1. Gene
  2. NMUR2 - neuromedin U receptor 2 Gene

NMUR2 - neuromedin U receptor 2 Gene

中文名称:神经调节素 U 受体 2

种属: Homo sapiens

同用名: FM4; FM-4; TGR1; NMU2R; TGR-1; NMU-R2

基因 ID: 56923 | 基因类型: protein coding

关于 NMUR2

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:152,391,546-152,405,279 (from NCBI)

This gene has 2 transcripts (splice variants), 131 orthologues and 15 paralogues. Low expression observed in reference dataset.

功能概要

该基因编码来自 G 蛋白偶联受体 1 家族的蛋白质。这种蛋白质是神经调节素 U 的受体,神经调节素 U 是一种广泛分布于肠道和中枢神经系统的神经肽。该受体在调节食物摄入和体重方面起着重要作用。[RefSeq 提供,2008 年 7 月]

This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. [provided by RefSeq, Jul 2008]

NMUR2 基因产物(1)

mRNA Protein Name
NM_020167.5 NP_064552.3 neuromedin-U receptor 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTP binding IDA
IDA: 通过直接分析推断
10899166 GOA
enables intracellularly calcium-gated chloride channel activity IDA
IDA: 通过直接分析推断
10899166 GOA
enables neuromedin U binding IDA
IDA: 通过直接分析推断
10894543 GOA
enables neuromedin U receptor activity IDA
IDA: 通过直接分析推断
10887190 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in arachidonate secretion IDA
IDA: 通过直接分析推断
10887190 GOA
involved in neuropeptide signaling pathway IDA
IDA: 通过直接分析推断
10894543 GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
10899166 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
10899166 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NMUR2 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (62 - 327)

  • 0
  • 100
  • 200
  • 300
  • 415 a.a.
蛋白主名 其他名称

neuromedin-U receptor 2

G-protein coupled receptor FM-4

NMUR2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NMUR2 Q9GZQ4 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
25416956
种属内
NMUR2 Q9GZQ4 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
25416956
种属内
NMUR2 Q9GZQ4 TRAF2 Homo sapiens Q12933
Y2H Array
25416956
种属内
NMUR2 Q9GZQ4 TCF4 Homo sapiens P15884
Validated Y2H
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris NMUR2 VGNC VGNC:43867
Felis catus NMUR2 VGNC VGNC:63842
Bos taurus NMUR2 VGNC VGNC:32141
Rattus norvegicus NMUR2 RGD RGD:621155
Mus musculus NMUR2 MGD MGI:2441765
Macaca mulatta NMUR2 VGNC VGNC:75189