1. Gene
  2. KIF18A - kinesin family member 18A Gene

KIF18A - kinesin family member 18A Gene

中文名称:驱动蛋白家族成员 18A

种属: Homo sapiens

同用名: PPP1R99; MS-KIF18A

基因 ID: 81930 | 基因类型: protein coding

关于 KIF18A

Cytogenetic location: 11p14.1 Genomic coordinates (GRCh38): 11:28,020,619-28,108,156 (from NCBI)

This gene has 4 transcripts (splice variants), 190 orthologues and 41 paralogues. Biased expression in testis (RPKM 7.1), bone marrow (RPKM 2.7) and 11 other tissues.

功能概要

KIF18A 是微管相关分子马达驱动蛋白超家族的成员 (参见 MIM 148760) ,它使用 ATP 水解产生力和沿微管运动 (Luboshits 和 Benayahu,2005 [PubMed 15878648]) 。[OMIM 提供,2008 年 8 月] ]

KIF18A is a member of the Kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM, Aug 2008]

KIF18A 基因产物(1)

mRNA Protein Name
NM_031217.4 NP_112494.3 kinesin-like protein KIF18A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables actin binding IPI
IPI: 通过物理相互作用推断
18680169 GOA
enables microtubule binding IDA
IDA: 通过直接分析推断
18680169 GOA
enables microtubule plus-end binding IDA
IDA: 通过直接分析推断
17346968 GOA
enables plus-end-directed microtubule motor activity IDA
IDA: 通过直接分析推断
17346968 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15231748 GOA
enables tubulin-dependent ATPase activity IDA
IDA: 通过直接分析推断
17346968 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in microtubule depolymerization IDA
IDA: 通过直接分析推断
17346968 GOA
involved in mitotic metaphase chromosome alignment IDA
IDA: 通过直接分析推断
17346968 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in caveola IDA
IDA: 通过直接分析推断
17006958 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
17006958 GOA
located in kinetochore microtubule IDA
IDA: 通过直接分析推断
17346968 GOA
located in nucleus IDA
IDA: 通过直接分析推断
17006958 GOA
located in ruffle IDA
IDA: 通过直接分析推断
17006958 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

KIF18A 蛋白结构

Kinesin

Kinesin: Kinesin motor domain (17 - 355)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 898 a.a.
蛋白主名 其他名称

kinesin-like protein KIF18A

protein phosphatase 1, regulatory subunit 99

KIF18A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra KIF18A Q8NI77 ANAPC4 Homo sapiens Q9UJX5
Anti Bait CoIP
23288039
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Asbestosis

Idiopathic Interstitial Pneumonitis - From Asbestos Exposure

Pulmonary Fibrosis - From Asbestos Exposure

Goldberg-Shprintzen Syndrome

Goldberg-Shprintzen Megacolon Syndrome

GOSHS

Megacolon-Microcephaly Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus KIF18A RGD RGD:1561740
Felis catus KIF18A VGNC VGNC:63107
Macaca mulatta KIF18A VGNC VGNC:73944
Bos taurus KIF18A VGNC VGNC:30587
Canis familiaris KIF18A VGNC VGNC:42387
Mus musculus KIF18A MGD MGI:2446977
Others KIF18A NCBI