2. Gene
  3. EIF4A1 - eukaryotic translation initiation factor 4A1 Gene

EIF4A1 - eukaryotic translation initiation factor 4A1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：真核翻译起始因子 4A1

种属: Homo sapiens

同用名: DDX2A; EIF4A; EIF-4A; eIF4A-I; eIF-4A-I

基因 ID: 1973 | 基因类型: protein coding

关于 EIF4A1

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,572,825-7,579,006 (from NCBI)

This gene has 36 transcripts (splice variants), 131 orthologues and 38 paralogues. Ubiquitous expression in appendix (RPKM 182.3), bone marrow (RPKM 177.5) and 25 other tissues.

功能概要

启用双链 RNA 结合活性。预计参与细胞质翻译起始。位于细胞质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables double-stranded RNA binding activity. Predicted to be involved in cytoplasmic translational initiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

EIF4A1 基因产物(2)

mRNA Protein Name
NM_001204510.2 NP_001191439.1 eukaryotic initiation factor 4A-I isoform 2
NM_001416.4 NP_001407.1 eukaryotic initiation factor 4A-I isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables double-stranded RNA binding IDA
IDA: 通过直接分析推断
21266579 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9548260 GOA
enables translation initiation factor activity IDA
IDA: 通过直接分析推断
34731628 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cytoplasmic translational initiation IDA
IDA: 通过直接分析推断
34731628 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
20156963 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12426392 GOA
located in nuclear stress granule IDA
IDA: 通过直接分析推断
20156963 GOA
NOT located in nucleus IDA
IDA: 通过直接分析推断
12426392 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
20156963 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
20156963 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EIF4A1 蛋白结构

DEAD

DEAD: DEAD/DEAH box helicase (57 - 222)

Helicase_C

Helicase_C: Helicase conserved C-terminal domain (292 - 367)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
蛋白主名 其他名称

eukaryotic initiation factor 4A-I

ATP-dependent RNA helicase eIF4A-1

EIF4A1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
EIF4A1 P60842 EIF4G2 Homo sapiens P78344
Anti Tag CoIP
35271311
种属内
EIF4A1 P60842 EIF4G2 Homo sapiens P78344
Anti Tag CoIP
16932749
种属内
EIF4A1 P60842 EIF4G2 Homo sapiens P78344
Pull Down
16166382
种属内
EIF4A1 P60842 EIF4G2 Homo sapiens P78344
Anti Tag CoIP
33961781
种属内
EIF4A1 P60842 EIF4G1 Homo sapiens Q04637-1
DLS
18606994
种属内
EIF4A1 P60842 EIF4G1 Homo sapiens Q04637-1
GMS
18606994
种属内
EIF4A1 P60842 EIF4G1 Homo sapiens Q04637
Anti Tag CoIP
33961781
种属内
EIF4A1 P60842 EIF4G1 Homo sapiens Q04637
DLS
18606994
种属内
EIF4A1 P60842 EIF4G1 Homo sapiens Q04637
SPR
19203580
种属内
EIF4A1 P60842 EIF4G1 Homo sapiens Q04637
ITC
23478064
种属内
EIF4A1 P60842 EIF4G1 Homo sapiens Q04637
Anti Tag CoIP
23023399
种属内
EIF4A1 P60842 EIF4G1 Homo sapiens Q04637
GMS
18606994
种属内
EIF4A1 P60842 EIF4G1 Homo sapiens Q04637
Anti Tag CoIP
16932749
种属内
EIF4A1 P60842 EIF4G1 Homo sapiens Q04637
GMS
23478064
种属内
EIF4A1 P60842 EIF4G1 Homo sapiens Q04637
Pull Down
16932749
种属内
EIF4A1 P60842 PDCD4 Homo sapiens Q53EL6
NMR
18296639
种属内
EIF4A1 P60842 PDCD4 Homo sapiens Q53EL6
Anti Bait CoIP
17353931
种属内
EIF4A1 P60842 PDCD4 Homo sapiens Q53EL6
ITC
19204291
种属内
EIF4A1 P60842 PDCD4 Homo sapiens Q53EL6
X-Ray Diffraction
19204291
种属内
EIF4A1 P60842 PDCD4 Homo sapiens Q53EL6
Anti Bait CoIP
24413684
种属内
EIF4A1 P60842 PDCD4 Homo sapiens Q53EL6
SPR
18296639
种属内
EIF4A1 P60842 PDCD4 Homo sapiens Q53EL6
Anti Tag CoIP
33961781
种属内
EIF4A1 P60842 PDCD4 Homo sapiens Q53EL6
GMS
19204291
种属内
EIF4A1 P60842 PDCD4 Homo sapiens Q53EL6
Anti Tag CoIP
28514442
种属内
EIF4A1 P60842 PDCD4 Homo sapiens Q53EL6
Solution Sedimentation
19204291
种属间: 跨种属相互作用 种属内: 同种属相互作用

EIF4A1 抗体

目录号 产品名 应用 反应物种
HY-P80650 eIF4A1 Antibody (YA774) WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat

关联疾病

疾病名称 别名
Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

X-Linked Intellectual Disability And Macroorchidism

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome
Fragile X-Associated Tremor/Ataxia Syndrome

Fxtas Syndrome

Fragile X Tremor/Ataxia Syndrome

Fxtas
Spinocerebellar Ataxia 8

Spinocerebellar Ataxia Type 8

SCA8

Ataxia, Spinocerebellar, Type 8
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-19560 SBI-0640756 Inhibitor 99.75% 否
HY-RS04277 EIF4EBP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-129768 CMLD012072 Inhibitor / 否
HY-129769 CMLD012073 Inhibitor / 否
HY-145240 eIF4E-IN-1 Inhibitor / 否
HY-RS04270 EIF4A1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04280 EIF4ENIF1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04281 EIF4G1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-164524 SBI-0640726 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus EIF4A1 RGD RGD:735141
Felis catus EIF4A1 VGNC VGNC:98947
Mus musculus EIF4A1 MGD MGI:95303
Bos taurus EIF4A1 VGNC VGNC:28404
Macaca mulatta EIF4A1 VGNC VGNC:99145
Others EIF4A1 NCBI
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