LMTK2 - lemur tyrosine kinase 2 Gene

中文名称：狐猴酪氨酸激酶 2

种属: Homo sapiens

同用名: BREK; KPI2; LMR2; cprk; KPI-2; hBREK; AATYK2; PPP1R100

关于 LMTK2

功能概要

该基因编码的蛋白质属于蛋白激酶超家族和蛋白酪氨酸激酶家族。它包含 N 端跨膜螺旋和长的 C 端胞质尾部，具有丝氨酸/苏氨酸/酪氨酸激酶活性。这种蛋白质与其他几种蛋白质相互作用，例如 Inhibitor-2 (Inh2) 、蛋白磷酸酶-1 (PP1C) 、p35 和肌球蛋白 VI。它使其他蛋白质磷酸化，并且在与细胞周期蛋白依赖性激酶 5 (CDK5) /p35 复合物相互作用时，它本身也被磷酸化。这种蛋白质参与神经生长因子 (NGF) -TrkA 信号传导，并且在内体膜运输中也起着关键作用。小鼠研究表明这种蛋白质在精子发生中起着重要作用。[RefSeq 提供，2009 年 10 月]

The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several Other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and Myosin VI. It phosporylates Other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (CDK5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]