR0	PDE4DIP	Homo sapiens	Q5VU43-2	Y2H Array	32296183
Intra	ZKSCAN3	Q9BRR0	PDE4DIP	Homo sapiens	Q5VU43-2	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Non-Invasive Bladder Papillary Urothelial Neoplasm

Bladder Papillary Neoplasm Of Low Malignant Potential	Bladder Punlmp
Papillary Urothelial Neoplasm Of Low Malignant Potential	Papillary Transitional Cell Neoplasm Of Low Malignant Potential

Ureteral Benign Neoplasm

Neoplasm Of Ureter	Ureteral Tumor
Cancer Of The Ureter	Malignant Tumour Of Ureter
Ureteric Cancer	Primary Malignant Neoplasm Of Ureter

Alzheimer Disease 4

AD4	Alzheimer Disease-4
Alzheimer'S Disease 4	Alzheimer Disease, Familial, 4
Alzheimer Disease, Familial4	Alzheimer'S Disease 4, Early Onset
Alzheimer Disease, Type 4

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS16082	ZKSCAN3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	ZKSCAN3	VGNC	VGNC:78938
Rattus norvegicus	ZKSCAN3	RGD	RGD:1305753
Mus musculus	ZKSCAN3	MGD	MGI:1919989

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