2. Gene
  3. PPP1R2 - protein phosphatase 1 regulatory inhibitor subunit 2 Gene

PPP1R2 - protein phosphatase 1 regulatory inhibitor subunit 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白磷酸酶 1 调节抑制因子亚基 2

种属: Homo sapiens

同用名: IPP2; IPP-2; PPP1R2A

基因 ID: 5504 | 基因类型: protein coding

关于 PPP1R2

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:195,514,428-195,543,325 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 27.3), testis (RPKM 22.2) and 25 other tissues.

功能概要

蛋白磷酸酶 1 (PP1) 是主要的真核丝氨酸/苏氨酸磷酸酶之一。该基因编码的蛋白质与 PP1 的催化亚基结合，强烈抑制其活性。在整个人类基因组中发现了十个相关的假基因。已为该基因发现了几种编码不同亚型的剪接变体。[RefSeq 提供，2015 年 10 月]

Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

PPP1R2 基因产物(4)

mRNA Protein Name
NM_001291504.2 NP_001278433.1 protein phosphatase inhibitor 2 isoform 1
NM_001291505.2 NP_001278434.1 protein phosphatase inhibitor 2 isoform 3
NM_001316325.2 NP_001303254.1 protein phosphatase inhibitor 2 isoform 4
NM_006241.8 NP_006232.1 protein phosphatase inhibitor 2 isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables molecular function inhibitor activity EXP
EXP: 通过实验结果推断
18954090 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10807923 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPP1R2 蛋白结构

IPP-2

IPP-2: Protein phosphatase inhibitor 2 (IPP-2) (42 - 173)

  • 0
  • 100
  • 205 a.a.
蛋白主名 其他名称

protein phosphatase inhibitor 2

phosphoprotein phosphatase

PPP1R2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PPP1R2 P41236 LMTK2 Homo sapiens Q8IWU2
Pull Down
12393858
种属内
PPP1R2 P41236 LMTK2 Homo sapiens Q8IWU2
Protein Kinase Assay
12393858
种属内
PPP1R2 P41236 LMTK2 Homo sapiens Q8IWU2
Y2H
12393858
种属内
PPP1R2 P41236 PPP1CC Homo sapiens P36873
BN-PAGE
10807923
种属内
PPP1R2 P41236 PPP1CC Homo sapiens P36873
Anti Tag CoIP
12761178
种属内
PPP1R2 P41236 PPP1CA Homo sapiens P62136
Y2H
22321011
种属内
PPP1R2 P41236 TINF2 Homo sapiens Q9BSI4
Pull Down
21044950
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cataract 11, Multiple Types

Cataract, Posterior Polar, 4

Ctpp4

Cpp4

Cataract 11 Multiple Types

CTRCT11

Cataract 11, Syndromic, Autosomal Recessive

Cataract 11 With Microphthalmia And Neurodevelopmental Abnormalities

Posterior Polar Cataract 4

Posterior Polar Cataract, 4

Cataract Posterior Polar 4

Syndromic Cataract 11

Cataract, Type 11, Multiple Types
Pulmonary Talcosis

Pneumoconiosis Due To Talc

Talc Pneumoconiosis

Talcosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10995 PPP1R2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PPP1R2 RGD RGD:621099
Mus musculus PPP1R2 MGD MGI:1914099
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