2. Gene
  3. PLCL2 - phospholipase C like 2 Gene

PLCL2 - phospholipase C like 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷脂酶 C 样 2

种属: Homo sapiens

同用名: PLCE2

基因 ID: 23228 | 基因类型: protein coding

关于 PLCL2

Cytogenetic location: 3p24.3 Genomic coordinates (GRCh38): 3:16,884,955-17,090,606 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 226 orthologues and 14 paralogues. Ubiquitous expression in ovary (RPKM 4.0), lymph node (RPKM 3.4) and 23 other tissues.

功能概要

启用 GABA 受体结合活性。预计参与冷诱导产热和磷脂酰肌醇介导的信号传导的负调节。预计在多个过程的上游或内部起作用，包括 B 细胞激活； γ-氨基丁酸信号通路； B 细胞受体信号通路的负调控。预计位于细胞质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables GABA Receptor binding activity. Predicted to be involved in negative regulation of cold-induced thermogenesis and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within several processes, including B cell activation; gamma-aminobutyric acid signaling pathway; and negative regulation of B cell receptor signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PLCL2 基因产物(2)

mRNA Protein Name
NM_001144382.2 NP_001137854.1 inactive phospholipase C-like protein 2 isoform 1
NM_015184.5 NP_055999.2 inactive phospholipase C-like protein 2 isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GABA receptor binding IDA
IDA: 通过直接分析推断
16754670 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15231748 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PLCL2 蛋白结构

EF-hand_like

EF-hand_like: Phosphoinositide-specific phospholipase C, efhand-like (217 - 299)

PI-PLC-X

PI-PLC-X: Phosphatidylinositol-specific phospholipase C, X domain (302 - 445)

PI-PLC-Y

PI-PLC-Y: Phosphatidylinositol-specific phospholipase C, Y domain (491 - 608)

C2

C2: C2 domain (630 - 719)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1001 a.a.
蛋白主名 其他名称

inactive phospholipase C-like protein 2

PLC-L(2)

PLCL2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PLCL2 Q9UPR0 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
种属内
PLCL2 Q9UPR0 FGFR3 Homo sapiens P22607
Y2H Array
32814053
种属内
PLCL2 Q9UPR0 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
种属内
PLCL2 Q9UPR0 HRAS Homo sapiens P01112
Y2H Array
32814053
种属内
PLCL2 Q9UPR0 HRAS Homo sapiens P01112
Y2H Pooling
32814053
种属内
PLCL2 Q9UPR0 HRAS Homo sapiens P01112
Validated Y2H
32814053
种属内
PLCL2 Q9UPR0 GSN Homo sapiens P06396
Validated Y2H
32814053
种属内
PLCL2 Q9UPR0 GSN Homo sapiens P06396
Y2H Array
32814053
种属内
PLCL2 Q9UPR0 GSN Homo sapiens P06396
Y2H Pooling
32814053
种属内
PLCL2 Q9UPR0 PPP1CA Homo sapiens P62136
Y2H
15231748
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spondylometaepiphyseal Dysplasia, Short Limb-Hand Type

Spondyloepimetaphyseal Dysplasia-Short Limb-Abnormal Calcification Syndrome

Smed-Sl

Smed-Sl/Ac

Smed Short Limb-Abnormal Calcification Type

Smed Short Limb-Hand Type

Spondylometaepiphyseal Dysplasia Short Limb-Hand Type

Smed, Type Ii

Smed Type 2

Spondylometaepiphyseal Dysplasia Short Limb-Abnormal Calcification Type

Smed, Short Limb-Hand Type

Spondylometaepiphyseal Dysplasia, Short Limb-Abnormal Calcification Type

Smed, Short Limb-Abnormal Calcification Type

Spondyloepimetaphyseal Dysplasia - Short Limb - Abnormal Calcification

Spondyloepimetaphyseal Dysplasia, Short Limb-Hand Type

SEMD-SL

Smed Type Ii

Dysplasia, Spondylometaepiphyseal, Short Limb-Hand Type
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10665 PLCL2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PLCL2 RGD RGD:1305941
Mus musculus PLCL2 MGD MGI:1352756
Felis catus PLCL2 VGNC VGNC:68899
Canis familiaris PLCL2 VGNC VGNC:44655
Bos taurus PLCL2 VGNC VGNC:32992
Macaca mulatta PLCL2 VGNC VGNC:76168
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z