SGO2 - shugoshin 2 Gene

中文名称：修护神 2

种属: Homo sapiens

同用名: SGOL2; TRIPIN

基因 ID: 151246 | 基因类型: protein coding

关于 SGO2

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:200,526,142-200,584,096 (from NCBI)

This gene has 6 transcripts (splice variants), 127 orthologues and 1 paralogue. Biased expression in testis (RPKM 14.8), lymph node (RPKM 3.1) and 10 other tissues.

功能概要

预测参与同源染色体分离；减数分裂姐妹染色单体凝聚；和有丝分裂姐妹染色单体分离。预计在减数分裂核分裂的上游或内部行动；维持减数分裂姐妹染色单体内聚力、着丝粒的正调控；和蛋白质定位。位于染色体、着丝粒区和核体。有丝分裂粘连蛋白复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to be involved in homologous chromosome segregation; meiotic sister chromatid cohesion; and mitotic sister chromatid segregation. Predicted to act upstream of or within meiotic nuclear division; positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric; and protein localization. Located in chromosome, centromeric region and nuclear body. Part of mitotic cohesin complex. [provided by Alliance of Genome Resources, Apr 2022]

SGO2 基因产物(3)

mRNA	Protein	Name
NM_001160033.1	NP_001153505.1	shugoshin 2 isoform 2
NM_001160046.1	NP_001153518.1	shugoshin 2 isoform 3
NM_152524.6	NP_689737.4	shugoshin 2 isoform 1

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16541025	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in chromosome, centromeric region	IDA IDA: 通过直接分析推断	17485487	GOA
part of mitotic cohesin complex	IDA IDA: 通过直接分析推断	18084284	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

shugoshin 2

shugoshin-like 2

SGO2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	SGO2	Q562F6	PPP1CA	Homo sapiens	P62136	Anti Bait CoIP	21666598
Intra	SGO2	Q562F6	PPP1CA	Homo sapiens	P62136	Anti Tag CoIP	21666598
Intra	SGO2	Q562F6	PPP2R5A	Homo sapiens	Q15172	Anti Tag CoIP	16541025
Intra	SGO2	Q562F6	PPP2CA	Homo sapiens	P67775	Anti Bait CoIP	16541025
Intra	SGO2	Q562F6	PPP2CA	Homo sapiens	P67775	Anti Tag CoIP	33961781
Intra	SGO2	Q562F6	MAD2L1	Homo sapiens	Q13257	Anti Bait CoIP	21666598
Intra	SGO2	Q562F6	MAD2L1	Homo sapiens	Q13257	Y2H	21666598
Intra	SGO2	Q562F6	MAD2L1	Homo sapiens	Q13257	Anti Tag CoIP	21666598
Intra	SGO2	Q562F6	MAD2L1	Homo sapiens	Q13257	ITC	21666598

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Perrault Syndrome

Gonadal Dysgenesis, Xx Type, With Deafness	Ovarian Dysgenesis With Sensorineural Deafness
Gonadal Dysgenesis, Xx Type	Gonadal Dysgenesis With Auditory Dysfunction, Autosomal Recessive Inheritance
Gonadal Dysgenesis With Sensorineural Deafness, Autosomal Recessive Inheritance	Xx Gonodal Dysgenesis-Deafness Syndrome
Xx Gonodal Dysgenesis-Hearing Loss Syndrome	Gonadal Dysgenesis Xx Type Deafness

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Chronic Atrial And Intestinal Dysrhythmia

CAID	Caid Syndrome
Cohesinopathy Affecting Heart And Gut Rhythm	Chronic Atrial Intestinal Dysrhythmia Syndrome
Chronic Atrial And Intestinal Dysrhythmia Syndrome	Chronic Atrial Dysrhythmia-Intestinal Motility Disorder
Dysrhythmia, Atrial And Intestinal, Chronic

Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy	Vanishing White Matter Disease
Ovarioleukodystrophy	Vanishing White Matter Leukodystrophy
Childhood Ataxia With Central Nervous System Hypomyelinization	Cach
Cach Syndrome	Myelinosis Centralis Diffusa
VWM	Cle
Childhood Ataxia With Central Nervous System Hypomyelination	Childhood Ataxia With Diffuse Central Nervous System Hypomyelination
Cach/Vwm	Cach/Vwm Syndrome
Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter	Cree Leukoencehalopathy
Late Infantile Cach Syndrome	Juvenile Or Adult Cach Syndrome
Congenital Or Early Infantile Cach Syndrome	Leukodystrophy With Vanishing White Matter

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12808	SGO2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	SGO2	VGNC	VGNC:34546
Mus musculus	SGO2	MGD	MGI:1098767
Macaca mulatta	SGO2	VGNC	VGNC:104555
Rattus norvegicus	SGO2	RGD	RGD:1308450
Felis catus	SGO2	VGNC	VGNC:65082
Canis familiaris	SGO2	VGNC	VGNC:46101

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SGO2 - shugoshin 2 Gene

关于 SGO2

功能概要

SGO2 基因产物(3)

SGO2 蛋白互作信息

关联疾病

直系同源

热门区域

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SGO2 - shugoshin 2 Gene

关于 SGO2

功能概要

SGO2 基因产物(3)

SGO2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z