2. Gene
  3. Ngfr - nerve growth factor receptor Gene

Ngfr - nerve growth factor receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: p75; LNGFR; p75NTR; RNNGFRR; Tnfrsf16

基因 ID: 24596 | 基因类型: protein coding

关于 Ngfr

功能概要

Enables several functions, including amyloid-beta binding activity; nerve growth factor binding activity; and neurotrophin TrkA receptor binding activity. Involved in several processes, including positive regulation of cell communication; regulation of neuron death; and regulation of neuron projection development. Located in several cellular components, including dendrite membrane; neuronal cell body membrane; and perikaryon. Used to study degenerative disc disease; glaucoma; hypertension; and middle cerebral artery infarction. Biomarker of several diseases, including brain disease (multiple); neuropathy (multiple); polycystic ovary syndrome; portal hypertension; and respiratory syncytial virus infectious disease. Human ortholog(s) of this gene implicated in Alzheimer's disease and mental depression. Orthologous to human NGFR (nerve growth factor receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ngfr 基因产物(1)

mRNA Protein Name
NM_012610.2 NP_036742.2 tumor necrosis factor receptor superfamily member 16 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables amyloid-beta binding IPI
IPI: 通过物理相互作用推断
19334058 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
11756426 RGD
enables nerve growth factor binding IDA
IDA: 通过直接分析推断
3027580 RGD
enables neurotrophin TRKA receptor binding IPI
IPI: 通过物理相互作用推断
9753156 RGD
enables neurotrophin binding IPI
IPI: 通过物理相互作用推断
18596692 RGD
enables preprotein binding IPI
IPI: 通过物理相互作用推断
20036257 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10485890 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
23613963 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to oxidative stress IMP
IMP: 通过突变表型推断
19457114 RGD
involved in negative regulation of angiogenesis IMP
IMP: 通过突变表型推断
23920372 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
23920372 RGD
involved in negative regulation of dendritic spine development IMP
IMP: 通过突变表型推断
22548193 RGD
involved in negative regulation of mitochondrial depolarization IMP
IMP: 通过突变表型推断
19457114 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
11438587 RGD
involved in negative regulation of neuron projection development IDA
IDA: 通过直接分析推断
18786176 RGD
involved in positive regulation of MAPK cascade IDA
IDA: 通过直接分析推断
12929129 RGD
involved in positive regulation of Rho protein signal transduction IDA
IDA: 通过直接分析推断
18786176 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
21539892 RGD
involved in positive regulation of excitatory postsynaptic potential IMP
IMP: 通过突变表型推断
23114219 RGD
involved in positive regulation of myelination IMP
IMP: 通过突变表型推断
12424382 RGD
involved in positive regulation of neural precursor cell proliferation IMP
IMP: 通过突变表型推断
23940017 RGD
involved in positive regulation of neuron differentiation IDA
IDA: 通过直接分析推断
23940017 RGD
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
22292018 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
19457114 RGD
involved in positive regulation of synaptic transmission, cholinergic IMP
IMP: 通过突变表型推断
18256260 RGD
involved in positive regulation of synaptic transmission, glutamatergic IMP
IMP: 通过突变表型推断
18256260 RGD
involved in regulation of reactive oxygen species metabolic process IMP
IMP: 通过突变表型推断
19457114 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
9267539 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
21084570 RGD
involved in skeletal muscle cell differentiation IEP
IEP: 通过表达模式推断
16723531 RGD
involved in spermatogenesis IEP
IEP: 通过表达模式推断
1315318 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in clathrin-coated endocytic vesicle IDA
IDA: 通过直接分析推断
17897318 RGD
located in dendrite membrane IDA
IDA: 通过直接分析推断
9521535 RGD
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
9521535 RGD
located in mitochondrion IDA
IDA: 通过直接分析推断
22138126 RGD
is active in neuromuscular junction IDA
IDA: 通过直接分析推断
20433604 RGD
located in neuronal cell body membrane IDA
IDA: 通过直接分析推断
9521535 RGD
located in nuclear envelope IDA
IDA: 通过直接分析推断
9521535 RGD
located in perikaryon IDA
IDA: 通过直接分析推断
9767155 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
20433604 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tumor necrosis factor receptor superfamily member 16

NGF receptor

gp80-LNGFR

low affinity nerve growth factor receptor

low affinity neurotrophin receptor p75NTR

nerve growth factor receptor (TNFR superfamily, member 16)

nerve growth factor receptor, fast

p75 ICD

Ngfr 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra Ngfr P07174 NGF Homo sapiens P01138
X-Ray Diffraction
15131306
Intra Ngfr P07174 Ngf Mus musculus P01139
Solution Sedimentation
18596692
Cross Ngfr P07174 TRAF2 Homo sapiens Q12933
Anti Tag CoIP
10514511
Cross Ngfr P07174 TRAF6 Homo sapiens Q9Y4K3
Anti Tag CoIP
10514511
Intra Ngfr P07174 Ngfr Rattus norvegicus P07174
Crosslink
11756426
Intra Ngfr P07174 Ngfr Rattus norvegicus P07174
Solution Sedimentation
18596692
Cross Ngfr P07174 TRAF4 Homo sapiens Q9BUZ4
Anti Tag CoIP
10514511
Cross Ngfr P07174 TRAF2 Homo sapiens Q12933
Pull Down
10514511
Cross Ngfr P07174 TRAF6 Homo sapiens Q9Y4K3
Anti Tag CoIP
21541365
Cross Ngfr P07174 P05067-PRO_0000000093 Homo sapiens P05067-PRO_0000000093
Anti Bait CoIP
11756426
Intra Ngfr P07174 Ntrk1 Rattus norvegicus P35739
Anti Bait CoIP
19549834
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-111163 NSC49652 Inducer 99.92% 否
HY-RS09278 NGFR Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ngfr NCBI NCBI:4804
Mus musculus Ngfr NCBI NCBI:18053
Leporidae Ngfr NCBI
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