1. Gene
  2. ZNF410 - zinc finger protein 410 Gene

ZNF410 - zinc finger protein 410 Gene

中文名称:锌指蛋白 410

种属: Homo sapiens

同用名: APA1; APA-1

基因 ID: 57862 | 基因类型: protein coding

关于 ZNF410

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:73,886,859-73,932,521 (from NCBI)

This gene has 23 transcripts (splice variants), 212 orthologues and 36 paralogues. Ubiquitous expression in testis (RPKM 23.4), bone marrow (RPKM 18.5) and 25 other tissues.

功能概要

启用序列特异性双链 DNA 结合活性。预计参与 RNA 聚合酶 II 的转录调控。预计活跃于核心。 [由基因组资源联盟提供,2022 年 4 月]

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZNF410 基因产物(5)

mRNA Protein Name
NM_001242924.2 NP_001229853.1 zinc finger protein 410 isoform a
NM_001242926.2 NP_001229855.1 zinc finger protein 410 isoform c
NM_001242927.2 NP_001229856.1 zinc finger protein 410 isoform d
NM_001242928.2 NP_001229857.1 zinc finger protein 410 isoform e
NM_021188.3 NP_067011.1 zinc finger protein 410 isoform b
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
33859416 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: 通过突变表型推断
33301730 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20211142 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
enables sequence-specific double-stranded DNA binding IMP
IMP: 通过突变表型推断
33301730 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
33301730 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
33859416 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
33301730 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ZNF410 蛋白结构

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (220 - 243)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (266 - 292)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (295 - 321)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (325 - 349)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 478 a.a.
蛋白主名 其他名称

zinc finger protein 410

another partner for ARF 1

ZNF410 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ZNF410 Q86VK4 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
Intra ZNF410 Q86VK4 ZNF397 Homo sapiens Q8NF99
Y2H Prey Pooling
25416956
Intra ZNF410 Q86VK4 ZNF397 Homo sapiens Q8NF99
Validated Y2H
25416956
Intra ZNF410 Q86VK4 ZNF397 Homo sapiens Q8NF99
Y2H Array
25416956
Intra ZNF410 Q86VK4 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
25416956
Intra ZNF410 Q86VK4 FSD2 Homo sapiens A1L4K1
Validated Y2H
25416956
Intra ZNF410 Q86VK4 FSD2 Homo sapiens A1L4K1
Y2H Array
25416956
Intra ZNF410 Q86VK4 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra ZNF410 Q86VK4 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
25416956
Intra ZNF410 Q86VK4 TSGA10 Homo sapiens Q9BZW7
Y2H Prey Pooling
25416956
Intra ZNF410 Q86VK4 TSGA10 Homo sapiens Q9BZW7
Validated Y2H
25416956
Intra ZNF410 Q86VK4 RAB3IP Homo sapiens Q96QF0
Validated Y2H
25416956
Intra ZNF410 Q86VK4 RAB3IP Homo sapiens Q96QF0
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spermatogenic Failure 11

SPGF11

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus ZNF410 VGNC VGNC:80788
Bos taurus ZNF410 VGNC VGNC:37271
Macaca mulatta ZNF410 VGNC VGNC:99352
Rattus norvegicus ZNF410 RGD RGD:1305636
Canis familiaris ZNF410 VGNC VGNC:48722
Mus musculus ZNF410 MGD MGI:1289280