EIF4G2 - eukaryotic translation initiation factor 4 gamma 2 Gene

中文名称：真核翻译起始因子 4 伽玛 2

种属: Homo sapiens

同用名: P97; AAG1; DAP5; NAT1

关于 EIF4G2

功能概要

翻译起始是由真核翻译起始因子 4F (eIF4F) 对帽结构的特异性识别介导的，它是一种帽结合蛋白复合物，由三个亚基组成：eIF4A、eIF4E 和 eIF4G。该基因编码的蛋白质与包含 eIF4A 和 eIF3 结合位点的 eIF4G 的 C 端区域具有相似性；此外，eIF4G 在 N 端包含一个 eIF4E 的结合位点。与支持帽依赖性和独立翻译的 eIF4G 不同，该基因产物通过形成翻译失活复合物作为翻译的一般阻遏物。体外和体内研究表明，这种 mRNA 的翻译完全从非 AUG (GUG) 密码子开始。已经描述了编码该基因的不同同种型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq, Jul 2008]