1. Gene
  2. MAP3K14 - mitogen-activated protein kinase kinase kinase 14 Gene

MAP3K14 - mitogen-activated protein kinase kinase kinase 14 Gene

中文名称:丝裂原活化蛋白激酶激酶 14

种属: Homo sapiens

同用名: HS; NIK; HSNIK; FTDCR1B

基因 ID: 9020 | 基因类型: protein coding

关于 MAP3K14

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:45,263,119-45,317,020 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 241 orthologues, 35 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 11.1), spleen (RPKM 8.5) and 25 other tissues.

功能概要

该基因编码丝裂原活化蛋白激酶激酶激酶 14,它是一种丝氨酸/苏氨酸蛋白激酶。这种激酶与 TRAF2 结合并刺激 NF-kappaB 活性。它与其他几种 MAPKK 激酶具有序列相似性。它参与了肿瘤坏死/神经生长因子 (TNF/NGF) 家族受体和白细胞介素 1 I 型受体共有的 NF-kappaB 诱导信号级联。[RefSeq 提供,2008 年 7 月]

This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]

MAP3K14 基因产物(1)

mRNA Protein Name
NM_003954.5 NP_003945.2 mitogen-activated protein kinase kinase kinase 14
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9020361 GOA
enables protein kinase activity IDA
IDA: 通过直接分析推断
15001576 GOA
enables protein serine/threonine kinase activity EXP
EXP: 通过实验结果推断
9520446 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
19593445 GOA
involved in defense response to virus IDA
IDA: 通过直接分析推断
21478870 GOA
involved in non-canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
10094049 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

mitogen-activated protein kinase kinase kinase 14

NF-kappa-beta-inducing kinase

MAP3K14 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra MAP3K14 Q99558 RPS11 Homo sapiens P62280
Anti Tag CoIP
31980649
Intra MAP3K14 Q99558 KPNB1 Homo sapiens Q14974
Pull Down
30833792
Intra MAP3K14 Q99558 CDC37 Homo sapiens Q16543
Lumier
25036637
Intra MAP3K14 Q99558 CDC37 Homo sapiens Q16543
Pull Down
30833792
Intra MAP3K14 Q99558 CDC37 Homo sapiens Q16543
Anti Tag CoIP
31980649
Intra MAP3K14 Q99558 CDC37 Homo sapiens Q16543
Pull Down
32707033
Intra MAP3K14 Q99558 HSP90AA1 Homo sapiens P07900
Anti Tag CoIP
31980649
Intra MAP3K14 Q99558 HSP90AA1 Homo sapiens P07900
Pull Down
30833792
Intra MAP3K14 Q99558 HSP90AA1 Homo sapiens P07900
Pull Down
32707033
Intra MAP3K14 Q99558 RPL4 Homo sapiens P36578
Anti Tag CoIP
31980649
Intra MAP3K14 Q99558 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra MAP3K14 Q99558 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra MAP3K14 Q99558 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra MAP3K14 Q99558 RPS13 Homo sapiens P62277
Anti Tag CoIP
31980649
Intra MAP3K14 Q99558 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
Intra MAP3K14 Q99558 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra MAP3K14 Q99558 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
31980649
Intra MAP3K14 Q99558 TRAF2 Homo sapiens Q12933
Anti Tag CoIP
31980649
Intra MAP3K14 Q99558 TRAF2 Homo sapiens Q12933
Y2H
9020361
Intra MAP3K14 Q99558 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
25416956
Intra MAP3K14 Q99558 TRAF2 Homo sapiens Q12933
Y2H Array
25416956
Intra MAP3K14 Q99558 TRAF3 Homo sapiens Q13114
Y2H Prey Pooling
32296183
Intra MAP3K14 Q99558 TRAF3 Homo sapiens Q13114
Anti Tag CoIP
31980649
Intra MAP3K14 Q99558 TRAF3 Homo sapiens Q13114
Y2H Array
32296183
Intra MAP3K14 Q99558 TRAF3 Homo sapiens Q13114
Anti Tag CoIP
33961781
Intra MAP3K14 Q99558 TRAF3 Homo sapiens Q13114
Anti Tag CoIP
28514442
Intra MAP3K14 Q99558 TRAF3 Homo sapiens Q13114
Pull Down
32707033
Intra MAP3K14 Q99558 TRAF3 Homo sapiens Q13114
Pull Down
30833792
Intra MAP3K14 Q99558 RPL6 Homo sapiens Q02878
Anti Tag CoIP
31980649
Intra MAP3K14 Q99558 RPL8 Homo sapiens P62917
Anti Tag CoIP
31980649
Intra MAP3K14 Q99558 CHUK Homo sapiens O15111
Pull Down
30833792
Intra MAP3K14 Q99558 CHUK Homo sapiens O15111
Pull Down
32707033
Intra MAP3K14 Q99558 CHUK Homo sapiens O15111
Protein Kinase Assay
9520446
Intra MAP3K14 Q99558 CHUK Homo sapiens O15111
Anti Bait CoIP
16498412
Intra MAP3K14 Q99558 CHUK Homo sapiens O15111
Anti Tag CoIP
33961781
Intra MAP3K14 Q99558 CHUK Homo sapiens O15111
Anti Tag CoIP
28514442
Intra MAP3K14 Q99558 CHUK Homo sapiens O15111
Anti Tag CoIP
31980649
Intra MAP3K14 Q99558 IKBKB Homo sapiens O14920
Anti Tag CoIP
33961781
Intra MAP3K14 Q99558 IKBKB Homo sapiens O14920
Pull Down
30833792
Intra MAP3K14 Q99558 IKBKB Homo sapiens O14920
Anti Tag CoIP
28514442
Intra MAP3K14 Q99558 IKBKB Homo sapiens O14920
Pull Down
32707033
Intra MAP3K14 Q99558 IKBKB Homo sapiens O14920
Protein Kinase Assay
9520446
Intra MAP3K14 Q99558 IKBKG Homo sapiens Q9Y6K9
Anti Tag CoIP
31980649
Intra MAP3K14 Q99558 IKBKG Homo sapiens Q9Y6K9
Anti Tag CoIP
33961781
Intra MAP3K14 Q99558 IKBKG Homo sapiens Q9Y6K9
Pull Down
32707033
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nik Deficiency

Primary Immunodeficiency With Multifaceted Aberrant Lymphoid Immunity

Pancreatic Ductal Adenocarcinoma

Ductal Adenocarcinoma Of The Pancreas

Immunodeficiency 50

Combined Immunodeficiency Due To Moesin Deficiency

IMD50

Immunodeficiency 50, X-Linked Recessive

Cid Due To Moesin Deficiency

Msn-Related Combined Immunodeficiency

X-Linked Moesin-Associated Immunodeficiency

Immunodeficiency 50 X Linked Recessive

Pancreatic Adenosquamous Carcinoma

Adenosquamous Carcinoma Of Pancreas

Adenosquamous Carcinoma Of The Pancreas

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Ectodermal Dysplasia

Congenital Ectodermal Defect

Congenital Ectodermal Dysplasia

Ectodermal Dysplasia Syndrome

Dysplasia, Ectodermal

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MAP3K14 RGD RGD:1310487
Bos taurus MAP3K14 VGNC VGNC:31192
Felis catus MAP3K14 VGNC VGNC:99219
Mus musculus MAP3K14 MGD MGI:1858204
Macaca mulatta MAP3K14 VGNC VGNC:81459
Canis familiaris MAP3K14 VGNC VGNC:42970